Reference : Three-dimensional structural view of the central metabolic network of Thermotoga maritima.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/13050
Three-dimensional structural view of the central metabolic network of Thermotoga maritima.
English
Zhang, Ying [> >]
Thiele, Ines mailto []
Weekes, Dana [> >]
Li, Zhanwen [> >]
Jaroszewski, Lukasz [> >]
Ginalski, Krzysztof [> >]
Deacon, Ashley M. [> >]
Wooley, John [> >]
Lesley, Scott A. [> >]
Wilson, Ian A. [> >]
Palsson, Bernhard [> >]
Osterman, Andrei [> >]
Godzik, Adam [> >]
2009
Science (New York, N.Y.)
325
5947
1544-1549
Yes (verified by ORBilu)
0036-8075
1095-9203
United States
[en] Bacterial Proteins/chemistry/metabolism ; Computational Biology ; Computer Simulation ; Enzymes/chemistry/metabolism ; Evolution, Molecular ; Genes, Bacterial ; Genome, Bacterial ; Metabolic Networks and Pathways ; Models, Biological ; Models, Molecular ; Protein Conformation ; Protein Folding ; Protein Structure, Tertiary ; Systems Biology ; Thermotoga maritima/chemistry/genetics/metabolism
[en] Metabolic pathways have traditionally been described in terms of biochemical reactions and metabolites. With the use of structural genomics and systems biology, we generated a three-dimensional reconstruction of the central metabolic network of the bacterium Thermotoga maritima. The network encompassed 478 proteins, of which 120 were determined by experiment and 358 were modeled. Structural analysis revealed that proteins forming the network are dominated by a small number (only 182) of basic shapes (folds) performing diverse but mostly related functions. Most of these folds are already present in the essential core (approximately 30%) of the network, and its expansion by nonessential proteins is achieved with relatively few additional folds. Thus, integration of structural data with networks analysis generates insight into the function, mechanism, and evolution of biological networks.
http://hdl.handle.net/10993/13050
10.1126/science.1174671

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