Reference : A systems biology approach to studying the role of microbes in human health.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/13033
A systems biology approach to studying the role of microbes in human health.
English
Thiele, Ines mailto [> >]
Heinken, Almut Katrin mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Fleming, Ronan MT mailto [> >]
2013
Current Opinion in Biotechnology
24
1
4-12
Yes (verified by ORBilu)
0958-1669
England
[en] Biofilms ; Computer Simulation ; Health ; Host-Pathogen Interactions ; Humans ; Intestines/microbiology ; Metabolic Networks and Pathways ; Microbial Interactions ; Models, Biological ; Systems Biology/methods
[en] Host-microbe interactions play a crucial role in human health and disease. Of the various systems biology approaches, reconstruction of genome-scale metabolic networks combined with constraint-based modeling has been particularly successful at in silico predicting the phenotypic characteristics of single organisms. Here, we summarize recent studies, which have applied this approach to investigate microbe-microbe and host-microbe metabolic interactions. This approach can be also expanded to investigate the properties of an entire microbial community, as well as single organisms within the community. We illustrate that the constraint-based modeling approach is suitable to model host-microbe interactions at molecular resolution and will enable systematic investigation of metabolic links between the human host and its microbes. Such host-microbe models, combined with experimental data, will ultimately further our understanding of how microbes influence human health.
http://hdl.handle.net/10993/13033
10.1016/j.copbio.2012.10.001
Copyright (c) 2012 Elsevier Ltd. All rights reserved.

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