Reference : Fine genetic mapping of the proximal part of mouse chromosome 2 excludes Pax-8 as a c...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/1274
Fine genetic mapping of the proximal part of mouse chromosome 2 excludes Pax-8 as a candidate gene for Danforth's short tail (Sd).
English
Koseki, H. [> >]
Zachgo, J. [> >]
Mizutani, Y. [> >]
Simon-Chazottes, D. [> >]
Guenet, J. L. [> >]
Balling, Rudi mailto []
Gossler, A. [> >]
1993
Mammalian Genome : Official Journal of the International Mammalian Genome Society
4
6
324-7
Yes (verified by ORBilu)
0938-8990
1432-1777
UNITED STATES
[en] Animals ; Chromosome Mapping ; Crosses, Genetic ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Spinal Cord/abnormalities ; Tail ; Urogenital Abnormalities
[en] Danforth's short tail (Sd) is a semidominant mutation of the mouse with effects on the skeleton and the urogenital system. In view of its phenotype and its position in the proximal part of Chromosome (Chr) 2, three genes qualified as possible candidates: Pax-8, a paired box-containing gene; Midkine (Mdk), a retinoic acid-responsive gene; and a new locus (Etl-4) identified by enhancer trapping with a lacZ reporter gene which showed expression in the notochord, the mesonephric mesenchyme, and the apical ectodermal ridge. Three different backcrosses involving all three genes in different combinations were set up and analyzed. From our results we conclude that Sd, Etl-4, Pax-8, and Mdk are independent loci, with Etl-4 being the closest genetic marker (1.1 +/- 1.4 cM) to the Danforth's short tail (Sd) gene.
http://hdl.handle.net/10993/1274

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