Reference : Pax1, a member of the paired box-containing class of developmental control genes, is ...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/1271
Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH).
English
Schnittger, S. [> >]
Rao, V. V. [> >]
Deutsch, U. [> >]
Gruss, P. [> >]
Balling, Rudi mailto []
Hansmann, I. [> >]
1992
Genomics
14
3
740-4
Yes (verified by ORBilu)
0888-7543
1089-8646
UNITED STATES
[en] Animals ; Chromosome Mapping ; Chromosomes, Human, Pair 20 ; Cricetinae ; DNA-Binding Proteins/genetics ; Genes, Homeobox ; Humans ; Hybrid Cells ; In Situ Hybridization ; In Situ Hybridization, Fluorescence ; Paired Box Transcription Factors ; Transcription Factors/genetics
[en] Pax-1, a member of a murine multigene family, belongs to the paired box-containing class of developmental control genes first identified in Drosophila. The Pax-1 gene encodes a sequence-specific DNA-binding protein with transcriptional activating properties and has been found to be mutated in the autosomal recessive mutation undulated (un) on mouse chromosome 2 with vertebral anomalies along the entire rostrocaudal axis. By radioactive in situ hybridization (ISH) using a fragment from the murine Pax-1 paired box that is almost identical to the respective sequences from the cognate human gene HuP48 and fluorescence in situ hybridization (FISH) using a complete mouse Pax-1 cDNA, we have assigned the human homologue of murine Pax-1, the PAX1 locus, to chromosome 20p. The map position of PAX1 after FISH (FL-pter value of 0.34 +/- 0.04) corresponds to band p11.2. These results confirm the exceptional homology between human chromosome 20 and the distal segment of mouse chromosome 2, extending from bands F to G, and add PAX1 to the group of genes on 20p like PTPA, PRNP, SCG1, BMP2A, which are located in proximity on both chromosomes.
http://hdl.handle.net/10993/1271

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.