Reference : Assessment of the safety of foods derived from genetically modified crops
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/12405
Assessment of the safety of foods derived from genetically modified crops
English
König, Ariane mailto [Harvard University, Boston, USA > Harvard School of Public Health > Harvard Center for Risk Analysis]
Cockburn, A. [> >]
Crevel, R. [> >]
Debruyne, E. [> >]
Grafstroem, R. [> >]
Hammerling, U. [> >]
Kimber, I. [> >]
Knudsen, I. [> >]
Kuiper, H. A. [> >]
Peijnenburg, A. A. C. M. [> >]
Penninks, A. [> >]
Poulsen, M. [> >]
Schauzu, M. [> >]
Wal, J. M. [> >]
4-Feb-2004
Food & Chemical Toxicology
Elsevier Science
42
1047-1088
Yes (verified by ORBilu)
International
0278-6915
Exeter
United Kingdom
[en] Food ; Plant biotechnology ; Genetic modification ; Genetic engineering ; Genetic manipulation ; Transgenic crops ; Novel foods ; Recombinant proteins ; Plant metabolism ; Regulation ; Safetyassessment ; Risk analysis ; Molecular characterisation ; Toxicology ; Allergy ; Substantial equivalence ; Unintended effects ; Bioinformatics ; In vitro test methods ; In vivo test methods ; Animal testing ; Post market monitoring ; Estimated consumption ; Exposure assessment ; Compositional analysis ; Advanced analytical methods ; Profiling
[en] This paper provides guidance on how to assess the safety of foods derived from genetically modified crops (GM crops); it summarises conclusions and recommendations of Working Group 1 of the ENTRANSFOOD project. The paper provides an approach for adapting the test strategy to the characteristics of the modified crop and the introduced trait, and assessing potential unintended effects from the genetic modification. The proposed approach to safetyassessment starts with the comparison of the new GM crop with a traditional counterpart that is generally accepted as safe based on a history of human food use (the concept of substantial equivalence). This case-focused approach ensures that foods derived from GM crops that have passed this extensive test-regime are as safe and nutritious as currently consumed plant-derived foods. The approach is suitable for current and future GM crops with more complex modifications. First, the paper reviews test methods developed for the risk assessment of chemicals, including food additives and pesticides, discussing which of these methods are suitable for the assessment of recombinant proteins and whole foods. Second, the paper presents a systematic approach to combine test methods for the safetyassessment of foods derived from a specific GM crop. Third, the paper provides an overview on developments in this area that may prove of use in the safetyassessment of GM crops, and recommendations for research priorities. It is concluded that the combination of existing test methods provides a sound test-regime to assess the safety of GM crops. Advances in our understanding of molecular biology, biochemistry, and nutrition may in future allow further improvement of test methods that will over time render the safetyassessment of foods even more effective and informative.
http://hdl.handle.net/10993/12405
Science Direct ranked the article #9 of the Top 25 articles published in the same quarterly in the area of pharmacology, toxicology and pharmaceutical sciences

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