Reference : Diseases as network perturbations
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/1238
Diseases as network perturbations
English
del Sol Mesa, Antonio mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Balling, Rudi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Hood, Leroy [Institute for Systems Biology (ISB), Seattle, USA]
Galas, David J. [Institute for Systems Biology (ISB), Seattle, USA]
2010
Current Opinion in Biotechnology
Elsevier Ltd
21
4
566-571
Yes (verified by ORBilu)
0958-1669
[en] networks ; perturbations ; cellular networks ; disease network analysis
[en] The tremendous amount of the data obtained from the study of complex biological systems changes our view on the pathogenesis of human diseases. Instead of looking at individual components of biological processes, we focus our attention more on the interaction and dynamics of biological systems. A network representation and analysis of the physiology and pathophysiology of biological systems is an effective way to study their complex behavior. Specific perturbations can trigger cascades of failures, which lead to the malfunctioning of cellular networks and as a result to the development of specific diseases. In this review we discuss recent developments in the field of disease network analysis and highlight some of the topics and views that we think are important for understanding network-based disease mechanisms.
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
http://hdl.handle.net/10993/1238
10.1016/j.copbio.2010.07.010

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