Reference : EuroPhenome: a repository for high-throughput mouse phenotyping data
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/1235
EuroPhenome: a repository for high-throughput mouse phenotyping data
English
Morgan, Hugh [MRC Harwell, Mammalian Genetics Unit]
Beck, Tim [MRC Harwell, Mammalian Genetics Unit]
Blake, Andrew [MRC Harwell, Mammalian Genetics Unit]
Gates, Hilary [MRC Harwell, Mammalian Genetics Unit]
Adams, Niels [MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK]
Debouzy, Guillaume [Institut Clinique de la Souris (ICS), 1 Rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France,]
Leblanc, Sophie [Institut Clinique de la Souris (ICS), 1 Rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France,]
Lengger, Christoph [Helmholtz Zentrum Munich German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany,]
Maier, Holger [Helmholtz Zentrum Munich German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany,]
Melvin, David [The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK]
Meziane, Hamid [Institut Clinique de la Souris (ICS), 1 Rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France,]
Richardson, Dave [The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK]
Wells, Sara [MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK]
White, Jacqui [The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK]
Wood, Joe [MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK]
Eumodic, Consortium [The members of the EUMODIC Consortium are listed in the Appendix 1]
Hrabé de Angelis, Martin [Helmholtz Zentrum Munich German Research Center for Environmental Health, Institute of Experimental Genetics and German Mouse Clinic, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany,]
Hrabé de Angelis, Martin [Technische Universität München, Center of Life and Food Sciences Weihenstephan, Alte Akademie 8, 85354]
Brown, Steve D. M. [MRC Harwell, Mammalian Genetics Unit]
Hancock, John M. [MRC Harwell, Mammalian Genetics Unit]
Mallon, Ann-Marie [MRC Harwell, Mammalian Genetics Unit]
Balling, Rudi mailto [> >]
2010
Nucleic Acids Research
Oxford University Press
38
1
577-585
Yes (verified by ORBilu)
0305-1048
1362-4962
[en] EUMODIC ; phenotype ; mouse ; EMPReSSslim ; EUCOMM ; EuroPhenome ; mutant ; data mining ; biological ontologies
[en] The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated highthroughput phenotyping data arising from projects such as EUMODIC. EUMODIC is gathering data from the EMPReSSslim pipeline (http://www.empress .har.mrc.ac.uk/) which is performed on inbred mouse strains and knock-out lines arising from the EUCOMM project. The EuroPhenome interface allows the user to access the data via the phenotype or genotype. It also allows the user to access the data in a variety of ways, including graphical display, statistical analysis and access to the raw data via web services. The raw phenotyping data captured in EuroPhenome is annotated by an annotation pipeline which automatically identifies statistically different mutants from the appropriate baseline and assigns ontology terms for that specific test. Mutant phenotypes can be quickly identified using two EuroPhenome tools: PhenoMap, a graphical representation of statistically relevant phenotypes, and mining for a mutant using ontology terms. To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies.
http://hdl.handle.net/10993/1235
10.1093/nar/gkp1007
http://www.EuroPhenome.org
http://www.empress .har.mrc.ac.uk/

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