Reference : Light microscopy applications in systems biology: opportunities and challenges.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/1135
Light microscopy applications in systems biology: opportunities and challenges.
English
Antony, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Trefois, Christophe mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Stojanovic, Aleksandar mailto [University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT) > >]
Baumuratov, Aidos mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kozak, Karol mailto [ETH Zurich > Institute for Biochemistry > Light Microscopy Centre (LMSC)]
11-Apr-2013
Cell Communication and Signaling
BioMed Central
11
1
Systems Biology and Medicine
1-19
Yes
International
1478-811X
[en] Microscopy ; Systems biology ; Image analysis ; Segmentation ; Features ; Machine learning
[en] Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biological scales in living cells. The combination of molecular biology and imaging provides a bottom-up tool for direct insight into how molecular processes work on a cellular scale. However, imaging can also be used as a top-down approach to study the behavior of a system without detailed prior knowledge about its underlying molecular mechanisms. In this review, we highlight the recent developments on microscopy-based systems analyses and discuss the complementary opportunities and different challenges with high-content screening and high-throughput imaging. Furthermore, we provide a comprehensive overview of the available platforms that can be used for image analysis, which enable community-driven efforts in the development of image-based systems biology.
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
University of Luxembourg - UL
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/10993/1135
10.1186/1478-811X-11-24
http://www.biosignaling.com/content/11/1/24
© 2013 Antony et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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