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See detailEngineered Communities: Industry-Related Open-Air Schools Forging Common Identities and Forms of Citizenship? (c. 1913-1963)
Thyssen, Geert UL

in History of Education & children's Literature (in press)

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See detailCompetition Numbers, Quasi-Line Graphs and Holes
McKay, Brendan; Schweitzer, Pascal; Schweitzer, Patrick UL

in SIAM Journal on Discrete Mathematics (in press)

The competition graph of an acyclic directed graph D is the undirected graph on the same vertex set as D in which two distinct vertices are adjacent if they have a common out-neighbor in D. The ... [more ▼]

The competition graph of an acyclic directed graph D is the undirected graph on the same vertex set as D in which two distinct vertices are adjacent if they have a common out-neighbor in D. The competition number of an undirected graph G is the least number of isolated vertices that have to be added to G to make it the competition graph of an acyclic directed graph. We resolve two conjectures concerning competition graphs. First we prove a conjecture of Opsut by showing that the competition number of every quasi-line graph is at most 2. Recall that a quasi-line graph, also called a locally co-bipartite graph, is a graph for which the neighborhood of every vertex can be partitioned into at most two cliques. To prove this conjecture we devise an alternative characterization of quasi-line graphs to the one by Chudnovsky and Seymour. Second, we prove a conjecture of Kim by showing that the competition number of any graph is at most one greater than the number of holes in the graph. Our methods also allow us to prove a strengthened form of this conjecture recently proposed by Kim, Lee, Park and Sano, showing that the competition number of any graph is at most one greater than the dimension of the subspace of the cycle space spanned by the holes. [less ▲]

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See detailTranslanguaging practices on iTEO in Preschools
Kirsch, Claudine UL

in Translation and Translanguaging in Multilingual Contexts (in press), 3(2),

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See detailA Stein deficit for the logarithmic Sobolev inequality
Ledoux, Michel; Nourdin, Ivan UL; Peccati, Giovanni UL

in Science China Mathematics (in press)

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See detailSelf-reported dependence on mobile phones in young adults: A European cross-cultural empirical survey.
Lopez-Fernandez, Olatz; Kuss, Daria J.; Romo, Lucia et al

in Journal of behavioral addictions (in press)

Background and aims Despite many positive benefits, mobile phone use can be associated with harmful and detrimental behaviors. The aim of this study was twofold: to examine (a) cross-cultural patterns of ... [more ▼]

Background and aims Despite many positive benefits, mobile phone use can be associated with harmful and detrimental behaviors. The aim of this study was twofold: to examine (a) cross-cultural patterns of perceived dependence on mobile phones in ten European countries, first, grouped in four different regions (North: Finland and UK; South: Spain and Italy; East: Hungary and Poland; West: France, Belgium, Germany, and Switzerland), and second by country, and (b) how socio-demographics, geographic differences, mobile phone usage patterns, and associated activities predicted this perceived dependence. Methods A sample of 2,775 young adults (aged 18-29 years) were recruited in different European Universities who participated in an online survey. Measures included socio-demographic variables, patterns of mobile phone use, and the dependence subscale of a short version of the Problematic Mobile Phone Use Questionnaire (PMPUQ; Billieux, Van der Linden, & Rochat, 2008). Results The young adults from the Northern and Southern regions reported the heaviest use of mobile phones, whereas perceived dependence was less prevalent in the Eastern region. However, the proportion of highly dependent mobile phone users was more elevated in Belgium, UK, and France. Regression analysis identified several risk factors for increased scores on the PMPUQ dependence subscale, namely using mobile phones daily, being female, engaging in social networking, playing video games, shopping and viewing TV shows through the Internet, chatting and messaging, and using mobile phones for downloading-related activities. Discussion and conclusions Self-reported dependence on mobile phone use is influenced by frequency and specific application usage. [less ▲]

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See detailCharacterization of n-associative, monotone, idempotent functions on an interval which have neutral elements
Kiss, Gergely UL; Somlai, Gabor

in Semigroup Forum (in press)

We investigate monotone idempotent n-ary semigroups. One of the main results of this article is the generalization of Czogala-Drewniak Theorem, which describes the idempotent monotone associative ... [more ▼]

We investigate monotone idempotent n-ary semigroups. One of the main results of this article is the generalization of Czogala-Drewniak Theorem, which describes the idempotent monotone associative functions having neutral elements. Furthermore we present the full characterization of idempotent, monotone, n-associative functions on an interval which have neutral elements. Our description provides that monotone, idempotent, n-ary semigroups are quasitrivial. [less ▲]

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See detailOn the comprehensibility and perceived privacy protection of indirect questioning techniques
Hoffmann, Adrian; Waubert de Puiseau, Berenike; Schmidt, Alexander F. UL et al

in Behavior Research Methods (in press)

On surveys that assess sensitive personal attributes, indirect questioning aims at increasing respondents’ willingness to answer truthfully by protecting confidentiality. However, the assumption that ... [more ▼]

On surveys that assess sensitive personal attributes, indirect questioning aims at increasing respondents’ willingness to answer truthfully by protecting confidentiality. However, the assumption that subjects understand questioning procedures fully and trust them to protect their privacy is tested rarely. In a scenario-based design, we compared four indirect questioning procedures in terms of comprehensibility and perceived privacy protection. All indirect questioning techniques were found less comprehensible for respondents than a conventional direct question used for comparison. Less-educated respondents experienced more difficulties when confronted with any indirect questioning technique. Regardless of education, the Crosswise Model was found most comprehensible among the four indirect methods. Indirect questioning was perceived to increase privacy protection in comparison to a direct question. Unexpectedly, comprehension and perceived privacy protection did not correlate. We recommend assessing these factors separately in future evaluations of indirect questioning. [less ▲]

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See detailNew Kolmogorov bounds for functionals of binomial point processes
Peccati, Giovanni UL; Lachièze-Rey, Raphael

in Annals of Applied Probability (in press)

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See detailThe Family in us: Family history, family identity and self-reproductive adaptive behavior
Ferring, Dieter UL

in Integrative Psychological and Behavioral Science (in press)

This contribution is an essay about the notion of family identity reflecting shared significant experiences within a family system originating a set of signs used in social communication within and ... [more ▼]

This contribution is an essay about the notion of family identity reflecting shared significant experiences within a family system originating a set of signs used in social communication within and between families. Significant experiences are considered as experiences of events that have an immediate impact on the adaptation of the family in a given socio-ecological and cultural context at a given historical time. It is assumed that family history is stored in a shared “family memory” holding both implicit and explicit knowledge and exerting an influence on the behavior of each family member. This is described as transgenerational family memory being constituted of a system of meaningful signs. The crucial dimension underlying the logic of this essay are the ideas of adaptation as well as self-reproduction of systems. [less ▲]

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See detailDiffusion Semigroup on Manifolds with Time-Dependent Metrics
Cheng, Li Juan UL

in Forum Mathematicum (in press)

Let $L_t:=\Delta_t +Z_t $, $t\in [0,T_c)$ on a differential manifold equipped with a complete geometric flow $(g_t)_{t\in [0,T_c)}$, where $\Delta_t$ is the Laplacian operator induced by the metric $g_t ... [more ▼]

Let $L_t:=\Delta_t +Z_t $, $t\in [0,T_c)$ on a differential manifold equipped with a complete geometric flow $(g_t)_{t\in [0,T_c)}$, where $\Delta_t$ is the Laplacian operator induced by the metric $g_t$ and $(Z_t)_{t\in [0,T_c)}$ is a family of $C^{1,\infty}$-vector fields. In this article, we present a number of equivalent inequalities for the lower bound curvature condition, which include gradient inequalities, transportation-cost inequalities, Harnack inequalities and other functional inequalities for the semigroup associated with diffusion processes generated by $L_t$. To this end, we establish the derivative formula for the associated semigroup and construct couplings for these diffusion processes by parallel displacement and reflection. [less ▲]

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See detailA multifactorial and integrative approach to impulsivity in neuropsychology: Insights from the UPPS model of impulsivity
Rochat, Lucien; Billieux, Joël UL; Gagnon, Jean et al

in Journal of Clinical and Experimental Neuropsychology (in press)

Risky and excessive behaviors, such as aggressive and compulsive behaviors, are frequently described in patients with brain damage and have dramatic psychosocial consequences. Although there is strong ... [more ▼]

Risky and excessive behaviors, such as aggressive and compulsive behaviors, are frequently described in patients with brain damage and have dramatic psychosocial consequences. Although there is strong evidence that impulsivity constitutes a key factor at play in these behaviors, the literature about impulsivity in neuropsychology is to date scarce. In addition, examining and understanding these problematic behaviors requires the assumption that impulsivity is a multidimensional construct. Consequently, this article aims at shedding light on frequent risky and excessive behaviors in patients with brain damage by focusing on a unified, comprehensive, and well-validated model, namely, the UPPS model of impulsivity (Whiteside & Lynam, 2001). This model considers impulsivity as a multidimensional construct that includes four facets: urgency, (lack of) premeditation, (lack of) perseverance, and sensation seeking. Furthermore, we discuss the psychological mechanisms underlying the dimensions of impulsivity, as well as the laboratory tasks designed to assess each mechanism and their neural bases. We then present a scale specifically designed to assess these four dimensions of impulsivity in patients with brain damage and examine the data regarding this multidimensional approach to impulsivity in neuropsychology. This review supports the need to adopt a multifactorial and integrative approach toward impulsive behaviors, and the model presented provides a valuable rationale to disentangle the nature of brain systems and mechanisms underlying impulsive behaviors in patients with brain damage. It may also foster further relevant research in the field of impulsivity and improve assessment and rehabilitation of impulsive behaviors in clinical settings. [less ▲]

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See detailThe representativeness of lecture listening coursebooks: language, lectures, research-informedness
Deroey, Katrien UL

in Journal of English for Academic Purposes (in press)

This paper examines 25 lecture listening coursebooks for their representativeness of ‘real’ lectures with a view to helping EAP practitioners make informed decisions about materials selection and ... [more ▼]

This paper examines 25 lecture listening coursebooks for their representativeness of ‘real’ lectures with a view to helping EAP practitioners make informed decisions about materials selection and development. The aspects of representativeness examined are language, lecture authenticity and research-informedness. For the analysis of language, signposts of important points in the coursebooks are compared with those retrieved from a corpus of 160 authentic lectures. The EAP lectures are analysed in terms of their source, delivery and length. The materials are also reviewed for their use of findings from research into listening comprehension and lecture discourse. Results suggest that current lecture listening materials often do not reflect the language and lectures students are likely encounter on their degree programmes. Moreover, materials are typically not (systematically) informed by listening and lecture discourse research. These findings highlight the need for EAP practitioners to approach published materials critically and supplement or modify them in ways that would better serve students. The paper concludes with recommendations on how this could be done. [less ▲]

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See detailRegional Parliaments Questioning EU Affairs
Högenauer, Anna-Lena UL

in Journal of Legislative Studies (in press)

Since the Treaty of Lisbon, the desire of parliaments to adapt to their new powers has led to a new wave of Europeanization (Hefftler et al. 2015). However, the Early Warning System (EWS) and the ... [more ▼]

Since the Treaty of Lisbon, the desire of parliaments to adapt to their new powers has led to a new wave of Europeanization (Hefftler et al. 2015). However, the Early Warning System (EWS) and the Political Dialogue with the Commission only constitute one small part of parliamentary scrutiny for regional parliaments, which still largely rely on traditional tools such as mandates, debates and questions. Therefore, this paper studies a traditional mechanism of scrutiny, parliamentary questions, in order to understand the degree of Europeanization of regional parliaments and their interest in different parliamentary functions more fully. The study shows that the Europeanization of traditional scrutiny mechanisms is progressing slowly, but also that the proportion of MPs who ask EU-related questions is now relatively high. The vast majority of these MPs are not members of the European Affairs Committee. The main functions of parliamentary questions are a representative function and information function. Finally, the focus and content of parliamentary questions show that regional parliaments do indeed have a distinctive territorial approach to EU affairs. [less ▲]

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See detailGUT MICROBIOTA FUNCTIONS - METABOLISM OF NUTRIENTS AND OTHER FOOD COMPONENTS
Rowland, I; Gibson, G; Heinken, Almut Katrin UL et al

in European Journal of Nutrition (in press)

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See detailReflecting Diffusion Semigroup on Manifolds carrying Geometric Flow
Cheng, Li Juan UL; Zhang, Kun

in Journal of Theoretical Probability (in press)

Let $L_t:=\Delta_t+Z_t$ for a $C^{1,1}$-vector field $Z$ on a differentiable manifold $M$ with boundary $\partial M$, where $\Delta_t$ is the Laplacian operator, induced by a time dependent metric $g_t ... [more ▼]

Let $L_t:=\Delta_t+Z_t$ for a $C^{1,1}$-vector field $Z$ on a differentiable manifold $M$ with boundary $\partial M$, where $\Delta_t$ is the Laplacian operator, induced by a time dependent metric $g_t$ differentiable in $t\in [0,T_c)$. We first establish the derivative formula for the associated reflecting diffusion semigroup generated by $L_t$; then construct the couplings for the reflecting $L_t$-diffusion processes by parallel displacement and reflection, which are applied to gradient estimates and Harnack inequalities of the associated heat semigroup; and finally, by using the derivative formula, we present a number of equivalent inequalities for a new curvature lower bound and the convexity of the boundary, including the gradient estimates, Harnack inequalities, transportation-cost inequalities and other functional inequalities for diffusion semigroups. [less ▲]

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See detailFamily income and material deprivation: do they matter for sleep quality and quantity in early life? Evidence from a longitudinal study.
Barazzetta, Marta UL; Ghislandi, Simone

in Sleep (in press)

Study Objectives: The aim of the present paper is to investigate the determinants of sleeping patterns in children up to age 9 on a large and geographically homogeneous sample of British children and ... [more ▼]

Study Objectives: The aim of the present paper is to investigate the determinants of sleeping patterns in children up to age 9 on a large and geographically homogeneous sample of British children and parents, focusing in particular on the role of economic and social factors, specifically on income. Methods: The data of this study come from the Avon Longitudinal Study of Parents and Children, a long-term health research project that recruited over 14,000 pregnant women who were due to give birth between April 1991 and December 1992 in Bristol and its surrounding areas, including some of Somerset and Gloucestershire. Logistic regression models for the sleep problems dummies and log-linear models for the sleep quantity. Results: One additional item in the material deprivation index is associated to an increase of around 10% to 20% in the odds of having at least one sleep problem. Similarly, children from the richest families are less likely to have any sleep problem up to 115 months (around 20% reduction in the odds). Mother’s characteristics (i.e. education and mental health in the pregnancy period) are also significant predictors. Sleep quantity does not vary much and is not sensitive to socioeconomic factors. Conclusion: Exposure to income-related inequalities affects child sleep. Further research is needed in order to understand if sleep in early life influence future health and economic trajectories. [less ▲]

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See detailSchizotypal personality traits and problematic use of massively-multiplayer online role-playing games (MMORPGs)
Schimmenti, Adriano; Infanti, Alexandre; Badoud, Déborah et al

in Computers in Human Behavior (in press)

A link between maladaptive personality traits and an excessive use of massively multiplayer online role-playing games (MMORPGs) has been documented. However, the role of schizotypal personality traits in ... [more ▼]

A link between maladaptive personality traits and an excessive use of massively multiplayer online role-playing games (MMORPGs) has been documented. However, the role of schizotypal personality traits in MMORPG use is understudied. The aim of this study was to explore the potential links between schizotypal traits, motivations for playing MMORPGs, and symptoms of problematic MMORPG use. Eighty-three MMORPG gamers were enrolled in the study. They filled out questionnaires measuring schizotypal personality traits and an adapted version of the same scale designed to measure in-game schizotypal traits. All participants also filled out questionnaires assessing motivations for gaming and disordered use of MMORPGs. Results of the study showed that the disorganized and interpersonal traits of schizotypy decreased when participants were thinking about themselves in the virtual world. Schizotypal traits, together with achievement and immersion motives, predicted problematic use of MMORPGs. The findings of this study may suggest that schizotypal traits and motivations for playing can interact and play a relevant role in the onset and maintenance of problematic gaming [less ▲]

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See detailStartups' innovation behavior: An investigation into the role of entrepreneurial motivations
Gundolf, Katherine; Gast, Johanna; Geraudel, Mickaël UL

in International Journal of Innovation Management (in press)

Although it is argued that competitiveness and successful performance in the long-term is facilitated if ventures engage in innovations in diverse domains (e.g. product, process, production ... [more ▼]

Although it is argued that competitiveness and successful performance in the long-term is facilitated if ventures engage in innovations in diverse domains (e.g. product, process, production, administration, etc.), the development of diversified innovation has been rarely analyzed. As the entrepreneurs’ initial motivations to startup are likely to influence their subsequent entrepreneurial behavior, this study aims to explore whether and how entrepreneurial motivations affect diversified innovation behavior in startups. Using data on over 48.000 French startups, we present novel insights into the consequences of entrepreneurial motivation for innovation behavior. In fact, we find that distinct startup motivations can have different effects on the development of diverse innovations. As such, our findings contribute to extant research on innovation development of startups and advance the present understanding of the determinants of startups’ innovative behavior [less ▲]

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See detailDevelopment of a Cued Pro- and Antisaccade Paradigm: An Indirect Measure to Explore Automatic Components of Sexual Interest
Oberlader, Verena A.; Ettinger, Ulrich; Banse, Rainer et al

in Archives of Sexual Behavior (in press)

We developed a cued pro- and antisaccade paradigm (CPAP) to explore automatic components of sexual interest. Heterosexual participants (n = 32 women, n = 25 men) had to perform fast eye movements towards ... [more ▼]

We developed a cued pro- and antisaccade paradigm (CPAP) to explore automatic components of sexual interest. Heterosexual participants (n = 32 women, n = 25 men) had to perform fast eye movements towards and away from sexually relevant or irrelevant stimuli across a congruent (i.e. prosaccade towards sexually relevant stimuli, antisaccade away from sexually irrelevant stimuli) and an incongruent condition (i.e. prosaccade towards sexually irrelevant stimuli, antisaccade away from sexually relevant stimuli). We hypothesized that pro- and antisaccade performance would be influenced by the sexual interest-specific relevance of the presented stimulus (i.e., nude female or male stimulus) and the instructed task (i.e., pro- or antisaccade) and, thus, differ meaningfully between conditions. Results for prosaccades towards sexually relevant stimuli in the congruent condition showed that error rates were lower and latencies were shorter compared with prosaccades towards sexually irrelevant stimuli in the incongruent condition, but only for male participants. In addition, error rates for antisaccades away from sexually irrelevant stimuli in the congruent condition were lower than for antisaccades away from sexually relevant stimuli in the incongruent condition, for both female and male participants. Latencies of antisaccades, however, did not differ between conditions. In comparison with established indirect sexual interest paradigms, the CPAP benefits from measuring highly automated processes less prone to deliberate control. To this end, the CPAP could be applied to explore the interplay of early automatic and deliberate components of sexual information processing. [less ▲]

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See detailLangues de France et Charte européenne des langues régionales ou minoritaires: inventaire critique des arguments anti-ratification
Roger, Geoffrey; De Bres, Julia UL

in Sociolinguistic Studies = Estudios de Sociolingüística (in press)

Les délibérations autour de la ratification par la France de la Charte européenne des langues régionales ou minoritaires (janvier 2014 – octobre 2015) ont donné lieu à un débat national sans précédent ... [more ▼]

Les délibérations autour de la ratification par la France de la Charte européenne des langues régionales ou minoritaires (janvier 2014 – octobre 2015) ont donné lieu à un débat national sans précédent depuis 1999, donnant un éclairage nouveau sur l’opposition à une promotion de ces langues dans l’espace public. Bien qu’un récent sondage ait affirmé que ‘les freins idéologiques sur cette question ont aujourd’hui quasiment disparu’, c’est finalement le virulent argumentaire anti-ratification qui l’a emporté au Sénat. En nous appuyant sur les commentaires publiés dans les media par différents opposants à la ratification de la Charte, nous passons ici en revue les différentes stratégies idéologiques employées pour préserver le statu quo linguistique en France et y maintenir la suprématie du français. [less ▲]

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See detailHow some bankers made a million by trading just two securities?
Rinne, Kalle UL; Suominen, Matti UL

in Journal of Empirical Finance (in press)

We study a pair trading strategy that utilizes short-term return reversals in the stock market. Using U.S. data, we show that returns to our pair trading strategy exceed reasonable estimates for ... [more ▼]

We study a pair trading strategy that utilizes short-term return reversals in the stock market. Using U.S. data, we show that returns to our pair trading strategy exceed reasonable estimates for transaction costs. The strategy also generates positive alpha when controlling for the standard risk factors. Second, using transaction level data from Finland, focusing on a popular pair, we provide evidence that these kinds of pair trading returns are compensation from providing liquidity. On the days when the expected returns to our pair trading strategy are the highest, the trading volume is abnormally high and, judging from active brokers’ net trades, nearly 45% of all brokers (or their customers) engage in pair trading in accordance with our trading strategy. These brokers are mainly counterparties to few brokers that trade large quantities of stocks inconsistent with our strategy. [less ▲]

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See detailAttentional Impairments in Huntington’s Disease: A Specific Deficit for the Executive Conflict
Maurage, Pierre; Heeren, Alexandre; Lahaye, Magali et al

in Neuropsychology (in press)

Objective: Huntington’s disease (HD) is characterized by motor and cognitive impairments including memory, executive, and attentional functions. However, because earlier studies relied on multidetermined ... [more ▼]

Objective: Huntington’s disease (HD) is characterized by motor and cognitive impairments including memory, executive, and attentional functions. However, because earlier studies relied on multidetermined attentional tasks, uncertainty still abounds regarding the differential deficit across attentional subcomponents. Likewise, the evolution of these deficits during the successive stages of HD remains unclear. The present study simultaneously explored 3 distinct networks of attention (alerting, orienting, executive conflict) in preclinical and clinical HD. Method: Thirty-eight HD patients (18 preclinical) and 38 matched healthy controls completed the attention network test, an integrated and theoretically grounded task assessing the integrity of 3 attentional networks. Results: Preclinical HD was not characterized by any attentional deficit compared to controls. Conversely, clinical HD was associated with a differential deficit across the 3 attentional networks under investigation, showing preserved performance for alerting and orienting networks but massive and specific impairment for the executive conflict network. This indexes an impaired use of executive control to resolve the conflict between task-relevant stimuli and interfering task-irrelevant ones. Conclusion: Clinical HD does not lead to a global attentional deficit but rather to a specific impairment for the executive control of attention. Moreover, the absence of attentional deficits in preclinical HD suggests that these deficits are absent at the initial stages of the disease. In view of their impact on everyday life, attentional deficits should be considered in clinical contexts. Therapeutic programs improving the executive control of attention by neuropsychology and neuromodulation should be promoted. [less ▲]

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See detailGrowth intention and sales revenues growth in small business: The mediating effect of firm size growth
Cesinger, Beate; Gundolf, Katherine; Geraudel, Mickaël UL

in International Journal of Technology Management (in press)

While the direct influence of growth intention on small business growth has been examined in entrepreneurship literature, little research distinguishes the different forms of growth and how they are ... [more ▼]

While the direct influence of growth intention on small business growth has been examined in entrepreneurship literature, little research distinguishes the different forms of growth and how they are interrelated. This article draws upon growth intention to examine whether firm size growth is the channel through which growth intention influences sales revenue growth. Results from the analysis of a dataset of 20,472 French new ventures reveal that: (1) growth intention has a positive impact on sales revenue growth; (2) firm size growth has a positive impact on sales revenue growth; and (3) firm size growth mediates the effect of growth intention on sales revenue growth. These findings show that firm size growth is a means to achieve sales revenue growth and not only a finality per se. [less ▲]

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See detailGender-specific expression of ubiquitin-specific peptidase 9 modulates tau expression and phosphorylation: possible implications for tauopathies
Köglsberger, Sandra UL; Cordero Maldonado, Maria Lorena UL; Antony, Paul UL et al

in Molecular Neurobiology (in press)

Public transcriptomics studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal ... [more ▼]

Public transcriptomics studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public post mortem brain tissue from Alzheimer’s disease (AD) patients compared to controls. We identify the sex-linked ubiquitin specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific under-expression in AD. Since previous studies have shown that USP9 can modulate the phosphorylation of the AD-associated protein MAPT, we investigate functional associations between USP9 and MAPT in further detail. After observing a high positive correlation between the expression of USP9 and MAPT in the public transcriptomics data, we show that USP9 knockdown results in significantly decreased MAPT expression in a DU145 cell culture model and a concentration-dependent decrease for the MAPT orthologs mapta and maptb in a zebrafish model. From the analysis of microarray and qRT-PCR experiments for the knockdown in DU145 cells and prior knowledge from the literature, we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4. Overall, the analyses suggest USP9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate MAPT expression. [less ▲]

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See detailConversion of non-proliferating astrocytes into neurogenic neural stem cells: control by FGF2 and IFN-gamma
Kleiderman, Susanne; Gutbier, Simon; Tufekci, Kemal U. et al

in Stem Cells (in press)

Conversion of astrocytes to neurons, via de-differentiation to neural stem cells (NSC), may be a new approach to treat neurodegenerative diseases and brain injuries. The signaling factors affecting such a ... [more ▼]

Conversion of astrocytes to neurons, via de-differentiation to neural stem cells (NSC), may be a new approach to treat neurodegenerative diseases and brain injuries. The signaling factors affecting such a cell conversion are poorly understood, and they are hard to identify in complex disease models or conventional cell cultures. To address this question, we developed a serum-free, strictly controlled culture system of pure and homogeneous ‘astrocytes generated form murine embryonic stem cells (ESC)’. These stem cell derived astrocytes (mAGES), as well as standard primary astrocytes resumed proliferation upon addition of FGF. The signaling of FGF receptor tyrosine kinase converted GFAP-positive mAGES to nestin-positive NSC. ERK phosphorylation was necessary, but not sufficient, for cell cycle re-entry, as EGF triggered no de-differentiation. The NSC obtained by de-differentiation of mAGES were similar to those obtained directly by differentiation of ESC, as evidenced by standard phenotyping, and also by transcriptome mapping, metabolic profiling, and by differentiation to neurons or astrocytes. The de-differentiation was negatively affected by inflammatory mediators, and in particular, interferon gamma (IFNγ) strongly impaired the formation of NSC from mAGES by a pathway involving phosphorylation of STAT1, but not the generation of nitric oxide. Thus, two antagonistic signaling pathways were identified here that affect fate conversion of astrocytes independent of genetic manipulation. The complex interplay of the respective signaling molecules that promote/inhibit astrocyte de-differentiation may explain why astrocytes do not readily form neural stem cells in most diseases. Increased knowledge of such factors may provide therapeutic opportunities to favor such conversions. [less ▲]

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See detailTeachers’ assessment competence: Integrating knowledge-, process-, and product-oriented approaches into a competence-oriented conceptual model
Herppich, Stephanie; Praetorius, Anna-Katharina; Hetmanek, Andreas et al

in Teaching and Teacher Education (in press)

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See detailInternet Gaming Disorder as a formative construct: Implications for conceptualization and measurement.
van Rooij, Antonius J.; Van Looy, Jan; Billieux, Joël UL

in Psychiatry and clinical neurosciences (in press)

Some people have serious problems controlling their Internet and video game use. The DSM-5 now includes a proposal for 'Internet Gaming Disorder' (IGD) as a condition in need of further study. Various ... [more ▼]

Some people have serious problems controlling their Internet and video game use. The DSM-5 now includes a proposal for 'Internet Gaming Disorder' (IGD) as a condition in need of further study. Various studies aim to validate the proposed diagnostic criteria for IGD and multiple new scales have been introduced that cover the suggested criteria. Using a structured approach, we demonstrate that IGD might be better interpreted as a formative construct, as opposed to the current practice of conceptualizing it as a reflective construct. Incorrectly approaching a formative construct as a reflective one causes serious problems in scale development, including: (i) incorrect reliance on item-to-total scale correlation to exclude items and incorrectly relying on indices of inter-item reliability that do not fit the measurement model (e.g., Cronbach's alpha); (ii) incorrect interpretation of composite or mean scores that assume all items are equal in contributing value to a sum score; and (iii) biased estimation of model parameters in statistical models. We show that these issues are impacting current validation efforts through two recent examples. A reinterpretation of IGD as a formative construct has broad consequences for current validation efforts and provides opportunities to reanalyze existing data. We discuss three broad implications for current research: (i) composite latent constructs should be defined and used in models; (ii) item exclusion and selection should not rely on item-to-total scale correlations; and (iii) existing definitions of IGD should be enriched further. [less ▲]

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See detailProduktinnovation in Start-ups: Die Rolle der Gründungsmotivationen von Unternehmern
Gast, Johanna; Gundolf, Katherine; Geraudel, Mickaël UL

in ZfKE : Zeitschrift für KMU und Entrepreneurship (in press)

Da Unternehmertum und Innovationen stark miteinander verknüpft sind, wird in dieser Studie der Zusammenhang zwischen ursprünglichen Gründungsmotivationen von Unternehmern und deren tatsächlichen ... [more ▼]

Da Unternehmertum und Innovationen stark miteinander verknüpft sind, wird in dieser Studie der Zusammenhang zwischen ursprünglichen Gründungsmotivationen von Unternehmern und deren tatsächlichen Produktinnovationen innerhalb der ersten Gründungsjahre untersucht. Basierend auf einer Stichprobe der französischen SINE Datenbank, welche von dem französischen Nationalen Institut für Statistik und Wirtschaftsplanung zur Verfügung gestellt wurde, wird gezeigt, dass verschiedene Gründungsmotivationen das Produktinnovationsverhalten von Start-ups positiv beeinflussen und dass Gründungsmotivationen damit auch nach der Gründung noch Nachfolgen haben können. So zeigen die Ergebnisse, dass Gründungsmotivationen wie unternehmerisches Denken und Handeln, Verbessern der finanziellen Position, Nutzen einer Geschäftschance oder –Idee und Arbeitslosigkeit einen signifikant positiven Effekt auf Produktinnovation im frisch gegründeten Unternehmen ausüben. [less ▲]

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See detailContainers for portable, productive and performant scientific computing
Hale, Jack UL; Li, Lizao; Richardson, Chris N. et al

in Computing in Science & Engineering (in press)

Containers are an emerging technology that hold promise for improving productivity and code portability in scientific computing. We examine Linux container technology for the distribution of a non-trivial ... [more ▼]

Containers are an emerging technology that hold promise for improving productivity and code portability in scientific computing. We examine Linux container technology for the distribution of a non-trivial scientific computing software stack and its execution on a spectrum of platforms from laptop computers through to high performance computing (HPC) systems. We show on a workstation and a leadership-class HPC system that when deployed appropriately there are no performance penalties running scientific programs inside containers. For Python code run on large parallel computers, the run time is reduced inside a container due to faster library imports. The software distribution approach and data that we present will help developers and users decide on whether container technology is appropriate for them. We also provide guidance for the vendors of HPC systems that rely on proprietary libraries for performance on what they can do to make containers work seamlessly and without performance penalty. [less ▲]

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See detailConcentration bounds for geometric Poisson functionals: logarithmic Sobolev inequalities revisited
Peccati, Giovanni UL; Bachmann, Sascha

in Electronic Journal of Probability (in press)

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See detailLabour, Gender and Ethnicities in the 'Heart of Manila'
Espinosa, Shirlita Africa UL

in Journal of Sociology (in press)

Manila, like most cities in the developing world, is experiencing the effects of the flexibility of global capital and the consequences of being excluded from the flows of knowledge and finance. Quaipo ... [more ▼]

Manila, like most cities in the developing world, is experiencing the effects of the flexibility of global capital and the consequences of being excluded from the flows of knowledge and finance. Quaipo, the 'heart of Manila', has responded to and negotiates with macroeconomic challenges through the underground economy of media piracy. Given the increase in population, unemployment and the general degradation of urban living amongst the poor, the economy of piracy has become a conduit of socio-economic changes that intersect with the culture-specific economy of worship. Quiapo is a fascinating terrain of Manilenos social history; it is the site of class tension, religious and ethnic divide, state intervention, and urban culture. Today, piracy and worship are forces by which the district's inhabitants and pilgrims define their lives and their labour. This essay examines how piracy and worship impact on the labour, space and gender dynamics of Quiapo. [less ▲]

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See detailNormative und nicht-normative Übergänge und Lebensereignisse im Lebenslauf und ihre Bedeutung für die Anpassung im Alter
Ferring, Dieter UL

in Psychotherapie im Alter (in press)

The paper (in German) proposes a systematic of transitions and events within the life course and describes their significance for adaptive processes in old age. Moreover, the importance of cognitive ... [more ▼]

The paper (in German) proposes a systematic of transitions and events within the life course and describes their significance for adaptive processes in old age. Moreover, the importance of cognitive evaluation as well as representation of such events for self-regulation are elaborated. A systemic approach is proposed to highlight the significance of family values for individual perception and evaluation processes. The potential applications for counselling and therapy such an approach may provide are outlined in the conclusion. [less ▲]

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See detailThree-dimensional remeshed smoothed particle hydrodynamics for the simulation of isotropic turbulence International Journal for Numerical Methods in Fluids
Obeidat, Anas UL; Bordas, Stéphane UL

in INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS (in press)

We present a remeshed particle-mesh method for the simulation of three-dimensional compressible turbulent flow. The method is related to the mesh free smoothed particle hydrodynamic (SPH) method, but the ... [more ▼]

We present a remeshed particle-mesh method for the simulation of three-dimensional compressible turbulent flow. The method is related to the mesh free smoothed particle hydrodynamic (SPH) method, but the present method introduces a mesh for efficient calculation of the pressure gradient, and laminar and turbulent diffusion. In addition, the mesh is used to remesh (reorganise uniformly) the particles to ensure a regular particle distribution and convergence of the method. The accuracy of the presented methodology is tested for a number of benchmark problems involving two- and three-dimensional Taylor-Green flow, thin double shear layer, and three-dimensional isotropic turbulence. Two models were implemented, direct numerical simulations, and Smagorinsky model. Taking advantage of the Lagrangian advection, and the finite difference efficiency, the method is capable of providing quality simulations while maintaining its robustness and versatility. [less ▲]

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See detailAugmenting Field Data for Testing Systems Subject to Incremental Requirements Changes
Di Nardo, Daniel; Pastore, Fabrizio; Briand, Lionel UL

in ACM Transactions on Software Engineering & Methodology (in press)

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See detailUnderstanding the evolution of coopetition among SMEs in a wine cluster: A social capital approach
Granata, Julien; Geraudel, Mickaël UL; Nicolosi, Alessandro et al

in International Journal of Entrepreneurship and Small Business (in press)

Research on small and medium-sized enterprises (SMEs) has done little to explore the drivers of coopetition. However, this issue is crucial for practitioners in charge of implementing the coopetition ... [more ▼]

Research on small and medium-sized enterprises (SMEs) has done little to explore the drivers of coopetition. However, this issue is crucial for practitioners in charge of implementing the coopetition process. We address this gap by exploring the drivers of coopetition among SMEs through a longitudinal case study based on 34 interviews along with informal conversations in the French wine cluster of Pic Saint-Loup. We find that the coopetition process (1) occurs in stages driven by specific environmental factors and (2) is facilitated by the social capital of cluster members, particularly the central member (owner-manager), which is key to the success of each coopetition stage. Our results provide a better understanding of wine cluster development and the inducement of SME coopetition. [less ▲]

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See detailHi-POD solution of parametrized fluid dynamics problems: preliminary results
Baroli, Davide UL; Cova, Maria Cristina; Perotto, Simona et al

in MS&A series (in press), MS&A series

Numerical modeling of fluids in pipes or network of pipes (like in the circulatory system) has been recently faced with new methods that exploit the specific nature of the dynamics, so that a one ... [more ▼]

Numerical modeling of fluids in pipes or network of pipes (like in the circulatory system) has been recently faced with new methods that exploit the specific nature of the dynamics, so that a one dimensional axial mainstream is enriched by local secondary transverse components [4, 16, 18]. These methods - under the name of Hi-Mod approximation - construct a solution as a finite element axial discretization, completed by a spectral approximation of the transverse dynamics. It has been demonstrated that Hi-Mod reduction significantly accelerates the computations without com- promising the accuracy. In view of variational data assimilation procedures (or, more in general, control problems), it is crucial to have efficient model reduction techniques to rapidly solve, for instance, a parametrized problem for several choices of the parameters of interest. In this work, we present some preliminary results merging Hi-Mod techniques with a classical Proper Orthogonal Decomposition (POD) strategy. We name this new approach as Hi-POD model reduction. We demonstrate the efficiency and the reliability of Hi-POD on multiparameter advection-diffusion-reaction problems as well as on the incompressible Navier-Stokes equations, both in a steady and in an unsteady setting. [less ▲]

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See detailGaussian Phase Transitions and Conic Intrinsic Volumes: Steining the Steiner Formula
Goldstein, Larry; Nourdin, Ivan UL; Peccati, Giovanni UL

in Annals of Applied Probability (in press)

Intrinsic volumes of convex sets are natural geometric quantities that also play important roles in applications, such as linear inverse problems with convex constraints, and constrained statistical ... [more ▼]

Intrinsic volumes of convex sets are natural geometric quantities that also play important roles in applications, such as linear inverse problems with convex constraints, and constrained statistical inference. It is a well-known fact that, given a closed convex cone $C\subset \mathbb{R}^d$, its conic intrinsic volumes determine a probability measure on the finite set $\{0,1,...d\}$, customarily denoted by $\mathcal{L}(V_C)$. The aim of the present paper is to provide a Berry-Esseen bound for the normal approximation of ${\cal L}(V_C)$, implying a general quantitative central limit theorem (CLT) for sequences of (correctly normalised) discrete probability measures of the type $\mathcal{L}(V_{C_n})$, $n\geq 1$. This bound shows that, in the high-dimensional limit, most conic intrinsic volumes encountered in applications can be approximated by a suitable Gaussian distribution. Our approach is based on a variety of techniques, namely: (1) Steiner formulae for closed convex cones, (2) Stein's method and second order Poincar\'e inequality, (3) concentration estimates, and (4) Fourier analysis. Our results explicitly connect the sharp phase transitions, observed in many regularised linear inverse problems with convex constraints, with the asymptotic Gaussian fluctuations of the intrinsic volumes of the associated descent cones. In particular, our findings complete and further illuminate the recent breakthrough discoveries by Amelunxen, Lotz, McCoy and Tropp (2014) and McCoy and Tropp (2014) about the concentration of conic intrinsic volumes and its connection with threshold phenomena. As an additional outgrowth of our work we develop total variation bounds for normal approximations of the lengths of projections of Gaussian vectors on closed convex sets. [less ▲]

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See detailAssessing suffering in experimental pain models: psychological and psychophysiological correlates
Brunner, Michael; Kamping, Sandra; Bustan, Smadar et al

in Journal of Psychology (in press)

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See detailHow Do Institutional Logics Evolve Over the Merger Process? A Case in the Public-Private Urban Planning Sector
Thelisson, Anne-Sophie; Geraudel, Mickaël UL; Missonier, Audrey

in Strategic Change (in press)

We present an analysis of the institutional logics rivalries during a merger process. We performed an in-depth longitudinal analysis of a private-public merger between two listed companies in the town ... [more ▼]

We present an analysis of the institutional logics rivalries during a merger process. We performed an in-depth longitudinal analysis of a private-public merger between two listed companies in the town planning sector. The case study was based on passive and participant observations over two years, 54 semi-structured interviews and archival records analysis. We underline that the implementation of strategic change during the merger process was fostered by the ability of the actors to combine institutional logics through three concrete practices: redefining the authority, identity and legitimacy of the new organization. We contribute to the refining of the merger literature by offering insights from the institutional logics perspective and provide managerial recommendations to facilitate the post-merger integration process. [less ▲]

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See detailPension Insecurity and Wellbeing in Europe
Olivera, Javier; Ponomarenko, Valentina UL

in Journal of Social Policy (in press)

This paper studies pension insecurity in a sample of non-retired individuals aged 50 years or older from 18 European countries. We capture pension insecurity with the subjective expectations on the ... [more ▼]

This paper studies pension insecurity in a sample of non-retired individuals aged 50 years or older from 18 European countries. We capture pension insecurity with the subjective expectations on the probability that the government will reduce the pensions of the individual before retirement or will increase the statutory retirement age. We argue that changes in economic conditions and policy affect the formation of such probabilities, and through this, subjective wellbeing. In particular, we study the effects of pension insecurity on subjective wellbeing with pooled linear models, regressions per quintiles and instrumental variables. We find a statistically significant, stable and negative association between pension insecurity and subjective wellbeing. Our findings reveal that the individuals who are more affected by pension insecurity are those who are further away fromtheir retirement, have lower income, assess their life survival as low, have higher cognitive abilities and do not expect private pension payments. [less ▲]

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See detailA Meta-Analysis of Viewing Time Measures of Sexual Interest in Children
Schmidt, Alexander F. UL; Babchishin, Kelly M.; Lehmann, Robert J. B.

in Archives of Sexual Behavior (in press)

Due to unobtrusiveness and ease of implementation, viewing time (VT) measures of sexual interest in children have sparked increasing research interest in forensic contexts over the last two decades. The ... [more ▼]

Due to unobtrusiveness and ease of implementation, viewing time (VT) measures of sexual interest in children have sparked increasing research interest in forensic contexts over the last two decades. The current study presents two meta-analyses of VT measures adapted to assess pedophilic interest to determine their discrimination between sexual offenders against children (SOC) and non-SOC groups as well as convergent validity (associations with other measures of sexual interest in children). On average, VT measures showed moderate discrimination between criterion groups (fixed-effect d = 0.60, 95% CI [0.51, 0.68], N = 2,705, k = 14) and significant convergent validity with self-reports, penile plethysmography, Implicit Association Tests and offence behavioral measures ranging from r =.18 to r = .38. VT measures, however, provided better discrimination for adults (fixed-effect d = 0.78, 95% CI [0.64, 0.92]) than adolescent samples (fixed-effect d = 0.50, 95% CI [0.40, 0.61]), Qbetween = 9.37, p = .002. Moreover, using pedophilic difference scores within adult samples substantially increased VT measures’ validity (fixed-effect d = 1.03, 95% CI [0.82, 1.25], N = 414, k = 7). Results are discussed in terms of their theoretical and applied implications for forensic contexts. [less ▲]

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See detailAutomated Extraction and Clustering of Requirements Glossary Terms
Arora, Chetan UL; Sabetzadeh, Mehrdad UL; Briand, Lionel UL et al

in IEEE Transactions on Software Engineering (in press)

A glossary is an important part of any software requirements document. By making explicit the technical terms in a domain and providing definitions for them, a glossary helps mitigate imprecision and ... [more ▼]

A glossary is an important part of any software requirements document. By making explicit the technical terms in a domain and providing definitions for them, a glossary helps mitigate imprecision and ambiguity. A key step in building a glossary is to decide upon the terms to include in the glossary and to find any related terms. Doing so manually is laborious, particularly for large requirements documents. In this article, we develop an automated approach for extracting candidate glossary terms and their related terms from natural language requirements documents. Our approach differs from existing work on term extraction mainly in that it clusters the extracted terms by relevance, instead of providing a flat list of terms. We provide an automated, mathematically-based procedure for selecting the number of clusters. This procedure makes the underlying clustering algorithm transparent to users, thus alleviating the need for any user-specified parameters. To evaluate our approach, we report on three industrial case studies, as part of which we also examine the perceptions of the involved subject matter experts about the usefulness of our approach. Our evaluation notably suggests that: (1) Over requirements documents, our approach is more accurate than major generic term extraction tools. Specifically, in our case studies, our approach leads to gains of 20% or more in terms of recall when compared to existing tools, while at the same time either improving precision or leaving it virtually unchanged. And, (2) the experts involved in our case studies find the clusters generated by our approach useful as an aid for glossary construction. [less ▲]

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See detailDiversifizierung von Kindertagesbetreuungsangeboten durch mixed economy of care: Eine vergleichende Perspektive aus Luxemburg und Deutschland.
Schmitz, Anett UL; Wiltzius, Martine UL; Mierendorff, Johanna

in Zeitschrift für Soziologie der Erziehung und Sozialisation = Journal for Sociology of Education and Socialization (in press)

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See detailBouded Discretion in EU Law: A limited Judicial Paradigm in a Changing EU
Mendes, Joana UL

in Modern Law Review (in press)

The strengthening of the EU executive following the post-2008 reforms of economic and financial market regulation has unveiled the tensions of the relation between law and discretion. This article ... [more ▼]

The strengthening of the EU executive following the post-2008 reforms of economic and financial market regulation has unveiled the tensions of the relation between law and discretion. This article deconstructs a prevailing distinction between discretion to make policy choices and discretion in conducting technical assessments, which stems from a judicial paradigm of discretion. Such distinction has contributed to the re-allocation of authority in the EU (eg ESMA and Gauweiler). The article traces its roots in doctrinal constructions that have shaped legal administrative thinking since the early times of the Etat de Droit or Rechstaat. It proposes a public interest-regarding conception of discretion that, in an institutional context where courts may have a limited reviewing role, approaches the relation of discretion to law as a matter of how legal norms may operate in the spaces of discretion that they attribute to decision-makers, rather than as a matter of how courts may review discretion. [less ▲]

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See detailResearch Organizations' Contributions to Science Productivity in Science, Technology, Engineering and Mathematics in Germany, France, Belgium, and Luxembourg
Powell, Justin J W UL; Dusdal, Jennifer UL

in Minerva: A Review of Science, Learning and Policy (in press)

Charting significant growth in scientific productivity over the 20th century in four EU member states, this neo-institutional analysis describes the development and current state of universities and ... [more ▼]

Charting significant growth in scientific productivity over the 20th century in four EU member states, this neo-institutional analysis describes the development and current state of universities and research institutes that bolsters Europe’s position as a key region in global science. On-going internationalization and Europeanization of higher education and science has been accompanied by increasing competition as well as collaboration. Despite the political goals to foster innovation and further expand research capacity, in cross-national and historical comparison, neither the level of R&D investments nor country size accounts completely for the differential growth of scientific productivity. Based on a comprehensive historical database, this analysis uncovers both stable and dynamic patterns of productivity from 1975 to 2010 in Ger- many, France, Belgium, and Luxembourg. Measured in peer-reviewed research articles collected in Thomson Reuters Science Citation Index Expanded (SCIE), we show the varying contributions of different organizational forms, especially research universities and research institutes. Comparing the institutionalization pathways that created the conditions necessary for continuous and strong growth in scientific productivity in the European center of global science emphasizes that the research university is key organizational form across countries. [less ▲]

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See detailIterative observer-based state and parameter estimation for linear systems
Aalto, Atte UL

in ESAIM: Control, Optimisation and Calculus of Variations (in press)

We propose an iterative method for joint state and parameter estimation using measurements on a time interval [0,T] for systems that are backward output stabilizable. Since this time interval is fixed ... [more ▼]

We propose an iterative method for joint state and parameter estimation using measurements on a time interval [0,T] for systems that are backward output stabilizable. Since this time interval is fixed, errors in initial state may have a big impact on the parameter estimate. We propose to use the back and forth nudging (BFN) method for estimating the system’s initial state and a Gauss–Newton step between BFN iterations for estimating the system parameters. Taking advantage of results on the optimality of the BFN method, we show that for systems with skew-adjoint generators, the initial state and parameter estimate minimizing an output error cost functional is an attractive fixed point for the proposed method. We treat both linear source estimation and bilinear parameter estimation problems. [less ▲]

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See detailArts vs Engineering: Choosing Consumption of and Investment in Education
Tampieri, Alessandro UL; Romano, Richard

in Research in Economics (in press)

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See detailSecurity Slicing for Auditing Common Injection Vulnerabilities
Thome, Julian UL; Shar, Lwin Khin UL; Bianculli, Domenico UL et al

in The Journal of Systems & Software (in press)

Cross-site scripting and injection vulnerabilities are among the most common and serious security issues for Web applications. Although existing static analysis approaches can detect potential ... [more ▼]

Cross-site scripting and injection vulnerabilities are among the most common and serious security issues for Web applications. Although existing static analysis approaches can detect potential vulnerabilities in source code, they generate many false warnings and source-sink traces with irrelevant information, making their adoption impractical for security auditing. One suitable approach to support security auditing is to compute a program slice for each sink, which contains all the information required for security auditing. However, such slices are likely to contain a large amount of information that is irrelevant to security, thus raising scalability issues for security audits. In this paper, we propose an approach to assist security auditors by defining and experimenting with pruning techniques to reduce original program slices to what we refer to as security slices, which contain sound and precise information. To evaluate the proposed approach, we compared our security slices to the slices generated by a state-of-the-art program slicing tool, based on a number of open-source benchmarks. On average, our security slices are 76% smaller than the original slices. More importantly, with security slicing, one needs to audit approximately 1% of the total code to fix all the vulnerabilities, thus suggesting significant reduction in auditing costs. [less ▲]

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See detailA remark on Schröder's equation: Formal and analytic linearization of iterative roots of the power series f(z)=z
Reich, Ludwig; Tomaschek, Jörg UL

in Monatshefte für Mathematik (in press)

We study Schröder’s equation (i.e. the problem of linearization) for local analytic functions F with F (0)=0, F(0)=1, F(0) a root of 1. While Schröder’s equation in this case need not have even a formal ... [more ▼]

We study Schröder’s equation (i.e. the problem of linearization) for local analytic functions F with F (0)=0, F(0)=1, F(0) a root of 1. While Schröder’s equation in this case need not have even a formal solution, we show that if F is formally linearizable, then it can also be linearized by an invertible local analytic transformation. On the other hand, there exist also divergent series solutions of Schröder’s equation in this situation. We give some applications of our results to iterative functional equations, functional-differential equations and iteration groups. [less ▲]

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See detailBoundlessly Entangled: Travels and Performances of School Hygiene in the Context of Open-Air Education (c. 1904-1936)
Thyssen, Geert UL

in Canadian Bulletin of Medical History (in press)

This article develops a histoire croisée of health education using the example of open-air schools. It reflexively analyses the entangled performances of knowledge and praxis around hygiene in the context ... [more ▼]

This article develops a histoire croisée of health education using the example of open-air schools. It reflexively analyses the entangled performances of knowledge and praxis around hygiene in the context of “international” open-air school conferences and in relation to “materials” of open-air education. Such performances reveal open-air schools as “practice and movement” unbound by “national” or otherwise imagined borders. Fragmentation accompanied their circulation and ensued from non/humans’ active, co-constitutive role in the mediation of knowledge and praxis. While underexplored, material and economic factors were key to this process. Their analysis enriches the study of the “internationalization” of school hygiene. [less ▲]

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See detailModel-Based Simulation of Legal Policies: Framework, Tool Support, and Validation
Soltana, Ghanem UL; Sannier, Nicolas UL; Sabetzadeh, Mehrdad UL et al

in Software & Systems Modeling (in press)

Simulation of legal policies is an important decision-support tool in domains such as taxation. The primary goal of legal policy simulation is predicting how changes in the law affect measures of interest ... [more ▼]

Simulation of legal policies is an important decision-support tool in domains such as taxation. The primary goal of legal policy simulation is predicting how changes in the law affect measures of interest, e.g., revenue. Legal policy simulation is currently implemented using a combination of spreadsheets and software code. Such a direct implementation poses a validation challenge. In particular, legal experts often lack the necessary software background to review complex spreadsheets and code. Consequently, these experts currently have no reliable means to check the correctness of simulations against the requirements envisaged by the law. A further challenge is that representative data for simulation may be unavailable, thus necessitating a data generator. A hard-coded generator is difficult to build and validate. We develop a framework for legal policy simulation that is aimed at addressing the challenges above. The framework uses models for specifying both legal policies and the probabilistic characteristics of the underlying population. We devise an automated algorithm for simulation data generation. We evaluate our framework through a case study on Luxembourg’s Tax Law. [less ▲]

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See detailToward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research
Maes; Nowak, Gabriel; Caso, Javier et al

in Molecular Neurobiology (in press)

Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g ... [more ▼]

Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g., interleukin-6. Supporting the translational significance of this, a meta-analysis showed that anti-inflammatory drugs may have antidepressant effects. Here, we argue that inflammation and depression research needs to get onto a new track. Firstly, the choice of inflammatory biomarkers in depression research was often too selective and did not consider the broader pathways. Secondly, although mild inflammatory responses are present in depression, other immune-related pathways cannot be disregarded as new drug targets, e.g., activation of cell-mediated immunity, oxidative and nitrosative stress (O&NS) pathways, autoimmune responses, bacterial translocation, and activation of the toll-like receptor and neuroprogressive pathways. Thirdly, anti-inflammatory treatments are sometimes used without full understanding of their effects on the broader pathways underpinning depression. Since many of the activated immune-inflammatory pathways in depression actually confer protection against an overzealous inflammatory response, targeting these pathways may result in unpredictable and unwanted results. Furthermore, this paper discusses the required improvements in research strategy, i.e., path and drug discovery processes, omics-based techniques, and systems biomedicine methodologies. Firstly, novel methods should be employed to examine the intracellular networks that control and modulate the immune, O&NS and neuroprogressive pathways using omics-based assays, including genomics, transcriptomics, proteomics, metabolomics, epigenomics, immunoproteomics and metagenomics. Secondly, systems biomedicine analyses are essential to unravel the complex interactions between these cellular networks, pathways, and the multifactorial trigger factors and to delineate new drug targets in the cellular networks or pathways. Drug discovery processes should delineate new drugs targeting the intracellular networks and immune-related pathways. [less ▲]

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See detailOn the choice of a phase interchange strategy for a multiscale DEM-VOF Method
Pozzetti, Gabriele UL; Peters, Bernhard UL

in AIP Conference Proceedings (in press)

In this work a novel Multiscale DEM-VOF method is adopted to study three phase flows. It consists in solving the fluid momentum, mass conservation and the phase advection at a different scale with respect ... [more ▼]

In this work a novel Multiscale DEM-VOF method is adopted to study three phase flows. It consists in solving the fluid momentum, mass conservation and the phase advection at a different scale with respect to the fluid-particle coupling problem. This allows the VOF scheme to resolve smaller fluid structures than a classic DEM-VOF method, and opens the possibility of adopting different volume interchange techniques. Two different volume interchange techniques are here described and compared with reference to high and low particle concentration scenarios. Considerations about the respective computational costs are also proposed. [less ▲]

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See detailGuaranteed error bounds in homogenisation: an optimum stochastic approach to preserve the numerical separation of scales
Paladim, Daniel-Alves; de Almeida, José Paulo Baptista; Bordas, Stéphane UL et al

in International Journal for Numerical Methods in Engineering (in press)

This paper proposes a new methodology to guarantee the accuracy of the homogenisation schemes that are traditionally employed to approximate the solution of PDEs with random, fast evolving diffusion ... [more ▼]

This paper proposes a new methodology to guarantee the accuracy of the homogenisation schemes that are traditionally employed to approximate the solution of PDEs with random, fast evolving diffusion coefficients. We typically consider linear elliptic diffusion problems in randomly packed particulate composites. Our work extends the pioneering work presented in [26,32] in order to bound the error in the expectation and second moment of quantities of interest, without ever solving the fine-scale, intractable stochastic problem. The most attractive feature of our approach is that the error bounds are computed without any integration of the fine-scale features. Our computations are purely macroscopic, deterministic, and remain tractable even for small scale ratios. The second contribution of the paper is an alternative derivation of modelling error bounds through the Prager-Synge hypercircle theorem. We show that this approach allows us to fully characterise and optimally tighten the interval in which predicted quantities of interest are guaranteed to lie. We interpret our optimum result as an extension of Reuss-Voigt approaches, which are classically used to estimate the homogenised diffusion coefficients of composites, to the estimation of macroscopic engineering quantities of interest. Finally, we make use of these derivations to obtain an efficient procedure for multiscale model verification and adaptation. [less ▲]

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See detailNetwork proximity in the geography of research collaboration
Berge, Laurent UL

in Papers in Regional Science (in press)

This paper deals with the questions of how network proximity influences the structure of inter-regional collaborations and how it interacts with geography. I first introduce a new, theoretically grounded ... [more ▼]

This paper deals with the questions of how network proximity influences the structure of inter-regional collaborations and how it interacts with geography. I first introduce a new, theoretically grounded measure of inter-regional network proximity. Then, I use data on European scientific co-publications in the field of chemistry between 2001 and 2005 to assess those questions. The main findings reveal that inter-regional network proximity is important in determining future collaborations but its effect is mediated by geography. Most importantly, a clear substitution pattern is revealed showing that network proximity mainly benefits international collaborations. [less ▲]

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See detailMolecular Identification of D-Ribulokinase in Budding Yeast and Mammals
Singh, Charandeep UL; Glaab, Enrico UL; Linster, Carole UL

in Journal of Biological Chemistry (in press)

Proteomes of even well characterized organisms still contain a high percentage of proteins with unknown or uncertain molecular and/or biological function. A significant fraction of those proteins are ... [more ▼]

Proteomes of even well characterized organisms still contain a high percentage of proteins with unknown or uncertain molecular and/or biological function. A significant fraction of those proteins are predicted to have catalytic properties. Here we aimed at identifying the function of the Saccharomyces cerevisiae Ydr109c protein and of its human homolog FGGY, both of which belong to the broadly conserved FGGY family of carbohydrate kinases. Functionally identified members of this family phosphorylate 3- to 7-carbon sugars or sugar derivatives, but the endogenous substrate of S. cerevisiae Ydr109c and human FGGY has remained unknown. Untargeted metabolomics analysis of an S. cerevisiae deletion mutant of YDR109C revealed ribulose as one of the metabolites with the most significantly changed intracellular concentration as compared to a wild-type strain. In human HEK293 cells, ribulose could only be detected when ribitol was added to the cultivation medium and under this condition, FGGY silencing led to ribulose accumulation. Biochemical characterization of the recombinant purified Ydr109c and FGGY proteins showed a clear substrate preference of both kinases for D-ribulose over a range of other sugars and sugar derivatives tested, including L-ribulose. Detailed sequence and structural analyses of Ydr109c and FGGY as well as homologs thereof furthermore allowed the definition of a 5-residue D-ribulokinase signature motif (TCSLV). The physiological role of the herein identified eukaryotic D-ribulokinase remains unclear, but we speculate that S. cerevisiae Ydr109c and human FGGY could act as metabolite repair enzymes, serving to re-phosphorylate free D-ribulose generated by promiscuous phosphatases from D-ribulose-5-phosphate. In human cells, FGGY can additionally participate in ribitol metabolism. [less ▲]

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See detailOn-line model-based fault detection and isolation for PEM fuel cell stack systems
Rosich, Albert UL; Sarrate, Ramon; Nejjari, Fatiha

in Applied Mathematical Modelling (in press)

Efficient and reliable operation of Polymer Electrolyte Membrane (PEM) fuel cells are key requirements for their successful commercialization and application. The use of diagnostic techniques enables the ... [more ▼]

Efficient and reliable operation of Polymer Electrolyte Membrane (PEM) fuel cells are key requirements for their successful commercialization and application. The use of diagnostic techniques enables the achievement of these requirements. This paper focuses on model-based fault detection and isolation (FDI) for PEM fuel cell stack systems. The work consists in designing and selecting a subset of consistency relations such that a set of predefined faults can be detected and isolated. Despite a nonlinear model of the PEM fuel cell stack system will be used, consistency relations that are easily implemented by a variable back substitution method will be selected. The paper also shows the significance of structural models to solve diagnosis issues in complex systems. [less ▲]

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See detailA Generic Approach for Solving Nonlinear-Discrete Security-Constrained Optimal Power Flow Problems in Large-Scale Systems
Platbrood, Ludovic; Capitanescu, Florin UL; Merckx, Christian et al

in IEEE Transactions on Power Systems (in press)

This paper proves the practicality of an iterative algorithm for solving realistic large-scale SCOPF problems. This algorithm is based on the combination of a contingency filtering scheme, used to ... [more ▼]

This paper proves the practicality of an iterative algorithm for solving realistic large-scale SCOPF problems. This algorithm is based on the combination of a contingency filtering scheme, used to identify the binding contingencies at the optimum, and a network compression method, used to reduce the complexity of the post-contingency models included in the SCOPF formulation. We show that by combining these two complementary ideas, it is possible to solve in a reasonable time SCOPF problems on large power system models with a large number of contingencies. Unlike most results reported for large-scale SCOPF problems, our algorithm uses a non-linear AC network model in both pre-contingency and post-contingency states, optimizes both active/reactive powers flows jointly, and treats the discrete variables. The proposed algorithm is implemented with state-of-the-art solvers and applied to two systems: a national grid with 2563 buses and 1297 contingencies, and a model of the European transmission network with 9241 buses and 12000 contingencies. [less ▲]

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See detailQuantitative de Jong theorems in any dimension
Döbler, Christian UL; Peccati, Giovanni UL

in Electronic Journal of Probability (in press)

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See detailCorrector in random homogenization of elliptic equations in presence of long-range media
Lechiheb, Atef; Nourdin, Ivan UL; Zheng, Guangqu UL et al

in Probability and Mathematical Statistics (in press)

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See detailRecent Results on Douglas–Rachford Methods for Combinatorial Optimization Problems
Aragón Artacho, Francisco Javier UL; Borwein, J. M.; Tam, M. K.

in Journal of Optimization Theory & Applications (in press)

We discuss recent positive experiences applying convex feasibility algorithms of Douglas-Rachford type to highly combinatorial and far from convex problems.

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See detailUnraveling Entangled Spaces and Practices: Teacher's Views on the evolving Material Classroom (c.1960-2015)
Tondeur, Jo; Herman, Frederik UL; De Buck, Maud et al

in European Journal of Education (in press)

Despite growing interest in redesigning the material landscape of education, relatively little is known about the impact of these evolving classrooms. The current study aimed to gain insight into the ... [more ▼]

Despite growing interest in redesigning the material landscape of education, relatively little is known about the impact of these evolving classrooms. The current study aimed to gain insight into the physical learning environment and the potential pedagogical impacts thereof. A ‘biographical approach’ (c.1963-2015), was used to explore the long-term socio-material landscapes where teachers and pupils, classroom materiality and spatiality, and teaching practices are entangled. Stimulated recall interviews were conducted in Flanders (Belgium) with primary school teachers. Teacher-generated floorplans detailing their material classroom over time, transcribed oral accounts elaborating on these, and supportive data sources were aggregated and thematically analysed. The resulting identification of six key themes shed light on the evolving architectural and infrastructural developments, as well as triggers and teaching impacts thereof amongst the interviewed teachers. Findings show that negative school evaluations urging school intervention, and teachers’ proactive engagement within their classrooms, were the main catalysts of change. Moreover, evolving classroom layouts, in addition to the affordances of upgraded equipment, can be associated to changes in teachers’ practices. It can be concluded that the classroom is becoming an action context as the result of the inextricable mediating agencies identified. [less ▲]

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See detailApplications of convex analysis within mathematics
Aragón Artacho, Francisco Javier UL; Borwein, J. M.; Martín-Márquez, V. et al

in Mathematical Programming (in press)

In this paper, we study convex analysis and its theoretical applications. We first apply important tools of convex analysis to Optimization and to Analysis. We then show various deep applications of ... [more ▼]

In this paper, we study convex analysis and its theoretical applications. We first apply important tools of convex analysis to Optimization and to Analysis. We then show various deep applications of convex analysis and especially infimal convolution in Monotone Operator Theory. Among other things, we recapture the Minty surjectivity theorem in Hilbert space, and present a new proof of the sum theorem in reflexive spaces. More technically, we also discuss autoconjugate representers for maximally monotone operators. Finally, we consider various other applications in mathematical analysis. [less ▲]

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See detailHow Do Different Aspects of Spatial Skills Relate to Early Arithmetic and Number Line Estimation?
Cornu, Véronique UL; Hornung, Caroline; Schiltz, Christine UL et al

in Journal of Numerical Cognition (in press)

The present study investigated the predictive role of spatial skills for arithmetic and number line estimation in kindergarten children (N = 125). Spatial skills are known to be related to mathematical ... [more ▼]

The present study investigated the predictive role of spatial skills for arithmetic and number line estimation in kindergarten children (N = 125). Spatial skills are known to be related to mathematical development, but due to the construct’s non-unitary nature, different aspects of spatial skills need to be differentiated. In the present study, a spatial orientation task, a spatial visualization task and visuo-motor integration task were administered to assess three different aspects of spatial skills. Furthermore, we assessed counting abilities, knowledge of Arabic numerals, quantitative knowledge, as well as verbal working memory and verbal intelligence in kindergarten. Four months later, the same children performed an arithmetic and a number line estimation task to evaluate how the abilities measured at time 1 predicted early mathematics outcomes. Hierarchical regression modelling revealed that children’s performance in arithmetic was predicted by their performance in the spatial orientation and Visuo-motor integration task, as well as their knowledge of the Arabic numerals. Performance in number line estimation was significantly predicted by the children’s spatial orientation performance. Our findings emphasize the role of spatial skills, notably spatial orientation, in mathematical development. The relation between spatial orientation and arithmetic was partially mediated by the number line estimation task. Our results further show that some aspects of spatial skills might be more predictive of mathematical development than others, underlining the importance to differentiate within the construct of spatial skills when it comes to understanding numerical development. [less ▲]

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See detailA minimal realization technique for the dynamical structure function of a class of LTI systems
Goncalves, Jorge UL; Yuan, Ye; Rai, Anurag et al

in IEEE Transactions on Control of Network Systems (in press)

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See detailStudents' immigration background as a moderator of predictive validity of tracking decisions.
Klapproth, Florian UL; Schaltz, Paule UL

in Procedia Social and Behavioral Sciences (in press)

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See detailReligious Affiliation and Attitudes Towards Gay Men: On the Mediating Role of Masculinity Threat
Reese, Gerhard UL; Steffens, Melanie C.; Jonas, Kai J.

in Journal of Community & Applied Social Psychology (in press)

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See detailSparse Network Identifiability via Compressed Sensing
Goncalves, Jorge UL; Hayden, David; Chang, Young et al

in Automatica (in press)

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See detailNetwork Identifiability from Intrinsic Noise
Goncalves, Jorge UL; Hayden, David; Yuan, Ye

in IEEE Transactions on Automatic Control (in press)

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See detailStrong ties, personality, and legitimacy of entrepreneurs: the case of private physicians
Gundolf, Katherine; Cesinger, Beate; Geraudel, Mickaël UL et al

in International Journal of Entrepreneurial Venturing (in press)

Legitimacy is crucial for entrepreneurs. It is the cornerstone for creating relationships with stakeholders and mitigating resource constraints. But, other-referent legitimacy is also related to the ... [more ▼]

Legitimacy is crucial for entrepreneurs. It is the cornerstone for creating relationships with stakeholders and mitigating resource constraints. But, other-referent legitimacy is also related to the cognitive image of individual legitimacy. Drawing on the identity-based model of legitimacy, we argue that personality traits (big five) and social capital (strong ties) of entrepreneurs impact self-perceived legitimacy of entrepreneurs. Based on survey data of 98 German private physicians, this paper examines antecedents of self-perceived legitimacy towards two main stakeholders: patients and peers. We find that high levels of agreeableness stimulate self-perceived legitimacy towards patients and peers, whereas openness to experience solely influences physicians’ self-perceived legitimacy towards patients. In addition, our results highlight the contingent effect of personality traits by underlining the role of strong ties as moderator of the relationship between personality traits and the self-perceived legitimacy. By identifying these configurations we contribute to the literature on entrepreneurship with a refined perspective of antecedents of self-perceived legitimacy. Moreover, we give recommendations on how private physicians can benefit from two personality traits – agreeableness and openness to experience – and how they can manage weak and strong ties in order to diffuse their reputation. [less ▲]

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See detailOn the eigenvariety of Hilbert modular forms at classical parallel weight one points with dihedral projective image
Deo, Shaunak UL

in Transactions of the American Mathematical Society (in press)

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See detailNitsche’s method for two and three dimensional NURBS patch coupling
Nguyen, Vinh-Phu; Kerfriden, Pierre; Brino, Marco et al

in Computational Mechanics (in press)

We present a Nitche’s method to couple non-conforming two and three-dimensional NURBS (Non Uniform Rational B-splines) patches in the context of isogeometric analysis (IGA). We present results for linear ... [more ▼]

We present a Nitche’s method to couple non-conforming two and three-dimensional NURBS (Non Uniform Rational B-splines) patches in the context of isogeometric analysis (IGA). We present results for linear elastostatics in two and and three-dimensions. The method can deal with surface-surface or volume-volume coupling, and we show how it can be used to handle heterogeneities such as inclusions. We also present preliminary results on modal analysis. This simple coupling method has the potential to increase the applicability of NURBS-based isogeometric analysis for practical applications. [less ▲]

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See detailAnalysis of composite plates through cell-based smoothed finite element and 4-noded mixed interpolation of tensorial components techniques
Rodrigues, JD; Natarajan, S; Ferreira, AJM et al

in Computers & Structures (in press)

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See detailSmoking related warning messages formulated as questions positively influence short-term smoking behaviour
Müller, Barbara; Ritter, Simone; Glock, Sabine UL et al

in Journal of Health Psychology (in press)

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See detailAn Automated Framework for Detection and Resolution of Cross References in Legal Texts
Sannier, Nicolas UL; Adedjouma, Morayo; Sabetzadeh, Mehrdad UL et al

in Requirements Engineering (in press)

When identifying and elaborating compliance requirements, analysts need to follow the cross references in legal texts and consider the additional information in the cited provisions. Enabling easier ... [more ▼]

When identifying and elaborating compliance requirements, analysts need to follow the cross references in legal texts and consider the additional information in the cited provisions. Enabling easier navigation and handling of cross references requires automated support for the detection of the natural language expressions used in cross references, the interpretation of cross references in their context, and the linkage of cross references to the targeted provisions. In this article, we propose an approach and tool sup- port for automated detection and resolution of cross references. The approach leverages the structure of legal texts, formalized into a schema, and a set of natural language patterns for legal cross reference expressions. These patterns were developed based on an investigation of Luxembourg’s legislation, written in French. To build confidence about their applicability beyond the context where they were observed, these patterns were validated against the Personal Health Information Protection Act (PHIPA) by the Government of Ontario, Canada, written in both French and English. We report on an empirical evaluation where we assess the accuracy and scalability of our framework over several Luxembourgish legislative texts as well as PHIPA. [less ▲]

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See detailHow can we conceptualize behavioural addiction without pathologizing common behaviours?
Kardefelt-Winther, Daniel; Heeren, Alexandre; Schimmenti, Adriano et al

in Addiction (in press)

Following the recent changes to the diagnostic category for addictive disorders in DSM-5, it is urgent to clarify what constitutes behavioural addiction to have a clear direction for future research and ... [more ▼]

Following the recent changes to the diagnostic category for addictive disorders in DSM-5, it is urgent to clarify what constitutes behavioural addiction to have a clear direction for future research and classification. However, in the years following the release of DSM-5, an expanding body of research has increasingly classified engagement in a wide range of common behaviours and leisure activities as possible behavioural addiction. If this expansion does not end, both the relevance and the credibility of the field of addictive disorders might be questioned, which may prompt a dismissive appraisal of the new DSM-5 subcategory for behavioural addiction. We propose an operational definition of behavioural addiction together with a number of exclusion criteria, to avoid pathologizing common behaviours and provide a common ground for further research. The definition and its exclusion criteria are clarified and justified by illustrating how these address a number of theoretical and methodological shortcomings that result from existing conceptualizations. We invite other researchers to extend our definition under an Open Science Foundation framework. [less ▲]

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See detailEuropeans and Americans in Korea, 1882-1910: A Bourgeois and Translocal Community
Dittrich, Klaus UL

in Itinerario (in press), 39(3),

This article deals with the European and American community in Korea between the conclusion of Korea’s first international treaties in the early 1880s and the country’s annexation by the Japanese Empire ... [more ▼]

This article deals with the European and American community in Korea between the conclusion of Korea’s first international treaties in the early 1880s and the country’s annexation by the Japanese Empire in 1910. The article starts out by presenting an overview of the community. Concentrated in Seoul and Chemulp’o, the Anglo-Saxon element dominated a community made up of diplomats, foreign experts in the service of the Korean government, merchants and missionaries. Next, the article describes two key characteristics of the European and American residents in Korea. Firstly, they were individuals defining themselves as bourgeois, or middle-class; secondly, the term “translocality” serves to bring together the multiple layers of border-crossing these individuals were involved in – as long-distance migrants between Europe or Northern America and East Asia, as migrants within the East Asian context, and as representatives of different Euro-American nationalities living together in Korea. [less ▲]

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See detailThe Asymmetry of Counterfactual Dependence
Loew, Christian UL

in Philosophy of Science (in press)

A certain type of counterfactual is thought to be intimately related to causation, control, and explanation. The time asymmetry of these phenomena therefore plausibly arises from a time asymmetry of ... [more ▼]

A certain type of counterfactual is thought to be intimately related to causation, control, and explanation. The time asymmetry of these phenomena therefore plausibly arises from a time asymmetry of counterfactual dependence. But why is counterfactual dependence time asymmetric? The most influential account of the time asymmetry of counterfactual dependence is David Albert’s account, which posits a new, time-asymmetric fundamental physical law, the so-called “past hypothesis.” Albert argues that the time asymmetry of counterfactual dependence arises from holding fixed the past hypothesis when evaluating counterfactuals. In this paper, I argue that Albert’s account misconstrues the time asymmetry of counterfactual dependence. [less ▲]

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See detail'Rationale Trennung' or 'Marriage d'Amour'? History and Philosophy of Educational Research
Priem, Karin UL; Fendler, Lynn

in Espacio, Tiempo y Educacion (in press)

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See detailUniversity competition and transnational education: the choice of branch campus
Tampieri, Alessandro UL; Poyago-Theotoky, Joanna

in B.E. Journal of Theoretical Economics (in press)

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See detailModeling heterogeneity in the pluripotent state: A promising strategy for improving the efficiency and fidelity of stem cell differentiation
Espinosa Angarica, Vladimir UL; del Sol Mesa, Antonio UL

in BioEssays (in press), 38(8),

Pluripotency can be considered a functional characteristic of pluripotent stem cells (PSCs) populations and their niches, rather than a property of individual cells. In this view, individual cells within ... [more ▼]

Pluripotency can be considered a functional characteristic of pluripotent stem cells (PSCs) populations and their niches, rather than a property of individual cells. In this view, individual cells within the population independently adopt a variety of different expression states, maintained by different signaling, transcriptional, and epigenetics regulatory networks. In this review, we propose that generation of integrative network models from single cell data will be essential for getting a better understanding of the regulation of self-renewal and differentiation. In particular, we suggest that the identification of network stability determinants in these integrative models will provide important insights into the mechanisms mediating the transduction of signals from the niche, and how these signals can trigger differentiation. In this regard, the differential use of these stability determinants in subpopulation-specific regulatory networks would mediate differentiation into different cell fates. We suggest that this approach could offer a promising avenue for the development of novel strategies for increasing the efficiency and fidelity of differentiation, which could have a strong impact on regenerative medicine [less ▲]

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See detaile3-service: an ontology for needs-driven real-world service bundling in a multi-supplier setting
De Kinderen, Sybren UL; de Leenheer, Pieter; Gordijn, Jaap et al

in Applied Ontology (in press)

Businesses increasingly offer their services electronically via the Web. Take for example an Internet Service Provider. An ISP offers a variety of services, including raw bandwidth, IP connectivity, and ... [more ▼]

Businesses increasingly offer their services electronically via the Web. Take for example an Internet Service Provider. An ISP offers a variety of services, including raw bandwidth, IP connectivity, and Domain Name resolution. Although in some cases a single service already satisfies a customer need, in many situations a customer need is so complex that a bundle of services is needed to satisfy the need, as with the ISP example. In principle, each service in a bundle can be provisioned by a different supplier. This paper proposes an ontology, e3service , that can be used to formally capture customer needs, services, and multisupplier service bundles of these. In addition, this paper contributes a process called PCM2 to reason with the ontology. First, a customer need is identified for which desired consequences are elicited. Then, the desired set of consequences is matched with consequences associated with services. The matching process results in a service bundle, satisfying the customer need, containing services that each can be provided by different suppliers. PCM2 is inspired by a family of formal reasoning methods called Propose-Critique-Modify (PCM). However, whereas PCM methods emphasize solution generation from a given set of requirements, our reasoning process treats the space of requirements as a first class citizen. Hence PCM2 : the requirements space and solution space are equally important. How the reasoning and matching process practically works, is illustrated by an industry strength case study in the healthcare domain. [less ▲]

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See detailConfiguring use case models in product families
Hajri, Ines UL; Göknil, Arda UL; Briand, Lionel UL et al

in Software & Systems Modeling (in press)

In many domains such as automotive and avionics, the size and complexity of software systems is quickly increasing. At the same time, many stakeholders tend to be involved in the development of such ... [more ▼]

In many domains such as automotive and avionics, the size and complexity of software systems is quickly increasing. At the same time, many stakeholders tend to be involved in the development of such systems, which typically must also be configured for multiple customers with varying needs. Product Line Engineering (PLE) is therefore an inevitable practice for such systems. Furthermore, because in many areas requirements must be explicit and traceability to them is required by standards, use cases and domain models are common practice for requirements elicitation and analysis. In this paper, based on the above observations, we aim at supporting PLE in the context of use case-centric development. Therefore, we propose, apply, and assess a use case-driven configuration approach which interactively receives configuration decisions from the analysts to generate Product Specific (PS) use case and domain models. Our approach provides the following: (1) a use case-centric product line modeling method (PUM), (2) automated, interactive configuration support based on PUM, and (3) an automatic generation of PS use case and domain models from Product Line (PL) models and configuration decisions. The approach is supported by a tool relying on Natural Language Processing (NLP), and integrated with an industrial requirements management tool, i.e., IBM Doors. We successfully applied and evaluated our approach to an industrial case study in the automotive domain, thus showing evidence that the approach is practical and beneficial to capture variability at the appropriate level of granularity and to configure PS use case and domain models in industrial settings. [less ▲]

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See detailA classification of polynomial functions satisfying the Jacobi identity over integral domains
Marichal, Jean-Luc UL; Mathonet, Pierre

in Aequationes Mathematicae (in press)

The Jacobi identity is one of the properties that are used to define the concept of Lie algebra and in this context is closely related to associativity. In this paper we provide a complete description of ... [more ▼]

The Jacobi identity is one of the properties that are used to define the concept of Lie algebra and in this context is closely related to associativity. In this paper we provide a complete description of all bivariate polynomials that satisfy the Jacobi identity over infinite integral domains. Although this description depends on the characteristic of the domain, it turns out that all these polynomials are of degree at most one in each indeterminate. [less ▲]

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See detailQuantization of Poisson manifolds from the integrability of the modular function
Qiu, Jian UL

in Communications in Mathematical Physics (in press)

We discuss a framework for quantizing a Poisson manifold via the quantization of its symplectic groupoid, that combines the tools of geometric quantization with the results of Renault's theory of groupoid ... [more ▼]

We discuss a framework for quantizing a Poisson manifold via the quantization of its symplectic groupoid, that combines the tools of geometric quantization with the results of Renault's theory of groupoid C*-algebras. This setting allows very singular polarizations. In particular we consider the case when the modular function is "multiplicatively integrable", i.e. when the space of leaves of the polarization inherits a groupoid structure. If suitable regularity conditions are satisfied, then one can define the quantum algebra as the convolution algebra of the subgroupoid of leaves satisfying the Bohr-Sommerfeld conditions. We apply this procedure to the case of a family of Poisson structures on CP_n, seen as Poisson homogeneous spaces of the standard Poisson-Lie group SU(n+1). We show that a bihamiltoniam system on CP_n defines a multiplicative integrable model on the symplectic groupoid; we compute the Bohr-Sommerfeld groupoid and show that it satisfies the needed properties for applying Renault theory. We recover and extend Sheu's description of quantum homogeneous spaces as groupoid C*-algebras. [less ▲]

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See detailOn the singular sheaves in the fine Simpson moduli spaces of 1-dimensional sheaves supported on plane quartics
Iena, Oleksandr UL

in Rendiconti dell'Istituto di Matematica dell'Università di Trieste (in press)

In the case of the fine Simpson moduli spaces of 1-dimensional sheaves supported on plane quartics, the subvariety of sheaves that are not locally free on their support is connected, singular, and has ... [more ▼]

In the case of the fine Simpson moduli spaces of 1-dimensional sheaves supported on plane quartics, the subvariety of sheaves that are not locally free on their support is connected, singular, and has codimension 2. [less ▲]

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See detailSpatial discretization error in Kalman filtering for discrete-time infinite dimensional systems
Aalto, Atte UL

in IMA Journal of Mathematical Control and Information (in press)

We derive a reduced-order state estimator for discrete-time infinite dimensional linear systems with finite dimensional Gaussian input and output noise. This state estimator is the optimal one-step ... [more ▼]

We derive a reduced-order state estimator for discrete-time infinite dimensional linear systems with finite dimensional Gaussian input and output noise. This state estimator is the optimal one-step estimate that takes values in a fixed finite dimensional subspace of the system’s state space — consider, for example, a Finite Element space. The structure of the obtained state estimator is like the Kalman filter, but with an additional optimal embedding operator mapping from the reduced space to the original state space. We derive a Riccati difference equation for the error covariance and use sensitivity analysis to obtain a bound for the error of the state estimate due to the state space discretization. [less ▲]

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See detailInterindividual differences in responses to global inequality
Reese, Gerhard UL; Proch, Jutta; Cohrs, J. Christopher

in Analyses of Social Issues and Public Policy (in press)

One of humanity’s most pressing problems is the inequality between people from “developed” and “developing” countries, which counteracts joint efforts to combat other large scale problems. Little is known ... [more ▼]

One of humanity’s most pressing problems is the inequality between people from “developed” and “developing” countries, which counteracts joint efforts to combat other large scale problems. Little is known about the psychological antecedents that affect the perception of and behavioral responses to global inequality. Based on, and extending, Duckitt’s (2001) dual-process model, the current research examines psychological antecedents that may explain how people in an industrialized Western country respond to global inequality. In two studies (N1 = 116, N2 = 117), we analyzed the relationship between the Big Five and justice constructs, right-wing authoritarianism (RWA), social dominance orientation (SDO), and behavioral intentions to reduce global inequality. Two-group path analysis revealed support for the dual-process model in that RWA and SDO were important predictors of behavioral intentions and partially acted as mediators between personality and such intentions. Moreover, justice sensitivity explained variance beyond the “classic” DPM variables. In Study 2, we additionally assessed individuals’ global social identification and perceived injustice of global inequality that explained additional variance. Extending previous work on the dual-process model, these findings demonstrate that individual and group-based processes predict people’s responses to global inequality and uncover potentials to promote behavior in the interest of global justice. [less ▲]

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See detailAging and Time Perception for Short and Long Durations: A Question of Attention?
Lamotte, Mathilde UL; Droit-Volet, Sylvie

in Timing & Time Perception (in press)

This study examined the difference in the perception of time between young and older adults in a temporal bisection task with four different duration ranges from a few milliseconds (500 ms) to several ... [more ▼]

This study examined the difference in the perception of time between young and older adults in a temporal bisection task with four different duration ranges from a few milliseconds (500 ms) to several seconds (30 s). In addition, individual cognitive capacities (short-term memory, working memory, processing speed, attention) were assessed with different neuropsychological tests. The results showed a general effect of age on the variability of time judgment, indicating a lower sensitivity to time in the old than in the younger adults, regardless of the duration range tested. In addition, the results showed that the individual differences in time sensitivity were explained by attention capacities, which decline with aging. [less ▲]

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See detailMeasuring urban forms from inter-building distances: Combining MST graphs with a Local Index of Spatial Association
Caruso, Geoffrey UL; Hilal, Mohamed; Thomas, Isabelle

in Landscape & Urban Planning (2017), 163

A new method is proposed for characterising local urban patterns at the scale of a large urban region. The approach overcomes the difficulties of surface-based representations of built-up morphologies and ... [more ▼]

A new method is proposed for characterising local urban patterns at the scale of a large urban region. The approach overcomes the difficulties of surface-based representations of built-up morphologies and provides an efficient way to account for the proximity of built and non-built land. The strength of the approach resides in the direct use of the coordinates of each building, a very parsimonious input of external parameters, and a local spatial statistical perspective. The method consists in, first, constructing and clumping the Minimum Spanning Tree (MST) that links each building to its neighbours in order to obtain connected urban and suburban graph subsets, and second, measuring a Local Index of Spatial Association (LISA) on inter-building distances in order to characterise patterns. The method differentiates heterogeneous settlements from statistically significant homogeneous clusters with either long or short connections between buildings. The method is applied to the Southern periphery of Brussels (Belgium). [less ▲]

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See detailIDENTITY AND ITS CONSTRUAL: LEARNING FROM LUXEMBOURG
Murdock, Elke UL

in Integrative Psychological & Behavioral Science (2017)

This article examines national identity construal processes within the case study context of Luxembourg. Building on research highlighting the modalities of generalization from case studies, I present the ... [more ▼]

This article examines national identity construal processes within the case study context of Luxembourg. Building on research highlighting the modalities of generalization from case studies, I present the country case that is Luxembourg. This social universe has a foreign population percentage of 47% and what is considered majority and minority becomes increasingly fluid. The migration process itself is fluid, ranging from daily migration, to medium-term stays, return visits and permanent immigration including uptake of citizenship. Within such a fluid environment, where national borders are permeable at the physical level of crossing borders and (national) societies are nested within societies, culture contact is a permanent feature in daily life. Nationality becomes a salient feature as culture contact tends to prompt reflection, resulting in questioning and (re-)negotiation of national identity. This affects the native population as well as the diverse immigrant population – with diversity going beyond the level of country of origin. Many individuals are also of mixed nationality and some examples for the construal process of national identity will be provided, illustrating how national identity is negotiated at individual level. Like a periscope, this country let s us adjust mirrors, permitting us to observe modes of identity construal which would otherwise be obstructed from the field of view. The case study that is Luxembourg allows us to look at the micro-setting of the construction, potentially of something new. [less ▲]

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See detailAccelerating Monte Carlo estimation with derivatives of high-level finite element models
Hauseux, Paul UL; Hale, Jack UL; Bordas, Stéphane UL

in Computer Methods in Applied Mechanics & Engineering (2017), 318

In this paper we demonstrate the ability of a derivative-driven Monte Carlo estimator to accelerate the propagation of uncertainty through two high-level non-linear finite element models. The use of ... [more ▼]

In this paper we demonstrate the ability of a derivative-driven Monte Carlo estimator to accelerate the propagation of uncertainty through two high-level non-linear finite element models. The use of derivative information amounts to a correction to the standard Monte Carlo estimation procedure that reduces the variance under certain conditions. We express the finite element models in variational form using the high-level Unified Form Language (UFL). We derive the tangent linear model automatically from this high-level description and use it to efficiently calculate the required derivative information. To study the effectiveness of the derivative-driven method we consider two stochastic PDEs; a one- dimensional Burgers equation with stochastic viscosity and a three-dimensional geometrically non-linear Mooney-Rivlin hyperelastic equation with stochastic density and volumetric material parameter. Our results show that for these problems the first-order derivative-driven Monte Carlo method is around one order of magnitude faster than the standard Monte Carlo method and at the cost of only one extra tangent linear solution per estimation problem. We find similar trends when comparing with a modern non-intrusive multi-level polynomial chaos expansion method. We parallelise the task of the repeated forward model evaluations across a cluster using the ipyparallel and mpi4py software tools. A complete working example showing the solution of the stochastic viscous Burgers equation is included as supplementary material. [less ▲]

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See detailShape-aware surface reconstruction from sparse 3D point-clouds
Bernard, Florian UL; Salamanca Mino, Luis UL; Thunberg, Johan UL et al

in Medical Image Analysis (2017), 38

The reconstruction of an object’s shape or surface from a set of 3D points plays an important role in medical image analysis, e.g. in anatomy reconstruction from tomographic measurements or in the process ... [more ▼]

The reconstruction of an object’s shape or surface from a set of 3D points plays an important role in medical image analysis, e.g. in anatomy reconstruction from tomographic measurements or in the process of aligning intra-operative navigation and preoperative planning data. In such scenarios, one usually has to deal with sparse data, which significantly aggravates the problem of reconstruction. However, medical applications often provide contextual information about the 3D point data that allow to incorporate prior knowledge about the shape that is to be reconstructed. To this end, we propose the use of a statistical shape model (SSM) as a prior for surface reconstruction. The SSM is represented by a point distribution model (PDM), which is associated with a surface mesh. Using the shape distribution that is modelled by the PDM, we formulate the problem of surface reconstruction from a probabilistic perspective based on a Gaussian Mixture Model (GMM). In order to do so, the given points are interpreted as samples of the GMM. By using mixture components with anisotropic covariances that are “oriented” according to the surface normals at the PDM points, a surface-based fitting is accomplished. Estimating the parameters of the GMM in a maximum a posteriori manner yields the reconstruction of the surface from the given data points. We compare our method to the extensively used Iterative Closest Points method on several different anatomical datasets/SSMs (brain, femur, tibia, hip, liver) and demonstrate superior accuracy and robustness on sparse data. [less ▲]

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See detailEconomic Downturns, Retirement and Long-Term Cognitive Function Among Older Americans
Hessel, Philipp; Riumallo-Herl, Carlos; Leist, Anja UL et al

in Journals of Gerontology Series B : Psychological Sciences & Social Sciences (2017)

Objective: Workers approaching retirement may be particularly vulnerable to economic downturns. This study assesses whether exposure to economic downturns around retirement age leads to poorer cognitive ... [more ▼]

Objective: Workers approaching retirement may be particularly vulnerable to economic downturns. This study assesses whether exposure to economic downturns around retirement age leads to poorer cognitive function in later life. Method: Longitudinal data for 13,577 individuals in the Health and Retirement Study were linked to unemployment rates in state of residence. Random- and fixed-effect models were used to examine whether downturns at 55–64 years of age were associated with cognitive functioning levels and decline at ≥65 years, measured by the Wechsler Adult Intelligence Scale-Revised. Results: Longer exposure to downturns at 55–64 years of age was associated with lower levels of cognitive function at ≥65 years. Compared to individuals experiencing only up to 1 year in a downturn at 55–64 years of age, individuals experiencing two downturns at these ages had 0.09 point (95% Confidence Interval [CI, −0.17, −0.02]) lower cognitive functioning scores at ≥65 years (3 years: b = −0.17, 95%CI [−0.29, −0.06]; 4 years: b = −0.14, 95%CI [−0.25, −0.02]; ≥5 years: b = −0.22, 95%CI [−0.38, −0.06]). Downturns at 55–64 years of age were not associated with rates of cognitive decline. Discussion: Exposure to downturns around retirement is associated with a long-lasting decline in cognitive function in later life. Policies mitigating the impact of downturns on older workers may help to maintain cognitive function in later life. [less ▲]

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See detailBiallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features
Santiago-Sim, Teresa; Burrage, Lindsay C.; Ebstein, Frederic et al

in American Journal of Human Genetics (2017), 100(4), 676-688

Ubiquitination is a posttranslational modification that regulates many cellular processes including protein degradation, intracellular trafficking, cell signaling, and protein-protein interactions ... [more ▼]

Ubiquitination is a posttranslational modification that regulates many cellular processes including protein degradation, intracellular trafficking, cell signaling, and protein-protein interactions. Deubiquitinating enzymes (DUBs), which reverse the process of ubiquitination, are important regulators of the ubiquitin system. OTUD6B encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Herein, we report biallelic pathogenic variants in OTUD6B in 12 individuals from 6 independent families with an intellectual disability syndrome associated with seizures and dysmorphic features. In subjects with predicted loss-of-function alleles, additional features include global developmental delay, microcephaly, absent speech, hypotonia, growth retardation with prenatal onset, feeding difficulties, structural brain abnormalities, congenital malformations including congenital heart disease, and musculoskeletal features. Homozygous Otud6b knockout mice were subviable, smaller in size, and had congenital heart defects, consistent with the severity of loss-of-function variants in humans. Analysis of peripheral blood mononuclear cells from an affected subject showed reduced incorporation of 19S subunits into 26S proteasomes, decreased chymotrypsin-like activity, and accumulation of ubiquitin-protein conjugates. Our findings suggest a role for OTUD6B in proteasome function, establish that defective OTUD6B function underlies a multisystemic human disorder, and provide additional evidence for the emerging relationship between the ubiquitin system and human disease. [less ▲]

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See detailSocial inequalities in dementia care, cure, and research
Leist, Anja UL

in Journal of the American Geriatrics Society (2017)

Social inequalities in dementia can be found in diagnosis, cure, care, and research. Less advantaged groups are women, persons with ethnic minority status, lower income, lower education, and living in ... [more ▼]

Social inequalities in dementia can be found in diagnosis, cure, care, and research. Less advantaged groups are women, persons with ethnic minority status, lower income, lower education, and living in more deprived or rural areas. These social inequalities suggest that funding of research and medical and care expenses related to dementia may not be equitably allocated to those in need, even in the most advanced countries. Experience from the field of heart disease gives an estimate on the timescale and efforts it takes to successfully address social inequalities related to gender. Strong concerted efforts will be needed to mitigate social inequalities in dementia. [less ▲]

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