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See detailTreg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarshi, Koji; Tanoue, Takeshi; Oshima, Kenshiro et al

in Nature (2013), 500

Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases1, 2. Although numerous probiotic microorganisms have been identified3, there remains a ... [more ▼]

Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases1, 2. Although numerous probiotic microorganisms have been identified3, there remains a compelling need to discover organisms that elicit more robust therapeutic responses, are compatible with the host, and can affect a specific arm of the host immune system in a well-controlled, physiological manner. Here we use a rational approach to isolate CD4+FOXP3+ regulatory T (Treg)-cell-inducing bacterial strains from the human indigenous microbiota. Starting with a healthy human faecal sample, a sequence of selection steps was applied to obtain mice colonized with human microbiota enriched in Treg-cell-inducing species. From these mice, we isolated and selected 17 strains of bacteria on the basis of their high potency in enhancing Treg cell abundance and inducing important anti-inflammatory molecules—including interleukin-10 (IL-) and inducible T-cell co-stimulator (ICOS)—in Treg cells upon inoculation into germ-free mice. Genome sequencing revealed that the 17 strains fall within clusters IV, XIVa and XVIII of Clostridia, which lack prominent toxins and virulence factors. The 17 strains act as a community to provide bacterial antigens and a TGF-β-rich environment to help expansion and differentiation of Treg cells. Oral administration of the combination of 17 strains to adult mice attenuated disease in models of colitis and allergic diarrhoea. Use of the isolated strains may allow for tailored therapeutic manipulation of human immune disorders. [less ▲]

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See detailTREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study
Ortega-Cubero, S.; Lorenzo-Betancor, O.; Lorenzo, E. et al

in Parkinsonism & related disorders (2015), 21(3), 306-309

INTRODUCTION: Essential tremor (ET) is the most frequent movement disorder in adults. Its pathophysiology is not clearly understood, however there is growing evidence showing common etiologic factors with ... [more ▼]

INTRODUCTION: Essential tremor (ET) is the most frequent movement disorder in adults. Its pathophysiology is not clearly understood, however there is growing evidence showing common etiologic factors with other neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (AD, PD). Recently, a rare p.R47H substitution (rs75932628) in the TREM2 protein (triggering receptor expressed on myeloid cells 2; OMIM: *605086) has been proposed as a risk factor for AD, PD and amyotrophic lateral sclerosis (ALS). The objective of the study was to determine whether TREM2 p.R47H allele is also a risk factor for developing ET. METHODS: This was a cross-sectional multicenter international study. An initial case-control cohort from Spain (n = 456 ET, n = 2715 controls) was genotyped. In a replication phase, a case-control series (n = 897 ET, n = 1449 controls) from different populations (Italy, Germany, North-America and Taiwan) was studied. Owed to the rarity of the variant, published results on p.R47H allele frequency from 14777 healthy controls from European, North American or Chinese descent were additionally considered. The main outcome measure was p.R47H (rs75932628) allelic frequency. RESULTS: There was a significant association between TREM2 p.R47H variant and ET in the Spanish cohort (odds ratio [OR], 5.97; 95% CI, 1.203-29.626; p = 0.042), but it was not replicated in other populations. CONCLUSIONS: These results argue in favor of population-specific differences in the allelic distribution and suggest that p.R47H (rs75932628) variant may contribute to the susceptibility of ET in Spanish population. However, taking into account the very low frequency of p.R47H, further confirmatory analyses of larger ET series are needed. [less ▲]

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See detailTREM2 triggers microglial density and age‐related neuronal loss
Linnartz-Gerlach, Bettina; Bodea, Liviu-Gabriel; Klaus, Christine et al

in Glia (2018)

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to ... [more ▼]

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with aging. The typical aging process goes along with microglial changes and mild neuronal loss, but the exact contribution of TREM2 is still unclear. Aged TREM2 knock‐out mice showed decreased age‐related neuronal loss in the substantia nigra and the hippocampus. Transcriptomic analysis of the brains of 24 months old TREM2 knock‐out mice revealed 211 differentially expressed genes mostly downregulated and associated with complement activation and oxidative stress response pathways. Consistently, 24 months old TREM2 knock‐out mice showed lower transcription of microglial (Aif1 and Tmem119), oxidative stress markers (Inos, Cyba, and Cybb) and complement components (C1qa, C1qb, C1qc, C3, C4b, Itgam, and Itgb2), decreased microglial numbers and expression of the microglial activation marker Cd68, as well as accumulation of oxidized lipids. Cultured microglia of TREM2 knock‐out mice showed reduced phagocytosis and oxidative burst. Thus, microglial TREM2 contributes to age‐related microglial changes, phagocytic oxidative burst, and loss of neurons with possible detrimental effects during physiological aging. [less ▲]

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See detailtrend Analysis and interpretation of Luxembourg’s consumption Footprint NFA 2010 edition, data years 2000 – 2007
Hild, Paula UL; Takagi, Aya; Schmitt, Bianca

Report (2012)

The Ecological Footprint methodology by Global Footprint Network measures human consumption of products and services from different ecosystems in terms of the amount of bioproductive land and sea area ... [more ▼]

The Ecological Footprint methodology by Global Footprint Network measures human consumption of products and services from different ecosystems in terms of the amount of bioproductive land and sea area needed to supply these products and services. In other words, the Ecological Footprint calculates the land area needed to produce food, provide resources, produce energy, and absorb the CO2 emissions generated by the supply chains within one year at country level. For the calculations of Luxembourg’s Ecological Footprint, international statistical databases are used to identify the quantities of produced, imported and exported goods and services. Then, Global Footprint Network applies different factors to the quantities to assess the area needed to supply these products and services. Finally, the Consumption Footprint of a nation is divided by the number of inhabitants and compared to other countries at a per capita level (global hectares per capita). This means that the Ecological Footprint can be used as an indicator for the sustainability of a national consumption by assessing human land uses. In the following paragraph, Luxembourg’s Ecological Footprint is discussed in the framework of the environmental indicators of Luxembourg’s competitiveness scoreboard (see Table 9) [MECE, 2010]. Luxembourg’s ranking is rather low for all of the scoreboard indicators: number of ISO 9001 certifications per billion of inhabitants (21 out of 27); number of ISO 14001 certifications per billion of inhabitants (15 out of 27); total greenhouse gas emissions (15 out of 27); renewable energy ration (23 out of 27); quantity of municipal waste per capita per year (24 out of 27); energetic intensity (8 out of 27); transport by car (17 out of 27); Ecological Footprint in gha per capita per year (27 out of 27). Based on the environmental competiveness scoreboard indicators, it can be concluded that in general, Luxembourg’s environmental performance is low compared to the other countries of the European Union. With respect to Luxembourg’s Ecological Footprint, it can be said that Luxembourg’s consumption is not sustainable. The number of planets that would be needed if the world's population lived like the population of Luxembourg in 2007 is about six. However, per year, the biocapacity (bioproductive land) of the planet can only regenerate once. [less ▲]

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See detailTrends and Players in Tax Policy: Greece
Pantazatou, Aikaterini UL

in M. Lang et al. (Ed.) Trends and Players in Tax Policy (2016)

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See detailTrends and Players in tax policy: Greece
Pantazatou, Aikaterini UL

Presentation (2013, July)

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See detailTrends and transitions
Vögele, Claus UL

in European Journal of Health Psychology (2018), 25(1), 1

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See detailTrends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase
Patterson, C.C.; Gyürüs, E.; Rosenbauer, J. et al

in Diabetologia (2012), 55(8), 2142-2147

Aims/hypothesis The aim of the study was to describe 20- year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989–1998) and second ... [more ▼]

Aims/hypothesis The aim of the study was to describe 20- year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989–1998) and second (1999–2008) halves of the period. Methods All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture–recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied. Results Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half. Conclusions/interpretation The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3–4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted. [less ▲]

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See detailTrends in Model-based GUI Testing
Arlt, Stephan UL; Bertolini, Cristiano; Pahl, Simon et al

in Advances in Computers (2012), 86

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See detailTrends in Rainfall and Economic Growth In Africa: A Neglected Cause of the African Growth Tragedy
Barrios, Salvador; Bertinelli, Luisito UL; Strobl, Eric

in Review of Economics and Statistics (2010), 92(2), 350-366

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See detailTrends in Service Delivery: Psychological Practice in Rehabilitation Settings
Pit-Ten Cate, Ineke UL; Padrone, F; Feinblatt, A et al

Scientific Conference (1995, August)

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See detailTrends in service delivery: Psychological practice in rehabilitation settings
Pit-Ten Cate, Ineke UL; Padrone, Frank; Feinblatt, Arlene et al

in Rehabilitation Outllook (1997)

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See detailTrends in the incidence of childhood onset diabetes in Europe. 1989-1998
Green, A.; Patterson, C.C.; De Beaufort, Carine UL

in Diabetologia (2001), 44(3), 3-8

AIMS/HYPOTHESIS: To study the epidemiology of childhood-onset (Type I) insulin-dependent diabetes mellitus in Europe, the EURODIAB collaborative group in 1988 established prospective, geographically ... [more ▼]

AIMS/HYPOTHESIS: To study the epidemiology of childhood-onset (Type I) insulin-dependent diabetes mellitus in Europe, the EURODIAB collaborative group in 1988 established prospective, geographically-defined registers of all children diagnosed with Type I diabetes under 15 years of age. This report is based on 24,423 children, registered by 36 centres, with complete participation during the period 1989-1998 and representing most European countries with a population coverage of approximately 20 million children. METHODS: Multiple sources of ascertainment were used to validate the level of ascertainment. Trends in Type I diabetes incidence during the period were analysed using Poisson regression with the results from the 36 centres pooled into nine regions. RESULTS: The standardised average annual incidence rate of Type I diabetes varied more than tenfold between centres. Overall, the annual increase in incidence was 3.2% (95%-CI: 2.7%, 3.7%), being highest for children in the 0-4-year age-group 4.8% (3.8%, 5.9%) and lowest for children in the 10-14-year age group 2.1 % (1.4%, 2.8%). However, the absolute increases in Type I diabetes were roughly similar in the three age-groups of 0-4, 5-9 and 10-14 years. Central Eastern Europe showed the highest increase whereas Sardinia and Northern Europe (except Finland) showed no evidence of an increase. For all age-groups relatively fewer cases had disease onset during the summer months, especially the 10-14-year age-group. CONCLUSION/INTERPRETATION: The extremely large range of incidence rates within Europe has been confirmed. The incidence rate is generally increasing but is more pronounced in some regions than in others. Seasonality at disease onset is apparent even in the youngest age-group. [less ▲]

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See detailTrends in UK Mean Sea Level revisited
Woodworth, P.; Teferle, Felix Norman UL; Bingley, R. M. et al

in Geophysical Journal International (2009), 179(179), 19-30

This paper presents estimates of rates of mean sea level (MSL) change around the UK based on a larger tide gauge data set and more accurate analysis methods than have been employed so far. The spatial ... [more ▼]

This paper presents estimates of rates of mean sea level (MSL) change around the UK based on a larger tide gauge data set and more accurate analysis methods than have been employed so far. The spatial variation of the trend in MSL is found to be similar to that inferred from geological information and from advanced geodetic techniques, which is a similar conclusion to that arrived at in previous, less precise and complete studies. The tide gauge MSL trends for 1901 onwards are estimated to be 1.4 +/- 0.2 mm/year larger than those inferred from geology or geodetic methods, suggesting a regional sea level rise of climate change origin several 1/10s mm/year lower than global estimates for the 20th century. However, UK MSL change cannot be described in terms of a simple linear increase alone but includes variations on interannual and decadal timescales. The possible sources of variation in a ‘UK sea level index’ are explored. Air pressure is clearly one such possible source but its direct local forcing through the ‘inverse barometer’ accounts for only one third of the observed variability. A number of larger scale atmospheric and ocean processes must also play important roles, but modelling them satisfactorily and separating the individual contributions presents a major challenge. As regards future regional UK sea level changes, one concludes that there is no basis for major modification to existing projections for the 2080s included in the 2002 UK Climate Impacts Programme studies. [less ▲]

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See detailDie Treuhand:aktuelle Entwicklung in den Civil law-Staaten und Libanon
Prüm, André UL; Witz, Claude

in Zeitschrift für Europäisches Privatrecht (2006)

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See detailLes Trévires vus par le jésuite luxembourgeois Alexandre Wiltheim
Binsfeld, Andrea UL

in Hébert, Oriane; Pechoux, Ludivine (Eds.) Quand l’usage fait l’image. Les Gaulois, de la manipulation historique à l’archétype (2017)

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See detailThe Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up.
Akerblom, H.K.; Krischer, J; Virtanen, SM et al

in Diabetologia (2011), 54(3), 627-633

AIMS/HYPOTHESIS: The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study was designed to establish whether weaning to a highly hydrolysed formula in infancy subsequently reduces the risk of type ... [more ▼]

AIMS/HYPOTHESIS: The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study was designed to establish whether weaning to a highly hydrolysed formula in infancy subsequently reduces the risk of type 1 diabetes. METHODS: The study population comprises newborn infants who have first-degree relatives with type 1 diabetes and meet the increased risk HLA inclusion, but not exclusion criteria. The study is being performed in 15 countries in three continents. First-degree relatives of patients with type 1 diabetes were identified from diabetes clinics, diabetes registries, and from other endocrinology or obstetrics offices and websites. HLA typing was performed at birth from cord or heel stick blood, and the results sent to the study's Data Management Unit within 2 weeks for communication of eligibility to the clinical study centre. All mothers recruited were encouraged to breastfeed. The intervention lasted for 6 to 8 months, and weaning formulas based on hydrolysed casein and standard cow's milk were compared. RESULTS: TRIGR recruited 5,606 infants, of whom 2,160 were enrolled as eligible participants, 6% more than the target of 2,032. Of those enrolled, 80% were exposed to the study formula. The overall retention rate over the first 5 years is 87%, with protocol compliance at 94%. The randomisation code will be opened when the last recruited child turns 10 years of age, i.e. in 2017. CONCLUSIONS/INTERPRETATION: The TRIGR experience demonstrates the feasibility and successful implementation of an international dietary intervention study. TRIGR is the first ever primary prevention trial for type 1 diabetes and, if completed successfully, will provide a definite answer to the research question. TRIAL REGISTRATION: ClinicalTrials.gov NCT00179777 FUNDING: The study was funded by the National Institute of Child Health and Development (NICHD) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH) (grant numbers HD040364, HD042444 and HD051997), Canadian Institutes of Health Research, the Juvenile Diabetes Research Foundation International and the Commission of the European Communities (specific RTD programme 'Quality of Life and Management of Living Resources', contract number QLK1-2002-00372 'Diabetes Prevention'. Other funding came from the EFSD/JDRF/Novo Nordisk Focused Research Grant, Academy of Finland, Dutch Diabetes Research Foundation and Finnish Diabetes Research Foundation). [less ▲]

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See detailTriathlon of Lightweight Block Ciphers for the Internet of Things
Dinu, Dumitru-Daniel UL; Le Corre, Yann UL; Khovratovich, Dmitry UL et al

in Journal of Cryptographic Engineering (2018)

In this paper, we introduce a framework for the benchmarking of lightweight block ciphers on a multitude of embedded platforms. Our framework is able to evaluate the execution time, RAM footprint, as well ... [more ▼]

In this paper, we introduce a framework for the benchmarking of lightweight block ciphers on a multitude of embedded platforms. Our framework is able to evaluate the execution time, RAM footprint, as well as binary code size, and allows one to define a custom "figure of merit" according to which all evaluated candidates can be ranked. We used the framework to benchmark implementations of 19 lightweight ciphers, namely AES, Chaskey, Fantomas, HIGHT, LBlock, LEA, LED, Piccolo, PRESENT, PRIDE, PRINCE, RC5, RECTANGLE, RoadRunneR, Robin, Simon, SPARX, Speck, and TWINE, on three microcontroller platforms: 8-bit AVR, 16-bit MSP430, and 32-bit ARM. Our results bring some new insights into the question of how well these lightweight ciphers are suited to secure the Internet of things. The benchmarking framework provides cipher designers with an easy-to-use tool to compare new algorithms with the state of the art and allows standardization organizations to conduct a fair and consistent evaluation of a large number of candidates. [less ▲]

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See detailTriathlon of Lightweight Block Ciphers for the Internet of Things
Dinu, Dumitru-Daniel UL; Le Corre, Yann UL; Khovratovich, Dmitry UL et al

Scientific Conference (2015, July)

In this paper we introduce an open framework for the benchmarking of lightweight block ciphers on a multitude of embedded platforms. Our framework is able to evaluate execution time, RAM footprint, as ... [more ▼]

In this paper we introduce an open framework for the benchmarking of lightweight block ciphers on a multitude of embedded platforms. Our framework is able to evaluate execution time, RAM footprint, as well as (binary) code size, and allows a user to define a custom "figure of merit" according to which all evaluated candidates can be ranked. We used the framework to benchmark various implementations of 13 lightweight ciphers, namely AES, Fantomas, HIGHT, LBlock, LED, Piccolo, PRESENT, PRINCE, RC5, Robin, Simon, Speck, and TWINE, on three different platforms: 8-bit ATmega, 16-bit MSP430, and 32-bit ARM. Our results give new insights to the question of how well these ciphers are suited to secure the Internet of Things (IoT). The benchmarking framework provides cipher designers with a tool to compare new algorithms with the state-of-the-art and allows standardization bodies to conduct a fair and comprehensive evaluation of a large number of candidates. [less ▲]

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See detailTriaxiaalproeven op Limburgse mergel leveren verassende resultaten
Pytlik, Robert Stanislaw UL; Van Baars, Stefan UL

in Geotechniek (2015), 3(19), 10-13

De civiele werken van de A2-tunnel in Maastricht zijn onlangs voltooid. Tijdens de bouw werd de Limburgse mergel in de bouwput als een stijve, stevige grondlaag beoordeeld, terwijl het na het verwijderen ... [more ▼]

De civiele werken van de A2-tunnel in Maastricht zijn onlangs voltooid. Tijdens de bouw werd de Limburgse mergel in de bouwput als een stijve, stevige grondlaag beoordeeld, terwijl het na het verwijderen als een cohesieloos zand werd aangezien. Om het sterktegedrag van deze mergel beter te begrijpen is door de Universiteit van Luxemburg aanvullend onderzoek gedaan. Uit triaxiaalproeven blijkt verrassenderwijze dat de sterkteparameters van verkruimelde mergel weinig afwijken van intacte mergel. De toplaag van de mergel heeft een zeer kleine cohesie en een grote hoek van inwendige wrijving. Alhoewel hierdoor de mergel onder druk zeer sterk is, is de mergel vrijwel niet in staat om trek op te nemen. [less ▲]

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