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See detailTranscriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia.
Saumet, Anne; Vetter, Guillaume; Bouttier, Manuella et al

in Blood (2009), 113(2), 412-21

Micro(mi)RNAs are small noncoding RNAs that orchestrate many key aspects of cell physiology and their deregulation is often linked to distinct diseases including cancer. Here, we studied the contribution ... [more ▼]

Micro(mi)RNAs are small noncoding RNAs that orchestrate many key aspects of cell physiology and their deregulation is often linked to distinct diseases including cancer. Here, we studied the contribution of miRNAs in a well-characterized human myeloid leukemia, acute promyelocytic leukemia (APL), targeted by retinoic acid and trioxide arsenic therapy. We identified several miRNAs transcriptionally repressed by the APL-associated PML-RAR oncogene which are released after treatment with all-trans retinoic acid. These coregulated miRNAs were found to control, in a coordinated manner, crucial pathways linked to leukemogenesis, such as HOX proteins and cell adhesion molecules whose expressions are thereby repressed by the chemotherapy. Thus, APL appears linked to transcriptional perturbation of miRNA genes, and clinical protocols able to successfully eradicate cancer cells may do so by restoring miRNA expression. The identification of abnormal miRNA biogenesis in cancer may therefore provide novel biomarkers and therapeutic targets in myeloid leukemias. [less ▲]

Detailed reference viewed: 29 (0 UL)
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See detailTranscriptional variations in the wider peritumoral tissue environment of pancreatic cancer
Kreis, Stephanie UL; Bauer, A; Hoheisel, J

in International Journal of Cancer = Journal International du Cancer (2017)

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See detailTranscriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells
del Sol Mesa, Antonio UL; Mummery, Christine

in Development (2015)

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See detailTranscriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells
W. van den Berg, Cathelijne; Okawa, Satoshi UL; M. Chuva de Sousa Lopes, Susana et al

in Development (2015)

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See detailTranscriptomic analyses of primary astrocytes under TNFα treatment
Birck, Cindy UL; Koncina, Eric UL; Heurtaux, Tony UL et al

in Genomics Data (2016), 7

Astrocytes, the most abundant glial cell population in the central nervous system, have important functional roles in the brain as blood brain barrier maintenance, synaptic transmission or intercellular ... [more ▼]

Astrocytes, the most abundant glial cell population in the central nervous system, have important functional roles in the brain as blood brain barrier maintenance, synaptic transmission or intercellular communications. Numerous studies suggested that astrocytes exhibit a functional and morphological high degree of plasticity. For example, following any brain injury, astrocytes become reactive and hypertrophic. This phenomenon, also called reactive gliosis, is characterized by a set of progressive gene expression and cellular changes. Interestingly, in this context, astrocytes can re-acquire neurogenic properties. It has been shown that astrocytes can undergo dedifferentiation upon injury and inflammation, and may re-acquire the potentiality of neural progenitors. To assess the effect of inflammation on astrocytes, primary mouse astrocytes were treated with tumor necrosis factor α (TNFα), one of the main pro-inflammatory cytokines. The strength of this study is that pure primary astrocytes were used. As microglia are highly reactive immune cells, we used a magnetic cell sorting separation (MACS) method to further obtain highly pure astrocyte cultures devoid of microglia. Here, we provide details of the microarray data, which have been deposited in the Gene Expression Omnibus (GEO) under the series accession number GSE73022. The analysis and interpretation of these data are included in Gabel et al. (2015). Analysis of gene expression indicated that the NFκB pathway-associated genes were induced after a TNFα treatment. We have shown that primary astrocytes devoid of microglia can respond to a TNFα treatment with the re-expression of genes implicated in the glial cell development. [less ▲]

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See detailTranscriptomics profiling of human SGBS adipogenesis
Galhardo, Mafalda Sofia UL; Sinkkonen, Lasse UL; Berninger, Philipp et al

in Genomics Data (2014), 2

Obesity is an ever-growing epidemic where tissue homeostasis is influenced by the differentiation of adipocytes that function in lipid metabolism, endocrine and inflammatory processes. While this ... [more ▼]

Obesity is an ever-growing epidemic where tissue homeostasis is influenced by the differentiation of adipocytes that function in lipid metabolism, endocrine and inflammatory processes. While this differentiation process has been well-characterized in mice, limited data is available from human cells. Applying microarray expression profiling in the human SGBS pre-adipocyte cell line, we identified genes with differential expression during differentiation in combination with constraint-based modeling of metabolic pathway activity. Here we describe the experimental design and quality controls in detail for the gene expression and related results published by Galhardo et al. in Nucleic Acids Research 2014 associated with the data uploaded to NCBI Gene Expression Omnibus (). [less ▲]

Detailed reference viewed: 80 (17 UL)
See detailTranscultural Encounters: De- and Re-humanisation of the Worker in Multinational “Luxembourgish” Poetry, 1900-1940
Millim, Anne-Marie UL

in Glesener, Jeanne, E. (Ed.) Lëtzebuerger Literaturen am Verglach (2016)

Detailed reference viewed: 24 (4 UL)
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See detailTransdisciplinarity or "engaged pluralism"?
Hesse, Markus UL

in DISP Dokumente und Informationen zur Schweizerischen Orts-, Regional- und Landesplanung (2015), 51(3), 4-5

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See detailTransdisziplinäre Alter(n)sstudien. Gegenstände und Methoden
Breinbauer, Ines; Ferring, Dieter UL; Haller, Miriam et al

Book published by Königshausen und Neumann (2010)

Detailed reference viewed: 28 (4 UL)
See detailTransdisziplinäre Alternsstudien als disziplinäre Ko-Konstruktion.
Breinbauer, Ines; Ferring, Dieter UL; Haller, Miriam et al

in Transdisziplinäre Alter(n)sstudien. Gegenstände und Methoden (2010)

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See detailTransdisziplinäre Altersforschung und Partizipation.
Ferring, Dieter UL

in Transdisziplinäre Alter(n)sstudien. Gegenstände und Methoden (2010)

Detailed reference viewed: 35 (2 UL)
See detailTransfer
Hu, Adelheid UL

in Hu, Adelheid; Byram, Michael (Eds.) Routledge Encyclopedia of Language Teaching and Learning (2012)

Detailed reference viewed: 34 (2 UL)
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See detailTransfer matrix analysis of one-dimensional majority cellular automata with thermal noise
Lemoy, Rémi UL; Mozeika, Alexander; Seki, Shinnosuke

in JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL (2014), 47(10), 105001-11

Thermal noise in a cellular automaton (CA) refers to a random perturbation in its function which eventually leads the automaton to an equilibrium state controlled by a temperature parameter. We study the ... [more ▼]

Thermal noise in a cellular automaton (CA) refers to a random perturbation in its function which eventually leads the automaton to an equilibrium state controlled by a temperature parameter. We study the one-dimensional majority-3 CA under this model of noise. Without noise, each cell in the automaton decides its next state by majority voting among itself and its left and right neighbour cells. Transfer matrix analysis shows that the automaton always reaches a state in which every cell is in one of its two states with probability 1/2 and thus cannot remember even one bit of information. Numerical experiments, however, support the possibility of reliable computation for a long but finite time. [less ▲]

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See detailTransfer of Cultural Capital: A Comparative Analysis of the Interconnection of Well-Being, Precariousness, and Insecurity
Samuel, Robin UL; Hupka-Brunner, Sandra; Bergman, Manfred Max

Scientific Conference (2010)

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See detailTransfer of strategy use by semantic recoding in arithmetic problem solving
Gamo, Sylvie UL; Sander, Emmanuel; Richard, Jean-François

in Learning and Instruction (2010), 20

Transfer of strategies between problems sharing the same formal structure is facilitated by a semantic recoding that makes evident the structural similarities between the problems. Two experiments were ... [more ▼]

Transfer of strategies between problems sharing the same formal structure is facilitated by a semantic recoding that makes evident the structural similarities between the problems. Two experiments were carried out among 4th and 5th grade pupils, with an experimental group trained to compare strategies in order to reinterpret an arithmetic word problem so that the calculations are consistent with the interpretation, and a control group. The experimental group in Experiment 1 improved significantly by choosing the alternative strategy in problems different from those used in training but no significant progress was observed in the control group. Experiment 2 showed that the improvement observed in the experimental group could not be attributed to the fact that children only learned to use a superficial rule. These results support the idea that the activity of problem re-representation may be a crucial step in mathematization. [less ▲]

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See detailTransfer pricing rules, OECD guidelines, and market distortions
Behrens, Kristian; Peralta, Susana; Picard, Pierre M. UL

in Journal of Public Economic Theory (2014)

We study the impact of transfer pricing rules on sales prices, firms' organizational structure, and consumers' utility within a two-country monopolistic competition model featuring source-based profit ... [more ▼]

We study the impact of transfer pricing rules on sales prices, firms' organizational structure, and consumers' utility within a two-country monopolistic competition model featuring source-based profit taxes that differ across countries. Firms can either become multinationals, i.e., they serve the foreign market through a fully controlled a¢ liate; or they can become exporters, i.e., they serve the foreign market by contracting with an independent distributor. Compared to the benchmark cases, where tax authorities are either unable to audit firms or where they are able to audit them perfectly, the use of the OECD's Comparable Uncontrolled Price (CUP) or Cost-Plus (CP) rule distorts firms' output and pricing decisions. The reason is that the comparable arm's length transactions between exporters and distributors, which serve as benchmarks, are not efficient. We show that implementing the CUP or CP rules is detrimental to consumers in the low tax country, yet benefits consumers in the high tax country. [less ▲]

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See detailTransfereffekte bei der Selbstregulation von Übungsbedingungen
Bund, Andreas UL

Scientific Conference (2003, January)

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See detailTransferpotenziale des deutschen dualen Studiums. Eine Bestimmung zentraler Faktoren anhand der Fallstudien Brasilien und Frankreich
Graf, Lukas UL; Powell, Justin J W UL; Bernhard, Nadine

in Berufsbildung in Wissenschaft und Praxis (2014), 6/2014

Dem dualen Studium wird das Potenzial zugesprochen, eine wichtige Rolle bei der Kompetenzentwicklung für Berufe des 21. Jahrhunderts zu spielen. Bislang sind duale Studiengänge vor allem ein deutsches ... [more ▼]

Dem dualen Studium wird das Potenzial zugesprochen, eine wichtige Rolle bei der Kompetenzentwicklung für Berufe des 21. Jahrhunderts zu spielen. Bislang sind duale Studiengänge vor allem ein deutsches Phänomen. Derzeit trifft dieses Studienmodell jedoch vermehrt auf das Interesse von ausländischen Bildungsakteuren, die gezielt nach Modellen zur besseren Verknüpfung akademischer und berufspraxisbezogener Lernerfahrungen suchen. Anhand der Länder Frankreich und Brasilien werden allgemeine Bedingungen für einen erfolgreichen Transfer dieses Studienmodells und Möglichkeiten der binationalen Kooperation analysiert. [less ▲]

Detailed reference viewed: 159 (22 UL)