References of "Zhang, Weiqi"
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See detailEnvironmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis
Sakalem, Marna Eliana; Seidenbecher, Thomas; Zhang, Mingyue et al

in Hippocampus (2016)

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See detailInduced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain
Hemmer, Kathrin UL; Zhang, Mingyue; van Wuellen, Thea et al

in Stem Cell Reports (2014)

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See detailModelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.
Liu, Guang-Hui; Suzuki, Keiichiro; Li, Mo et al

in Nature communications (2014), 5

Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not ... [more ▼]

Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we derive integration free-induced pluripotent stem cells (iPSCs) from an FA patient without genetic complementation and report in situ gene correction in FA-iPSCs as well as the generation of isogenic FANCA-deficient human embryonic stem cell (ESC) lines. FA cellular phenotypes are recapitulated in iPSCs/ESCs and their adult stem/progenitor cell derivatives. By using isogenic pathogenic mutation-free controls as well as cellular and genomic tools, our model serves to facilitate the discovery of novel disease features. We validate our model as a drug-screening platform by identifying several compounds that improve hematopoietic differentiation of FA-iPSCs. These compounds are also able to rescue the hematopoietic phenotype of FA patient BM cells. [less ▲]

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