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See detailProinflammatory T Cell Status Associated with Early Life Adversity
Elwenspoek, M.M.C.; Hemgesch, X.; Leenen, F.A.D et al

in Journal of Immunology (2017)

Early life adversity (ELA) has been associated with an increased risk for diseases in which the immune system plays a critical role. The ELA immune phenotype is characterized by inflammation, impaired ... [more ▼]

Early life adversity (ELA) has been associated with an increased risk for diseases in which the immune system plays a critical role. The ELA immune phenotype is characterized by inflammation, impaired cellular immunity, and immunosenescence. However, data on cell-specific immune effects are largely absent. Additionally, stress systems and health behaviors are altered in ELA, which may contribute to the generation of the ELA immune phenotype. The present investigation tested cell-specific immune differences in relationship to the ELA immune phenotype, altered stress parameters, and health behaviors in individuals with ELA (n = 42) and those without a history of ELA (control, n = 73). Relative number and activation status (CD25, CD69, HLA-DR, CD11a, CD11b) of monocytes, NK cells, B cells, T cells, and their main subsets were assessed by flow cytometry. ELA was associated with significantly reduced numbers of CD69+CD8+ T cells (p = 0.022), increased numbers of HLA-DR+ CD4 and HLA-DR+ CD8 T cells (p < 0.001), as well as increased numbers of CD25+CD8+ T cells (p = 0.036). ELA also showed a trend toward higher numbers of CCR4+CXCR3−CCR6+ CD4 T cells. Taken together, our data suggest an elevated state of immune activation in ELA, in which particularly T cells are affected. Although several aspects of the ELA immune phenotype were related to increased activation markers, neither stress nor health-risk behaviors explained the observed group differences. Thus, the state of immune activation in ELA does not seem to be secondary to alterations in the stress system or health-risk behaviors, but rather a primary effect of early life programming on immune cells. [less ▲]

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See detailRejection sensitivity as a vulnerability marker for depressive symptom deterioration in men.
De Rubeis, Jannika; Lugo, Ricardo; Witthöft, Michael et al

in PLoS ONE (2017), 12(10), 0185802

Consistent across time and cultures, men and male adolescents older than 14 years of age appear underrepresented in mood disorders, and are far less likely than women to seek psychological help. The much ... [more ▼]

Consistent across time and cultures, men and male adolescents older than 14 years of age appear underrepresented in mood disorders, and are far less likely than women to seek psychological help. The much higher rate of suicide amongst males suggests that depression in men might be underreported. One of the core human motives is to seek acceptance by others and avoid rejection. Rejection Sensitivity (RS) has been conceptualized as the cognitive-affective processing disposition to anxiously expect, readily perceive, and intensely respond to cues of rejection in the behavior of others. RS has been previously linked with the onset and course of depression, but - as yet - has not been investigated longitudinally in a clinical population. We investigated the predictive role of RS to symptom deterioration 6 months after end-of- treatment in 72 male inpatients with depressive spectrum disorder. The BDI was administered at intake, end-of-treatment and 6 month follow-up. RS scores were obtained at intake. Rejection Sensitivity had additional predictive power on BDI scores at 6 months follow-up controlling for BDI scores at end-of-treatment (ΔR2 = .095). The results are discussed in terms of the importance of targeting RS during treatment, and highlight the fact that therapeutic follow-up care is paramount. Future research should investigate possible mediators of the RS- relapse-to-depression association, such as self-blame, rumination, neuroticism, pessimism, emotion dysregulation, and low self-esteem. [less ▲]

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See detailT cell immunosenescence after early life adversity: association with cytomegalovirus infection.
Elwenspoek, M.M.C.; Sias, K.; Hengesch, X. et al

in Frontiers in Immunology (2017), 8

Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health ... [more ▼]

Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem. Immunosenescence, or aging of the immune system, has been proposed to underlie the association between ELA and long-term health consequences. However, it is unclear what drives ELA-associated immunosenescence and which cells are primarily affected. We investigated different biomarkers of immunosenescence in a healthy subset of the EpiPath cohort. Participants were either parent-reared (Ctrl, n = 59) or had experienced separation from their parents in early childhood and were subsequently adopted (ELA, n = 18). No difference was observed in telomere length or in methylation levels of age-related CpGs in whole blood, containing a heterogeneous mixture of immune cells. However, when specifically investigating T cells, we found a higher expression of senescence markers (CD57) in ELA. In addition, senescent T cells (CD57+) in ELA had an increased cytolytic potential compared to senescent cells in controls. With a mediation analysis we demonstrated that cytomegalovirus (CMV) infection, which is an important driving force of immunosenescence, largely accounted for elevated CD57 expression observed in ELA. Leukocyte telomere length may obscure cell-specific immunosenescence; here, we demonstrated that the use of cell surface markers of senescence can be more informative. Our data suggest that ELA may increase the risk of CMV infection in early childhood, thereby mediating the effect of ELA on T cell-specific immunosenescence. Thus, future studies should include CMV as a confounder or selectively investigate CMV seronegative cohorts. [less ▲]

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See detailPlace, green exercise and stress: an exploration of lived experience and restorative effects
Olafsdottir, Gunnthora; Cloke, Paul; Vögele, Claus UL

in Health & Place (2017), 46

This paper reports on inter-disciplinary research designed to investigate the stress-buffering effects of green exercise, and the importance of the context in which exercise takes place. This ... [more ▼]

This paper reports on inter-disciplinary research designed to investigate the stress-buffering effects of green exercise, and the importance of the context in which exercise takes place. This investigation of context effects examines both individual physiological responses (salivary cortisol) and the phenomenological interpretation of lived experiences of the intervention, reported by a subsample of participants in a randomized, controlled trial, in which healthy, physically inactive university students were randomly allocated to three activities: walking on a treadmill in a gym, walking in semi-natural recreational area, and sitting and watching nature-based videos on TV. The study found clear indications of context effects, notably in the connections between positive appraisals of perceived circumstances, enjoyment in the enacted context, and physiological stress-reduction. [less ▲]

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See detailCommunity- and mHealth-based integrated management of diabetes in primary healthcare in Rwanda (D²Rwanda): The study protocol
Uwizihiwe, Jean Paul; Lygidakis, Charilaos UL; Vögele, Claus UL et al

Scientific Conference (2017, June 29)

Introduction: The diabetes mellitus (DM) prevalence in Rwanda is estimated at 3.5%. In 2013, there were only one medical doctor and one nurse per 15,000 and 1,200 people respectively in Rwanda. A new ... [more ▼]

Introduction: The diabetes mellitus (DM) prevalence in Rwanda is estimated at 3.5%. In 2013, there were only one medical doctor and one nurse per 15,000 and 1,200 people respectively in Rwanda. A new programme employing frontline workers (Home-Based Community Practitioners (HBCPs)) is currently piloted, aiming at following-up patients with non-communicable diseases in their communities. We hypothesise that the management of DM at community level will improve following the introduction of a HBCP programme with regular monthly assessments and disease management, coupled with integration of a mobile health (mHealth) application with patient diaries, notifications and educational material. Objective: The aim of the study is to determine the efficacy of such an integrated programme in Rwanda. Methods: The study is designed as a one-year, open-label cluster trial of two interventions (arm1: HBCP programme, arm2: HBCP programme + mHealth application) and usual care (control). The primary outcomes will be changes in glycated haemoglobin levels and health-related quality of life. Mortality, complications, health literacy, mental well-being and treatment adherence will be assessed as secondary outcomes. Measurements will be conducted at baseline, 6 and 12 months. An intention-to-treat approach will be used to evaluate outcomes. Before trial onset, ethical approval will be sought in Rwanda, Luxembourg and Denmark, and a cross-cultural adaptation of questionnaires and a pilot will be carried out. Relevance: The project will provide evidence on the efficacy of innovative approaches for integrated management of DM and may spur the development of similar solutions for other chronic diseases in low-resource settings. [less ▲]

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See detailDepression Burden in Luxembourg: Individual Risk Factors, Geographic Variations and the Role of Migration, 2013-2015 European Health Examination Survey
Ruiz-Castell, Maria; Kandala, Ngianga-Bakwin; Perquin, Magali et al

in Journal of Affective Disorders (2017), 222

Background: Depression is a complex mental disorder that affects an increasing proportion of the worldwide population. This study aims to estimate the prevalence of depressive symptoms in Luxembourg ... [more ▼]

Background: Depression is a complex mental disorder that affects an increasing proportion of the worldwide population. This study aims to estimate the prevalence of depressive symptoms in Luxembourg, associated risk factors and geographic variations. Additionally, it aims to assess whether first and second generation immigrants are at higher risk for depressive symptoms compared to non-immigrants. Methods: Representative cross-sectional data from 1499 residents of Luxembourg, aged 25 to 64 years, were collected from the Luxembourg European Health Survey (EHES-LUX). Depressive symptoms were defined as a score of ≥5 on the Patient Health Questionnaire for depression (PHQ-9) (i.e. mild, moderate or severe). Standard and Bayesian regression models were used to examine associations between depressive symptoms, immigration status and geographic distribution across Luxembourg. Results: The prevalence of depressive symptoms was 21.55% (15.54% mild, 3.54% moderate, and 2.49% moderately severe to severe). The odds of having depressive symptoms was higher among second generation immigrants compared to non-immigrants (OR: 1.58, 95% CI: 1.04, 2.41), independent of socioeconomic and behavioral characteristics. Healthier diet, higher social support and good health perception were protective towards experiencing depressive symptoms. One of the highest likelihoods of reporting depressive symptoms was observed in the South-West of the country with a positive effect at 80% credible region [CR] (1.42 [0.92, 2.73]). Limitations: The participation rate was low (26.7%). The cross-sectional nature of the study does not allow us to establish causality. Conclusions: Depression constitutes an important public health challenge in Luxembourg due to the impact on the overall health of the population. Social programs of health promotion should be developed to improve mental wellbeing in immigrants, especially those of second generation. [less ▲]

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See detailDigital health in ambulatory assessment
Vögele, Claus UL

Book published by INSIDE (2017)

In this volume all accepted contributions to the 5th Biennial Conference of the Society for Ambulatory Assessment are published. The number and quality of these contributions testify to the high standard ... [more ▼]

In this volume all accepted contributions to the 5th Biennial Conference of the Society for Ambulatory Assessment are published. The number and quality of these contributions testify to the high standard of international research in ambulatory monitoring, the rapid advances in technology and data handling supporting ambulatory assessment, and the importance of these developments for the rapidly expanding area of Digital Health. Converging technologies such as Internet applications, social networks, smartphones and wearable sensors in the area of health, are now beginning to transform our approach to health research, healthcare, and communication and access to information. [less ▲]

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See detailMood, emotions and eating disorders
Vögele, Claus UL; Lutz, Annika UL; Gibson, E. Leigh

in Agras, W. Stewart; Hagler Robinson, Athena (Eds.) The Oxford Handbook of Eating Disorders, Second Edition (2017)

Mood and emotions are intrinsically involved with eating. This chapter discusses basic mechanisms, findings, and models that help our understanding of the interactions between eating and emotions, in both ... [more ▼]

Mood and emotions are intrinsically involved with eating. This chapter discusses basic mechanisms, findings, and models that help our understanding of the interactions between eating and emotions, in both clinical and nonclinical populations. The finding that negative affect predicts EDs transdiagnostically, and that comorbidity with depressive disorders and anxiety disorders is the norm among patients with EDs suggests that EDs may not necessarily be restricted to domains of eating behavior and body image but may also be associated with significant difficulties in affective functioning. This chapter reviews the evidence relating to the notion that EDs are disturbances of mood regulation, in which regulatory strategies specifically related to eating and the body are used to diminish negative affect associated with food, body image, or stress. [less ▲]

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See detailGeneralized hypervigilance in fibromyalgia: normal interoceptive accuracy, but reduced self-regulatory capacity
Rost, Silke UL; van Ryckeghem, Dimitri UL; Schulz, André UL et al

in Journal of Psychosomatic Research (2017), 93(2), 48-54

Objective: The factors underlying the aetiology of fibromyalgia (FM) are largely unknown. According to the generalized hypervigilance hypothesis (GHH), FM patients show excessive attention towards pain ... [more ▼]

Objective: The factors underlying the aetiology of fibromyalgia (FM) are largely unknown. According to the generalized hypervigilance hypothesis (GHH), FM patients show excessive attention towards pain stimuli and other sensory events, thereby increasing pain perception and dysfunctional behaviour. We tested this notion by assessing interoceptive accuracy (IA) in FM patients and matched healthy controls. We also tested the hypothesis that FM is characterized by reduced self-regulatory capacity as indexed by heart rate variability (HRV). Methods: 47 FM patients (Mage = 45.5, 39 females) and 45 healthy controls (Mage = 44.9, 37 females) completed several self-report scales (Body Vigilance Scale, Depression Anxiety Stress Scales, Pain Catastrophizing Scale). To derive HRV, heart rate was monitored under resting conditions; for the assessment of IA participants performed a heartbeat tracking task in which they were asked to silently count their heartbeats. Results: FM patients reported higher body vigilance than healthy controls, but there were no group differences in IA. FM patients had lower HRV compared with healthy controls. HRV did not predictor IA. Conclusion: In conclusion, our findings do not support the hypothesis of generalized hypervigilance in FM patients. Patients reported a heightened focus on bodily sensations, which was not reflected in IA. It may be that hypervigilance is not a general and stable characteristic but is rather context dependent and modality-specific. [less ▲]

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See detailAngst vor körperlicher Bewegung bei Patienten mit Herzinsuffizienz und gesunden Senioren – Ein psychophysiologisches Experiment basierend auf dem Schreckreflex-Paradigma
Hoffmann, Jeremy; Finke, Johannes; Vögele, Claus UL et al

in Schorr, A. (Ed.) Abstractband 13. Kongress der Fachgruppe Gesundheitspsychologie der DGPs (2017)

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See detailLangzeitkonsequenzen von frühkindlichem Stress: quadratischer Zusammenhang zwischen Stress und Interozeptionsfähigkeit
Schaan, Violetta UL; Schulz, André UL; Vögele, Claus UL

in Schächinger, H. (Ed.) Abstractband 43. Tagung Psychologie und Gehirn (2017)

Traumatische Belastungen während der Kindheit können das Risiko für die Entwicklung unsicherer Bindungsstile erhöhen, die bereits mit langfristigen psychischen und körperlichen Gesundheitsproblemen in ... [more ▼]

Traumatische Belastungen während der Kindheit können das Risiko für die Entwicklung unsicherer Bindungsstile erhöhen, die bereits mit langfristigen psychischen und körperlichen Gesundheitsproblemen in Beziehung gebracht wurden. Die zugrundeliegenden Prozesse sind allerdings noch weitestgehend unklar. Da interozeptive Signale die Regulation negativer Emotionen als Reaktion auf sozialer Zurückweisung begünstigen können, die infolge einer Stressbelastung verändert sein könnten, wurde insbesondere der Effekt von kindlichem Stress auf Interozeption untersucht. Wir präsentieren zwei Studien, die den Zusammenhang zwischen kindlichem Stress und Gesundheit im Erwachsenenalter sowie Körperwahrnehmung und Gedächtnisfähigkeit untersuchen. In der ersten Studie nahmen 199 Teilnehmer an einer Onlineumfrage teil, bei der Gesundheit, frühkindliches Trauma, Resilienz und Zurückweisungssensitivität gemessen wurden. Teilnehmer mit geschiedenen Eltern berichteten erhöhte psychische Belastungswerte, kindliches Trauma, Zurückweisungssensitivität und weniger Resilienz. Die Beziehung zwischen elterlicher Scheidung und psychischer Gesundheit konnte vollständig durch diese vier Faktoren erklärt werden (Varianzaufklärung 44%). In einer zweiten Studie wurden bei 60 Teilnehmern verschiedene Selbstberichts-Parameter erhoben und die Gedächtnis- und Interozeptionsfähigkeit (Schandry Herzschlagwahrnehmungstest/EKG) vor und nach einem sozial-evaluativen Kaltwasser-Stresstest untersucht. Die Reaktion des autonomen Nervensystems wurde mithilfe von Herzraten- und Blutdruckvariabilität bestimmt. Erwachsene mit einer Vorgeschichte von elterlicher Trennung berichteten mehr bindungsbezogene Angst und Vermeidung als Kontrollpersonen. Das Erlebnis einer elterlichen Scheidung war negativ mit der Gedächtnisleistung nach dem Stresstest korreliert. Weiterhin weisen die Ergebnisse auf einen quadratischen Zusammenhang zwischen kindlicher Stressbelastung und Interozeptionsfähigkeit hin. Basierend auf diesen Ergebnissen könnte ein ‚gesunder Normbereich‘ der Interozeptionsfähigkeit existieren. Kindlicher Stress könnte sowohl eine Verringerung, als auch eine Erhöhung der Interozeptionsfähigkeit bewirken, was beides mit gesundheitlichen Problemen assoziiert sein könnte. [less ▲]

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See detailGrand challenges in eating behavior research: preventing weight gain, facilitating long-term weight maintenance
Meule, Adrian; Vögele, Claus UL

in Frontiers in Psychology (2017), 8

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See detailZusammenhang zwischen interozeptiver Genauigkeit und kardiovaskulärer Veränderung nach akutem Stress bei gesunden Frauen
Rost, Silke UL; Van Dyck, Zoé UL; Schulz, André UL et al

in Schächinger, H. (Ed.) Abstractband 43. Tagung Psychologie und Gehirn (2017)

Einleitung:Interozeption als afferente und Stressverarbeitung als efferente Informationsverarbeitung können als komplementär hinsichtlich der Kommunikation zwischen Körper und Gehirn verstanden werden. Es ... [more ▼]

Einleitung:Interozeption als afferente und Stressverarbeitung als efferente Informationsverarbeitung können als komplementär hinsichtlich der Kommunikation zwischen Körper und Gehirn verstanden werden. Es wurde gezeigt, dass stressbedingte veränderte kardiovaskuläre Prozesse mit veränderter Interozeption zusammenhängen und in körperlichen Beschwerden resultieren können. Wenig erforscht ist in diesem Kontext jedoch die psychologische sowie physiologische Erregung, welche mit einem akuten mentalen Stressor einhergeht. Ziel der vorliegenden Studie ist es, diese Lücke zu schließen und den Zusammenhang zwischen interozeptiver Genauigkeit und kardiovaskulärer Reaktivität und Erholung nach einem mentalen Stressor in einer gesunden Stichprobe zu untersuchen. Methode: Es wurde die Pulsfrequenz von 69 Frauen (MAlter = 24.20 Jahre, Range 18-50 Jahre; MBMI = 23.19, Range 17.19-34.48) zur späteren Bestimmung der Herzratenvariabilität (HRV) gemessen. Zur Bestimmung der interozeptiven Genauigkeiten führten die Teilnehmerinnen eine Herzschlagzählaufgabe durch und als mentalen Stressor setzten wir eine choice reaction time task (CRTT) ein. Die Pulsfrequenz wurde während der CRTT sowie während einer 10-minütigen Erholungsphase aufgezeichnet um Werte der kardiovaskulären Stressreaktivität und – erholung zu erfassen. Ergebnisse: DieErgebnisse zeigten keinen Zusammenhang zwischen interozeptiver Genauigkeit und HRV-Reaktivität auf akuten mentalen Stress (r = .042, p = .785). Der Zusammenhang zwischen interozeptiver Genauigkeit und kardiovaskulärer Stresserholung nach der CRTT war negativ (r = -.377; p = .012). Diskussion: Ergebnisse der vorliegenden Studie liefern erste Hinweise dafür, dass eine gute Interozeptionsfähigkeit mit einer besseren kardiovaskulären Erholung nach einem mentalen Stressor zusammenhängen, d.h. kardiovaskuläre Prozesse positiv beeinflussen kann. Interventionen zur Verbesserung der Interozeptionsfähigkeit könnten kardiovaskuläre Erholung erleichtern und das damit einhergehende Risiko zukünftiger Herz-Kreislauf- Probleme verringern. [less ▲]

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See detailGastric modulation of startle eye blink
Schulz, André UL; Van Dyck; Lutz, Annika UL et al

in Biological Psychology (2017), 127(1), 25-33

Abstract: Previous assessment methods of gastric interoception either rely on self-reports, or imply invasive procedures. We investigated the reliability of startle methodology as a non-invasive ... [more ▼]

Abstract: Previous assessment methods of gastric interoception either rely on self-reports, or imply invasive procedures. We investigated the reliability of startle methodology as a non-invasive alternative for the assessment of afferent gastric signals. Twenty-four participants were tested on three separate days, on which they were requested to ingest water (either 0, 300 or 600 ml), after 8 h of fasting. On each assessment day, eye blink responses (EMG) to 10 acoustic startle stimuli (105 dB) were assessed at 4 measurement points (before, 0, 7, 14 min. after ingestion). Increased normogastric responses (EGG), ratings of satiety and fullness, and higher heart rate variability (RMSSD) suggested effective non-invasive induction of gastric distention. Startle responses were lower directly after ingestion of 600 ml as compared to earlier and later measurements. These results suggest that startle methodology provides a reliable method to investigate afferent gastric signals. It could be useful to study possible dissociations between subjective reports and objective afferent gastric signals in eating or somatoform disorders. [less ▲]

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See detailSleep and somatic complaints in university students
Schlarb, Angelika; Claßen, Merle; Hellmann, Sara et al

in Journal of Pain Research (2017), 10

Background: Sleep problems are common among university students. Poor sleep is associated with impaired daily functioning, increased risk of psychiatric symptoms, and somatic complaints such as pain ... [more ▼]

Background: Sleep problems are common among university students. Poor sleep is associated with impaired daily functioning, increased risk of psychiatric symptoms, and somatic complaints such as pain. Previous results suggest that poor sleep exacerbates pain, which in turn negatively affects sleep. The purpose of the present study was to determine prevalence rates, comorbidity, and role of depression as a factor of moderating the relationship between sleep and physical complaints in German university students. Samples and methods: In total, 2443 German university students (65% women) completed a web survey. Self-report measures included the Pittsburg Sleep Quality Index, three modules of the Patient Health Questionnaire, and a questionnaire on the functional somatic syndromes (FSSs). Results: More than one-third (36.9%) reported poor sleep as assessed by the Pittsburgh Sleep Quality Index. Somatoform syndrome was identified in 23.5%, and the prevalence of any FSS was 12.8%. Self-reported sleep quality, sleep onset latency, sleep disturbances, use of sleep medications, and daytime dysfunctioning were significant predictors of somatoform syndrome, whereas sleep efficiency and sleep duration influenced somatic complaints indirectly. Moderate correlations were found between stress, anxiety, somatoform syndrome, depression, and overall sleep quality. The effect of somatic complaints on sleep quality was associated with the severity of depression. Anxiety shows direct effects on somatization and depression but only indirect associations with sleep quality. [less ▲]

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See detailLangzeitkonsequenzen von frühkindlichem Stress
Schaan, Violetta UL; Schulz, André UL; Vögele, Claus UL

Poster (2017)

Traumatische Belastungen während der Kindheit können das Risiko für die Entwicklung unsicherer Bindungsstile erhöhen, die bereits mit langfristigen psychischen und körperlichen Gesundheitsproblemen in ... [more ▼]

Traumatische Belastungen während der Kindheit können das Risiko für die Entwicklung unsicherer Bindungsstile erhöhen, die bereits mit langfristigen psychischen und körperlichen Gesundheitsproblemen in Beziehung gebracht wurden. Die zugrundeliegenden Prozesse sind allerdings noch weitestgehend unklar. Wir präsentieren zwei Studien, die den Zusammenhang zwischen kindlichem Stress und Gesundheit im Erwachsenenalter sowie Körperwahrnehmung und Gedächtnisfähigkeit untersuchen. In der ersten Studie nahmen 199 Teilnehmer an einer Onlineumfrage teil, bei der Gesundheit, frühkindliches Trauma, Resilienz und Zurückweisungssensitivität gemessen wurden. Teilnehmer mit geschiedenen Eltern berichteten erhöhte psychische Belastungswerte, kindliches Trauma, Zurückweisungssensitivität und weniger Resilienz. Die Beziehung zwischen elterlicher Scheidung und psychischer Gesundheit konnte vollständig durch diese vier Faktoren erklärt werden (Varianzaufklärung 44%). In einer zweiten Studie wurden bei 60 Teilnehmern verschiedene Selbstbericht-Parameter erhoben und die Gedächtnis- und Interozeptionsfähigkeit vor und nach einem Stresstest untersucht. Erwachsene mit einer Vorgeschichte von elterlicher Trennung berichteten mehr bindungsbezogene Angst und Vermeidung als Kontrollpersonen. Das Erlebnis einer elterlichen Scheidung war negativ mit der Gedächtnisleistung nach dem Stresstest korreliert. Weiterhin weisen die Ergebnisse auf einen quadratischen Zusammenhang zwischen Stress und Interozeptionsfähigkeit hin. [less ▲]

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See detailSleep disturbances and mental strain in university students: results from an online survey in Luxembourg and Germany
Schlarb, Angelika; Claßen, Merle; Grünewald, Julia et al

in International Journal of Mental Health Systems (2017), 11

OBJECTIVES: This study examined the prevalence of sleep disturbances and mental strain in students from two European countries, Luxembourg and Germany. METHODS: A total of 2831 students took part in an ... [more ▼]

OBJECTIVES: This study examined the prevalence of sleep disturbances and mental strain in students from two European countries, Luxembourg and Germany. METHODS: A total of 2831 students took part in an online survey, with 2777 students from Germany and 184 students from Luxembourg. Sleep disturbances were assessed with the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale, and aspects of mental strain using the Patient Health Questionnaire, the Social-Interactive-Anxiety Scale, the self-efficacy questionnaire and the test anxiety questionnaire. In addition, we also assessed students' chronotypes. RESULTS: Across the whole sample mean scores on the sleep questionnaires were above the cut-off for clinically relevant sleep problems, indicating an increased prevalence of sleep disturbances in students from both countries. Sleep quality was impaired in 42.8%, and 17.9% showed clinically relevant scores. Overall 25.5% reported elevated depression and 13.3% social phobia symptoms, while 45% indicated elevated stress levels. Sleep quality, daytime sleepiness, chronotype, depression scores, stress levels, test anxiety, and self-efficacy differed significantly between men and women, but there were no differences between countries. CONCLUSIONS: Sleep disturbances and mental strain in students are common, with the current results replicating previous findings. Students from Luxembourg and Germany are affected equally. [less ▲]

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See detailGreen exercise is associated with better cell ageing profiles
Olafsdottir, Gunnthora; Cloke, Paul; Epel, Elissa et al

in The European Journal of Public Health (2016, November 01), 26(Suppl 1), 165021

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See detailResilience and rejection sensitivity mediate long-term outcomes of parental divorce
Schaan, Violetta UL; Vögele, Claus UL

in European Child & Adolescent Psychiatry (2016), 25(11), 1267-1269

Introduction: Increasing divorce rates leave more and more children to deal with the separation of their parents. Recent research suggests that children of divorced parents more often experience ... [more ▼]

Introduction: Increasing divorce rates leave more and more children to deal with the separation of their parents. Recent research suggests that children of divorced parents more often experience psychological and physical symptoms than children of non-divorced parents. The processes that mediate the relationship between parental divorce and ill-health, however, are still elusive. The current study investigated the mediating role of psychological factors such as resilience and rejection sensitivity on the long-term consequences of parental divorce in young adults. Methods: One hundred and ninety-nine participants (mean age 22.3 years) completed an online survey including measures of mental health, childhood trauma, resilience and rejection sensitivity. Results: Participants with divorced parents (33%) reported increased levels of psychological symptoms, childhood trauma, rejection sensitivity and lower levels of resilience. The association between parental divorce and mental health was fully mediated by resilience, rejection sensitivity and childhood trauma. The mediation model explained up to 44% of the total variance in mental health symptoms. Discussion: Resilience and rejection sensitivity are crucial factors for successful coping with the experience of parental separation. Prevention programs that help to boost children’s resilience might help to reduce the long-term effects of parental divorce on their attachment style (e.g. rejection sensitivity), thereby improving their mental health on the long run. Furthermore, the results call for parental awareness and counseling to target and reduce the observed increased level of childhood trauma. Limitations concern the cross-sectional and retrospective design of the study. [less ▲]

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