References of "Turner, Jonathan D"
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See detailEpigenetic regulation of the glucocorticoid receptor promoter 1 7 in adult rats
Witzmann, Simone UL; Turner, Jonathan D.; Mériaux, Sophie B. et al

in Epigenetics : Official Journal of the DNA Methylation Society (2012), 7(11), 1290-1301

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See detailThe chromosome 15q14 locus for bipolar disorder and schizophrenia: Is C15orf53 a major candidate gene?
Kranz, Thorsten M.; Ekawardhani, Savira; Lin, Michelle K. et al

in Journal of Psychiatric Research (2012), 46(11), 1414-1420

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See detailDecreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder
Klok, Melanie D.; Alt, Simone UL; Irurzun Lafitte, Alicia J. et al

in Journal of Psychiatric Research (2011), 45(7), 871-78

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See detailTranscriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more
Turner, Jonathan D.; Alt, Simone UL; Cao, Lei et al

in Biochemical Pharmacology (2010), 80(12), 1860-68

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See detailStress induces methylation of the E2F1 regulated glucocorticoid receptor promoter 1F
Alt, Simone UL; Cao, Lei; Leija, Salomon C. et al

Scientific Conference (2010)

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See detailDifferential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed
Alt, Simone UL; Turner, Jonathan D.; Klok, Melanie D. et al

in Psychoneuroendocrinology (2010), 35(4), 544-56

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See detailMineralocorticoid receptor is downregulated in hippocampus and cingulate gyrus of depressed patients; evidence for a MR/GR imbalance
Irurzun-Lafitte, Alicia J.; Klok, Melanie D.; Alt, Simone UL et al

Scientific Conference (2009)

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See detailChanges of Glucocorticoid receptor first exon variants in major depressive disorder
Alt, Simone UL; Turner, Jonathan D.; Klok, Melanie D. et al

Scientific Conference (2008)

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See detailAlternative glucocorticoid receptor first exon usage in major depressive disorder
Alt, Simone UL; Turner, Jonathan D.; Klok, Melanie D. et al

Scientific Conference (2008)

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See detailNuclear receptors in human immune cells: expressions and correlations
Muller, Claude P.; Schiltz, Jang UL; Turner, Jonathan D. et al

in Molecular Immunology (2007), 44

Nuclear receptors (NR) are key modulators of gene transcription. Their activity is ligand induced and modulates a large variety of tissue-specific cellular functions. However, for many NR little is known ... [more ▼]

Nuclear receptors (NR) are key modulators of gene transcription. Their activity is ligand induced and modulates a large variety of tissue-specific cellular functions. However, for many NR little is known about their role in cells of the immune system. In this study, expression patterns and distribution of 24 NR were investigated in human peripheral blood mononuclear cells.We provide the first evidence of the expression of the 12 receptors CAR, CoupTF , CoupTF , FXR, GCNF, HNF4 , PPAR / , PXR, RevErb , TR2, TR4 and TLX in highly purified CD4, CD8, CD19, CD14 cells. The expression profile of RevErb and LXR previously observed in B cell and macrophages, respectively, has been extended to CD4, CD8 and CD14 cells. Except for RAR , which was absence in any of the cells tested, our results suggest an almost ubiquitous expression of the NR in the different cell lineages of the immune system. The expression of CAR, CoupTF , FXR was also confirmed at a protein level and despite conspicuous mRNA levels of HNF4 , only low levels of this receptor were detectable in the nuclear fraction of PBMCs. Expression of the latter receptors was mostly only a fraction (4–20%) of their expression in the thyroid gland, the adrenal gland, the lung or subcutaneous adipose tissue. The Spearman rank order correlation test was performed to examine the correlation in expression between individual nuclear receptor pairs in the four cell types for several donors. Distinct correlation patterns were observed between receptor pairs in the individual cell types. In CD4 T cells four NR, GCNF, PPAR , PPAR 7 and RevErb are perfectly correlated with each other (P≥0.0167). In the other cell types correlations betweenNRpairs were more diverse, but also statistically highly significant. Interestingly, the relative expression level of a number of receptor pairs ranked identical or similar in at least three (CoupTF and PPAR / , CoupTF andHNF4 as well asROR and PXR) or four cell types (CoupTF and CoupTF , PPAR and RevErb ). Despite the variability of NR expression in immune cells, these results suggest that some of the NR may be co-regulated in human immune cells. [less ▲]

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