References of "Priami, Corrado"
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See detailCrowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Allen, Genevera; Amoroso, Nicola; Anghel, Catalina et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2016), 12(6), 645-653

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See detailDiversity of key players in the microbial ecosystems of the human body.
Jordan, Ferenc; Lauria, Mario; Scotti, Marco et al

in Scientific reports (2015), 5

Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability ... [more ▼]

Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among bacterial OTUs in 11 locations of the human body. These belong to two major groups. One is the digestive system and the other is the female genital tract. In each local ecosystem we determine the key species, both the ones being in key positions in the interaction network and the ones that dominate by frequency. Beyond identifying the key players and discussing their biological relevance, we also quantify and compare the properties of the 11 networks. The interaction networks of the female genital system and the digestive system show totally different architecture. Both the topological properties and the identity of the key groups differ. Key groups represent four phyla of prokaryotes. Some groups appear in key positions in several locations, while others are assigned only to a single body part. The key groups of the digestive and the genital tracts are totally different. [less ▲]

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See detailNovel drug target identification for the treatment of dementia using multi-relational association mining
Nguyen, Thanh Phuong UL; Priami, Corrado; Caberlotto, Laura

in Scientific Reports (2015), 5

Dementia is a neurodegenerative condition of the brain in which there is a progressive and permanent loss of cognitive and mental performance. Despite the fact that the number of people with dementia ... [more ▼]

Dementia is a neurodegenerative condition of the brain in which there is a progressive and permanent loss of cognitive and mental performance. Despite the fact that the number of people with dementia worldwide is steadily increasing and regardless of the advances in the molecular characterization of the disease, current medical treatments for dementia are purely symptomatic and hardly effective. We present a novel multi-relational association mining method that integrates the huge amount of scientific data accumulated in recent years to predict potential novel targets for innovative therapeutic treatment of dementia. Owing to the ability of processing large volumes of heterogeneous data, our method achieves a high performance and predicts numerous drug targets including several serine threonine kinase and a G-protein coupled receptor. The predicted drug targets are mainly functionally related to metabolism, cell surface receptor signaling pathways, immune response, apoptosis, and long-term memory. Among the highly represented kinase family and among the G-protein coupled receptors, DLG4 (PSD-95), and the bradikynin receptor 2 are highlighted also for their proposed role in memory and cognition, as described in previous studies. These novel putative targets hold promises for the development of novel therapeutic approaches for the treatment of dementia. [less ▲]

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See detailInference of Autism-Related Genes by Integrating Protein-Protein Interactions and miRNA-Target Interactions
Tran, Dang Hung; Nguyen, Thanh Phuong UL; Caberlotto, Laura et al

in Knowledge and Systems Engineering (2014)

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See detailNetwork analysis of neurodegenerative disease highlights a role of toll-like receptor signaling
Nguyen, Thanh Phuong UL; Caberlotto, Laura; Morine, Melissa J. et al

in BioMed Research International (2014), 2014

Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions ... [more ▼]

Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions between diseases are not always entirely clear. We present an efficient computationalmethod based on protein-protein interaction network (PPI) tomodel the functional network of NDs. The aim of this work is fourfold: (i) reconstruction of a PPI network relating to the NDs, (ii) construction of an association network between diseases based on proximity in the disease PPI network, (iii) quantification of disease associations, and (iv) inference of potentialmolecularmechanisminvolved in the diseases.The functional links of diseases not only showed overlap with the traditional classification in clinical settings, but also offered new insight into connections between diseases with limited clinical overlap. To gain an expanded view of the molecular mechanisms involved in NDs, both direct and indirect connector proteins were investigated. The method uncovered molecular relationships that are in common apparently distinct diseases and provided important insight into the molecular networks implicated in disease pathogenesis. In particular, the current analysis highlighted the Toll-like receptor signaling pathway as a potential candidate pathway to be targeted by therapy in neurodegeneration. [less ▲]

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See detailNetwork Inference from Time-Dependent Omics Data
Lecca, Paola; Nguyen, Thanh Phuong UL; Priami, Corrado et al

in Bioinformatics for Omics Data Methods in Molecular Biology (2011)

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See detailEM Clustering Based Approach to Decipher Functional Modules in Cross-Talking Signaling systems
Nguyen, Thanh Phuong UL; Ihekwaba, Adaoha E. C.; Priami, Corrado

in International Journal of Bioscience, Biochemistry and Bioinformatics (2011), 1(1), 1

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See detailModel-based clustering reveals vitamin D dependent multi-centrality hubs in a network of vitamin-related proteins
Nguyen, Thanh Phuong UL; Scotti, Marco; Morine, Melissa J. et al

in BMC Systems Biology (2011), 5(1), 195

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See detailDetecting Crosstalk Modules of Combined Networks: the Case for the NF-kappaB and p53
Nguyen, Thanh Phuong UL; Ihekwaba, Adaoha E. C.; Priami, Corrado

in Proceedings of IEEE International Conference on Bioscience, Biochemistry and Bioinformatics (2011)

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See detailElucidation of functional consequences of signalling pathway interactions
Ihekwaba, Adaoha E. C.; Nguyen, Thanh Phuong UL; Priami, Corrado

in BMC Bioinformatics (2009), 10(1), 370

Detailed reference viewed: 48 (0 UL)