References of "Okawa, Satoshi 50002782"
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See detailSignaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells
Medelnik, Jan-Philip; Roensch, Kathleen; Okawa, Satoshi UL et al

in Stem Cell Reports (2018)

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See detailRegulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere’s Disease
Frejo, Lidia; Requena, Teresa; Okawa, Satoshi UL et al

in Frontiers in Immunology (2017)

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See detailA systems biology approach to identify niche determinants of cellular phenotypes
Ravichandran, Srikanth UL; Okawa, Satoshi UL; Martinez Arbas, Susana UL et al

in Stem Cell Research (2016)

Recent reports indicate a dominant role for cellular microenvironment or niche for stably maintaining cellular phenotypic states. Identification of key niche mediated signaling that maintains stem cells ... [more ▼]

Recent reports indicate a dominant role for cellular microenvironment or niche for stably maintaining cellular phenotypic states. Identification of key niche mediated signaling that maintains stem cells in specific phenotypic states remains a challenge, mainly due to the complex and dynamic nature of stem cell-niche interactions. In order to overcome this, we consider that stem cells maintain their phenotypic state by experiencing a constant effect created by the niche by integrating its signals via signaling pathways. Such a constant niche effect should induce sustained activation/inhibition of specific stem cell signaling pathways that controls the gene regulatory program defining the cellular phenotypic state. Based on this view, we propose a computational approach to identify the most likely receptor mediated signaling responsible for transmitting niche signals to the transcriptional regulatory network that maintain cell-specific gene expression patterns, termed as niche determinants. We demonstrate the utility of our method in different stem cell systems by identifying several known and novel niche determinants. Given the key role of niche in several degenerative diseases, identification of niche determinants can aid in developing strategies for potential applications in regenerative medicine. [less ▲]

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See detailA differential network analysis approach for lineage specifier prediction in stem cell subpopulations
Okawa, Satoshi UL; Espinosa Angarica, Vladimir UL; Lemischka, Ihor et al

in Systems Biology and Applications (2015)

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See detailTranscriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells
W. van den Berg, Cathelijne; Okawa, Satoshi UL; M. Chuva de Sousa Lopes, Susana et al

in Development (2015)

Detailed reference viewed: 68 (8 UL)