References of "Nikiforidis, George"
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See detailNumerical study of magnetic particles concentration in biofluid (blood) under the influence of high gradient magnetic field in microchannel
Loukopoulos, Vassilios; Bourantas, Georgios UL; Labropoulos, Dimitrios et al

Scientific Conference (2016, June)

A meshless numerical scheme [1] is developed in order to simulate the magnetically mediated separation of biological mixture used in lab-on-chip devices as solid carriers for capturing, transporting and ... [more ▼]

A meshless numerical scheme [1] is developed in order to simulate the magnetically mediated separation of biological mixture used in lab-on-chip devices as solid carriers for capturing, transporting and detecting biological magnetic labeled entities [2], as well as for drug delivering, magnetic hyperthermia treatment, magnetic resonance imaging, magnetofection, etc. A modified one-way particle-fluid coupling analysis is considered to model the interaction of the base fluid of the mixture with the distributed particles motion. In details, bulk flow influences particle motion (through a simplified Stokes drag relation), while it is strongly dependent on particle motion through (particle) concentration. Due to the imposed magnetic field stagnation regions are developed, leading to the accumulation of the magnetic labeled species and finally to their collection from the heterogeneous mixture. The role of (i) the intensity of magnetic field and its gradient, (ii) the position of magnetic field, (iii) the magnetic susceptibility of magnetic particles, (iv) the volume concentration of magnetic particles (nanoparticles) and their size, (v) the flow velocity in the magnetic- fluidic interactions and interplay between the magnetophoretic mass transfer and molecular diffusion are thoroughly investigated. Both Newtonian and non-Newtonian blood flow models are considered, along with different expressions for the concentration and numerical results are presented for a wide range of physical parameters (Hartmann number (Ha), Reynolds number (Re)). A comprehensive study investigates their impact on the biomagnetic separation. For verification purposes, the numerical results obtained by the proposed meshless scheme were compared with established numerical results from the literature, being in excellent agreement. [less ▲]

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See detailNumerical Solution of Non-Isothermal Fluid Flows Using Local Radial Basis Functions (LRBF) Interpolation and a Velocity-Correction Method
Bourantas, Georgios UL; Skouras, Eugene; Loukopoulos, Vasilis et al

in Computer Modeling in Engineering & Sciences (2010), 64(2), 187-212

Meshfree point collocation method (MPCM) is developed, solving the velocity-vorticity formulation of Navier-Stokes equations, for two-dimensional, steady state incompressible viscous flow problems in the ... [more ▼]

Meshfree point collocation method (MPCM) is developed, solving the velocity-vorticity formulation of Navier-Stokes equations, for two-dimensional, steady state incompressible viscous flow problems in the presence of heat transfer. Particular emphasis is placed on the application of the velocity-correction method, ensuring the continuity equation. The Gaussian Radial Basis Functions (GRBF) interpolation is employed to construct the shape functions in conjunction with the framework of the point collocation method. The cases of forced, natural and mixed convection in a 2D rectangular enclosure are examined. The accuracy and the sta- bility of the proposed scheme are demonstrated through three representative, well known and established benchmark problems. Results are presented for high values of the characteristics non-dimensional numbers of the flow, that is, the Reynolds, the Rayleigh and the Richardson number [less ▲]

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See detailMeshfree Point Collocation Schemes for 2D Steady State Incompressible Navier-Stokes Equations in Velocity-Vorticity Formulation for High Values of Reynolds Number
Bourantas, Georgios UL; Skouras, Eugene; Loukopoulos, Vasilios et al

in Computer Modeling in Engineering & Sciences (2010), 59(1), 31-63

A meshfree point collocation method has been developed for the velocity- vorticity formulation of two-dimensional, steady state incompressible Navier-Stokes equations. Particular emphasis was placed on ... [more ▼]

A meshfree point collocation method has been developed for the velocity- vorticity formulation of two-dimensional, steady state incompressible Navier-Stokes equations. Particular emphasis was placed on the application of the velocity-correc- tion method, ensuring the continuity equation. The Moving Least Squares (MLS) approximation is employed for the construction of the shape functions, in conjunc- tion with the general framework of the point collocation method. Computations are obtained for regular and irregular nodal distributions, stressing the positivity con- ditions that make the matrix of the system stable and convergent. The accuracy and the stability of the proposed scheme are demonstrated through two representative, well-known, and established benchmark problems. The numerical scheme was also applied to a case with irregular geometry for marginally high Reynolds numbers [less ▲]

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See detailAdaptive support domain implementation on the Moving Least Squares approximation for Mfree methods applied on elliptic and parabolic PDE problems using strong-form description
Bourantas, Georgios UL; Skouras, Eugene; Nikiforidis, George

in Computer Modeling in Engineering & Sciences (2009), 43

The extent of application of meshfree methods based on point collocation (PC) techniques with adaptive support domain for strong form Partial Differential Equations (PDE) is investigated. The basis ... [more ▼]

The extent of application of meshfree methods based on point collocation (PC) techniques with adaptive support domain for strong form Partial Differential Equations (PDE) is investigated. The basis functions are constructed using the Moving Least Square (MLS) approximation. The weak-form description of PDEs is used in most MLS methods to circumvent problems related to the increased level of resolution necessary near natural (Neumann) boundary conditions (BCs), dislocations, or regions of steep gradients. Alternatively, one can adopt Radial Basis Function (RBF) approximation on the strong-form of PDEs using meshless PC methods, due to the delta function behavior (exact solution on nodes). The present approach is one of the few successful attempts of using MLS approximation [Atluri, Liu, and Han (2006), Han, Liu, Rajendran and Atluri (2006), Atluri and Liu (2006)] instead of RBF approximation for the meshless PC method using strong-form description. To increase the accuracy of the MLS interpolation method and its robustness in problems with natural BCs, a suitable support domain should be chosen in order to ensure an optimized area of coverage for interpolation. To this end, the basis functions are constructed using two different approaches, pertinent to the dimension of the support domain. On one hand, a compact form for the support domain is retained by keeping its radius constant. On the other hand, one can control the number of neighboring nodes as the support domain of each point. The results show that some inaccuracies are present near the boundaries using the first approach, due to the limited number of nodes belonging to the support domain, which results in failed matrix inversion. Instead, the second approach offers capability for fully matrix inversion under many (if not all) circumstances, resulting in basis functions of increased accuracy and robustness. This PC method, applied along with an intelligent adaptive refinement, is demonstrated for elliptic and for parabolic PDEs, related to many flow and mass transfer problems. [less ▲]

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See detailComputational representation and hemodynamic characterization of in vivo acquired severe stenotic renal artery geometries using turbulence modeling
Kagadis, George; Skouras, Eugene; Bourantas, Georgios UL et al

in Medical Engineering & Physics (2008), 30(5), 647-660

The present study reports on computational fluid dynamics in the case of severe renal artery stenosis (RAS). An anatomically realistic model of a renal artery was reconstructed from CT scans, and used to ... [more ▼]

The present study reports on computational fluid dynamics in the case of severe renal artery stenosis (RAS). An anatomically realistic model of a renal artery was reconstructed from CT scans, and used to conduct CFD simulations of blood flow across RAS. The recently developed Shear Stress Transport turbulence model was pivotally applied in the simulation of blood flow in the region of interest. Blood flow was studied in vivo under the presence of RAS and subsequently in simulated cases before the development of RAS, and after endovascular stent implantation. The pressure gradients in the RAS case were many orders of magnitude larger than in the healthy case. The presence of RAS increased flow resistance, which led to considerably lower blood flow rates. A simulated stent in place of the RAS decreased the flow resistance at levels proportional to, and even lower than, the simulated healthy case without the RAS. The wall shear stresses, differential pressure profiles, and net forces exerted on the surface of the atherosclerotic plaque at peak pulse were shown to be of relevant high distinctiveness, so as to be considered potential indicators of hemodynamically significant RAS. [less ▲]

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