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See detailL'éducation thérapeutique: Une solution pour vaincre l'inertie clinique et le défaut d'observance
Scheen, A. J.; Bourguignon, J. P.; Guillaume, M. et al

in Revue Medicale de Liege (2010), 65(5-6), 250-255

Therapeutic education (TPE) aims to enable the patient suffering from a chronic diseases to manage his/her illness and treatment, and prevent avoidable complications, while keeping or improving his/her ... [more ▼]

Therapeutic education (TPE) aims to enable the patient suffering from a chronic diseases to manage his/her illness and treatment, and prevent avoidable complications, while keeping or improving his/her quality of life. it comprises a set de practical tools aiming the patient to acquire skills to manage himself/herself the disease, its care and supervision, in partnership with healthcare providers. TPE may contribute to improve therapeutic compliance and to reduce clinical inertia, two drawbacks frequently encountered in the management of patients with chronic diseases. As an illustration, we briefly present edudora2 («Education thérapeutique et préventive face au diabète et à l'obésité à risque chez l'adulte et l'adolescent» = "Preventive and therapeutic education for diabetes and at risk obesity in adults and adolescents"), an ongoing original project in three frontier regions (Wallonia - Grand-duchy of Luxembourg - Lorraine). [less ▲]

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See detailDifferential binding of IgG and IgA antibodies to antigenic determinants of bovine serum albumin
Hilger, C.; Grigioni, F.; De Beaufort, Carine UL et al

in Clinical and Experimental Immunology (2001), 123(3), 387-394

The aim of this study was to investigate the recognition pattern of bovine serum albumin (BSA), a major dietary protein by serum IgG and IgA antibodies. Anti-BSA IgG and IgA antibodies were measured by ... [more ▼]

The aim of this study was to investigate the recognition pattern of bovine serum albumin (BSA), a major dietary protein by serum IgG and IgA antibodies. Anti-BSA IgG and IgA antibodies were measured by ELISA technique in 3 different cohorts: 578 unselected persons, 84 new-onset insulin-dependent diabetes mellitus (IDDM) patients and 103 atopic persons. In order to characterize the recognition pattern of the different BSA domains, recombinant BSA and recombinant fragments covering the 3 BSA domains were produced. BSA digestion was monitored in simulated gastric fluid experiments by means of domain specific monoclonal antibodies. IgG and IgA antibody titres to native BSA were highest in DDM patients. The three major BSA domains were equally well recognized by IgG antibodies of the three cohorts. Interestingly all three study groups showed a dissociation of their IgG and IgA antibody response to the first BSA domain. The ratio of IgG to IgA antibodies recognizing this domain was 93%/42% in controls, 92%/37% in IDDM patients and 80%/47% in atopic persons. In simulated gastric fluid experiments, the first BSA domain was the first to become undetectable to specific monoclonal antibodies during digestion. In conclusion humoral IgG and IgA antibodies recognize the major BSA domains with different frequencies. The N-terminal domain of BSA, the first to be degraded during simulated gastric digestion is less well recognized by IgA antibodies. This suggests that early digestion is negatively correlated to the IgA antibody response and that the IgA response associated to the gut associated lymphoid tissue (GALT) and the systemic IgG antibody responses are independent. [less ▲]

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See detailEtude de differentes methodes pour la mise en evidence des autoanticorps anti-glutamate-decarboxylase associes au developpement du diabete insulinodependant
Humbel, R. L.; Guillaume, A. C.; Schmit, P. et al

in Immuno-Analyse et Biologie Specialisee (1997), 12(5), 275-279

Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react ... [more ▼]

Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react predominantly with the native GAD. Various methods have been studied (radio immunoassay [RIA] and enzyme- linked immunosorbent assay [ELISA]). It was observed that at the present time only RIA-tests, in which GAD is presented in fluid phase, are able to detect antibodies. [less ▲]

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See detailUtilisation de médicaments anti-diabétiques au Grand Duché de Luxembourg
De Beaufort, Carine UL; Michel, G.; Haas, N. et al

in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (1991), 2

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See detailThe incidence of Type 1 (insulin-dependent) diabetes mellitus in subjects aged 0-19 years in Luxembourg: a retrospective study from 1977 to 1986
De Beaufort, Carine UL; Michel, G.; Glaesener, G.

in Diabetologia (1988), 31(10), 758-761

A decrease in the incidence of Type 1 (insulin-dependent) diabetes mellitus in the age group 0-14 years has been observed from north to south over north-western Europe. To evaluate whether this trend ... [more ▼]

A decrease in the incidence of Type 1 (insulin-dependent) diabetes mellitus in the age group 0-14 years has been observed from north to south over north-western Europe. To evaluate whether this trend could be found in Luxembourg (a small country between the Netherlands and France) we performed a retrospective study over a period of 10 years. Information concerning all Type 1 diabetic patients (aged 0-19 years at diagnosis), diagnosed between January 1, 1977 and December 31, 1986 was obtained through paediatricians, internists, general practitioners and the Luxembourg Diabetes Association (LDA). The LDA was used as the ascertainment group (to estimate the real number and incidence of Type 1 diabetes mellitus). During the study period 91 Type 1 diabetic patients aged between 0-19 years were diagnosed. An incidence of 11.2 was found in boys (0-19 years). Girls in the same age group showed a considerably lower incidence of 8.8. Standardised incidence (using as standard the world population) revealed an almost similar incidence in the Netherlands and Luxembourg (respectively 10.3 and 10.2) for the age group aged 0-14 years. In France a considerably lower incidence is found (3.6). To what extent different methodology contributes to the differences remains to be clarified. Further prospective studies are necessary to investigate the role of environmental and genetic factors. © 1988 Springer-Verlag. [less ▲]

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