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A Polynomial Time Subsumption Algorithm for Nominal Safe $ELO_{\bot}$ under Rational Closure Casini, Giovanni ; ; in Information Sciences (in press) Description Logics (DLs) under Rational Closure (RC) is a well-known framework for non-monotonic reasoning in DLs. In this paper, we address the concept subsumption decision problem under RC for nominal ... [more ▼] Description Logics (DLs) under Rational Closure (RC) is a well-known framework for non-monotonic reasoning in DLs. In this paper, we address the concept subsumption decision problem under RC for nominal safe $ELO_{\bot}$, a notable and practically important DL representative of the OWL 2 profile OWL 2 EL. Our contribution here is to define a polynomial time subsumption procedure for nominal safe $ELO_{\bot}$ under RC that relies entirely on a series of classical, monotonic $EL_{\bot}$ subsumption tests. Therefore, any existing classical monotonic $EL_{\bot}$ reasoner can be used as a black box to implement our method. We then also adapt the method to one of the known extensions of RC for DLs, namely Defeasible Inheritance-based DLs without losing the computational tractability. [less ▲] Detailed reference viewed: 38 (7 UL)A Semantic Perspective on Belief Change in a Preferential Non-Monotonic Framework Casini, Giovanni ; ; et al in Proceedings of the Sixteenth International Conference on Principles of Knowledge Representation and Reasoning (KR 2018) (2018) Belief change and non-monotonic reasoning are usually viewed as two sides of the same coin, with results showing that one can formally be defined in terms of the other. In this paper we investigate the ... [more ▼] Belief change and non-monotonic reasoning are usually viewed as two sides of the same coin, with results showing that one can formally be defined in terms of the other. In this paper we investigate the integration of the two formalisms by studying belief change for a (preferential) non-monotonic framework. We show that the standard AGM approach to be- lief change can be transferred to a preferential non-monotonic framework in the sense that change operations can be defined on conditional knowledge bases. We take as a point of depar- ture the results presented by Casini and Meyer (2017), and we develop and extend such results with characterisations based on semantics and entrenchment relations, showing how some of the constructions defined for propositional logic can be lifted to our preferential non-monotonic framework. [less ▲] Detailed reference viewed: 59 (19 UL)Defeasible Entailment: from Rational Closure to Lexicographic Closure and Beyond Casini, Giovanni ; ; in Proceeding of the 17th International Workshop on Non-Monotonic Reasoning (NMR 2018) (2018) In this paper we present what we believe to be the first systematic approach for extending the framework for de- feasible entailment first presented by Kraus, Lehmann, and Magidor—the so-called KLM ... [more ▼] In this paper we present what we believe to be the first systematic approach for extending the framework for de- feasible entailment first presented by Kraus, Lehmann, and Magidor—the so-called KLM approach. Drawing on the properties for KLM, we first propose a class of basic defea- sible entailment relations. We characterise this basic frame- work in three ways: (i) semantically, (ii) in terms of a class of properties, and (iii) in terms of ranks on statements in a knowlege base. We also provide an algorithm for computing the basic framework. These results are proved through vari- ous representation results. We then refine this framework by defining the class of rational defeasible entailment relations. This refined framework is also characterised in thee ways: se- mantically, in terms of a class of properties, and in terms of ranks on statements. We also provide an algorithm for com- puting the refined framework. Again, these results are proved through various representation results. We argue that the class of rational defeasible entail- ment relations—a strengthening of basic defeasible entail- ment which is itself a strengthening of the original KLM proposal—is worthy of the term rational in the sense that all of them can be viewed as appropriate forms of defeasi- ble entailment. We show that the two well-known forms of defeasible entailment, rational closure and lexicographic clo- sure, fall within our rational defeasible framework. We show that rational closure is the most conservative of the defeasi- ble entailment relations within the framework (with respect to subset inclusion), but that there are forms of defeasible en- tailment within our framework that are more “adventurous” than lexicographic closure. [less ▲] Detailed reference viewed: 46 (8 UL)Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein ; ; et al in Human Molecular Genetics (2018) Detailed reference viewed: 67 (8 UL)On Rational Entailment for Propositional Typicality Logic Casini, Giovanni ; ; et al Report (2018) Propositional Typicality Logic (PTL) is a recently proposed logic, obtained by enriching classical propositional logic with a typicality operator capturing the most typical (alias normal or conventional ... [more ▼] Propositional Typicality Logic (PTL) is a recently proposed logic, obtained by enriching classical propositional logic with a typicality operator capturing the most typical (alias normal or conventional) situations in which a given sentence holds. The semantics of PTL is in terms of ranked models as studied in the well-known KLM approach to preferential reasoning and therefore KLM-style rational consequence relations can be embedded in PTL. In spite of the non-monotonic features introduced by the semantics adopted for the typicality operator, the obvious Tarskian definition of entailment for PTL remains monotonic and is therefore not appropriate in many contexts. Our first important result is an impossibility theorem showing that a set of proposed postulates that at first all seem appropriate for a notion of entailment with regard to typicality cannot be satisfied simultaneously. Closer inspection reveals that this result is best interpreted as an argument for advocating the development of more than one type of PTL entailment. In the spirit of this interpretation, we investigate three different (semantic) versions of entailment for PTL, each one based on the definition of rational closure as introduced by Lehmann and Magidor for KLM-style conditionals, and constructed using different notions of minimality. [less ▲] Detailed reference viewed: 30 (0 UL)Belief Change in a Preferential Non-Monotonic Framework Casini, Giovanni ; in Proceedings of the Twenty-Sixth International Joint Conference on Artificial Intelligence (2017, August) Belief change and non-monotonic reasoning are usually viewed as two sides of the same coin, with results showing that one can formally be defined in terms of the other. In this paper we show that we can ... [more ▼] Belief change and non-monotonic reasoning are usually viewed as two sides of the same coin, with results showing that one can formally be defined in terms of the other. In this paper we show that we can also integrate the two formalisms by studying belief change within a (preferential) non-monotonic framework. This integration relies heavily on the identification of the monotonic core of a non-monotonic framework. We consider belief change operators in a non-monotonic propositional setting with a view towards preserving consistency. These results can also be applied to the preservation of coherence—an important notion within the field of logic-based ontologies. We show that the standard AGM approach to belief change can be adapted to a preferential non-monotonic framework, with the definition of expansion, contraction, and revision operators, and corresponding representation results. Surprisingly, preferential AGM belief change, as defined here, can be obtained in terms of classical AGM belief change. [less ▲] Detailed reference viewed: 143 (4 UL)Extending Typicality for Description Logics ; Casini, Giovanni ; et al Report (2017) Recent extensions of description logics for dealing with different forms of non-monotonic reasoning don’t take us beyond the case of defeasible subsumption. In this paper we enrich the DL EL⊥ with a ... [more ▼] Recent extensions of description logics for dealing with different forms of non-monotonic reasoning don’t take us beyond the case of defeasible subsumption. In this paper we enrich the DL EL⊥ with a (constrained version of) a typicality operator •, the intuition of which is to capture the most typical members of a class, providing us with the DL EL•⊥. We argue that EL•⊥ is the smallest step one can take to increase the expressivity beyond the case of defeasible subsumption for DLs, while still retaining all the rationality properties an appropriate notion of defeasible subsumption is required to satisfy, and investigate what an appropriate notion of non-monotonic entailment for EL•⊥ should look like. [less ▲] Detailed reference viewed: 60 (4 UL)Revising Incompletely Specified Convex Probabilistic Belief Bases ; ; Casini, Giovanni in Kern-Isberner,, Gabriele; Wassermann, Renata (Eds.) Proceedings of the 16th International Workshop on Non-Monotonic Reasoning (NMR 2016) (2016, April) We propose a method for an agent to revise its incomplete probabilistic beliefs when a new piece of propositional information is observed. In this work, an agent’s beliefs are represented by a set of ... [more ▼] We propose a method for an agent to revise its incomplete probabilistic beliefs when a new piece of propositional information is observed. In this work, an agent’s beliefs are represented by a set of probabilistic formulae – a belief base. The method involves determining a representative set of ‘boundary’ probability distributions consistent with the current belief base, revising each of these probability distributions and then translating the revised information into a new belief base. We use a version of Lewis Imaging as the revision operation. The correctness of the approach is proved. The expressivity of the belief bases under consideration are rather restricted, but has some applications. We also discuss methods of belief base revision employing the notion of optimum entropy, and point out some of the benefits and difficulties in those methods. Both the boundary distribution method and the optimum entropy method are reasonable, yet yield different results. [less ▲] Detailed reference viewed: 27 (3 UL)Using Defeasible Information to Obtain Coherence Casini, Giovanni ; in Baral, Chitta; Delgrande, James; Wolter, Frank (Eds.) Proceedings of the 15th International Conference on Principle of Knowledge Representation and Reasoning (KR-16) (2016, April) We consider the problem of obtaining coherence in a propositional knowledge base using techniques from Belief Change. Our motivation comes from the field of formal ontologies where coherence is ... [more ▼] We consider the problem of obtaining coherence in a propositional knowledge base using techniques from Belief Change. Our motivation comes from the field of formal ontologies where coherence is interpreted to mean that a concept name has to be satisfiable. In the propositional case we consider here, this translates to a propositional formula being satisfiable. We define belief change operators in a framework of nonmonotonic preferential reasoning.We show how the introduction of defeasible information using contraction operators can be an effective means for obtaining coherence. [less ▲] Detailed reference viewed: 42 (16 UL)Using Defeasible Information to Obtain Coherence Casini, Giovanni ; in BNAIC 2016 - Proceedings of the 28th Benelux Conference on Artificial intelligence (2016) In this paper we consider the problem of obtaining coherence in a propositional knowledge base using techniques from Belief Change. Our motivation comes from the field of formal ontologies where coherence ... [more ▼] In this paper we consider the problem of obtaining coherence in a propositional knowledge base using techniques from Belief Change. Our motivation comes from the field of formal ontologies where coherence is interpreted to mean that a concept name has to be satisfiable. [less ▲] Detailed reference viewed: 23 (4 UL)On Revision of Partially Specified Convex Probabilistic Belief Bases ; ; Casini, Giovanni in Proceedings of the 22nd European Conference on Artificial Intelligence (ECAI-16) (2016) We propose a method for an agent to revise its incomplete probabilistic beliefs when a new piece of propositional information is observed. In this work, an agent’s beliefs are represented by a set of ... [more ▼] We propose a method for an agent to revise its incomplete probabilistic beliefs when a new piece of propositional information is observed. In this work, an agent’s beliefs are represented by a set of probabilistic formulae – a belief base. The method involves determining a representative set of ‘boundary’ probability distributions consistent with the current belief base, revising each of these probability distributions and then translating the revised information into a new belief base. We use a version of Lewis Imaging as the revision operation. The correctness of the approach is proved. An analysis of the approach is done against six rationality postulates. The expressivity of the belief bases under consideration are rather restricted, but has some applications. We also discuss methods of belief base revision employing the notion of optimum entropy, and point out some of the benefits and difficulties in those methods. Both the boundary distribution method and the optimum entropy methods are reasonable, yet yield different results. [less ▲] Detailed reference viewed: 75 (5 UL)Introducing Defeasibility into OWL Ontologies Casini, Giovanni ; ; et al in Arenas, Marcelo; Corcho, Oscar; Simperl, Elena (Eds.) et al 14th International Semantic Web Conference. Bethlehem, PA, USA, October 11–15, 2015 Proceedings, Part II (2015) In recent years, various approaches have been developed for representing and reasoning with exceptions in OWL. The price one pays for such capabilities, in terms of practical performance, is an important ... [more ▼] In recent years, various approaches have been developed for representing and reasoning with exceptions in OWL. The price one pays for such capabilities, in terms of practical performance, is an important factor that is yet to be quantified comprehensively. A major barrier is the lack of naturally occurring ontologies with defeasible features - the ideal candidates for evaluation. Such data is unavailable due to absence of tool support for representing defeasible features. In the past, defeasible reasoning implementations have favoured automated generation of defeasible ontologies. While this suffices as a preliminary approach, we posit that a method somewhere in between these two would yield more meaningful results. In this work, we describe a systematic approach to modify real-world OWL ontologies to include defeasible features, and we apply this to the Manchester OWL Repository to generate defeasible ontologies for evaluating our reasoner DIP (Defeasible-Inference Platform). The results of this evaluation are provided together with some insights into where the performance bottle-necks lie for this kind of reasoning. We found that reasoning was feasible on the whole, with surprisingly few bottle-necks in our evaluation. [less ▲] Detailed reference viewed: 36 (3 UL)On the Entailment Problem for a Logic of Typicality Booth, Richard ; Casini, Giovanni ; et al in Yang, Qiang; Wooldridge, Michael (Eds.) Proceedings of the TwentyFourth International Joint Conference on Artificial Intelligence. Buenos Aires, Argentina, 25–31 July 2015 (2015) Propositional Typicality Logic (PTL) is a recently proposed logic, obtained by enriching classical propositional logic with a typicality operator. In spite of the non-monotonic features introduced by the ... [more ▼] Propositional Typicality Logic (PTL) is a recently proposed logic, obtained by enriching classical propositional logic with a typicality operator. In spite of the non-monotonic features introduced by the semantics adopted for the typicality operator, the obvious Tarskian definition of entailment for PTL remains monotonic and is therefore not appropriate. We investigate different (semantic) versions of entailment for PTL, based on the notion of Rational Closure as defined by Lehmann and Magidor for KLM-style conditionals, and constructed using minimality. Our first important result is an impossibility theorem showing that a set of proposed postulates that at first all seem appropriate for a notion of entailment with regard to typicality cannot be satisfied simultaneously. Closer inspection reveals that this result is best interpreted as an argument for advocating the development of more than one type of PTL entailment. In the spirit of this interpretation, we define two primary forms of entailment for PTL and discuss their advantages and disadvantages. [less ▲] Detailed reference viewed: 40 (3 UL)A non-classical logical foundation for naturalised realism ; Casini, Giovanni ; in Arazim, Pavel; Dančák, michal (Eds.) The Logica Yearbook (2015) Detailed reference viewed: 67 (4 UL)A propositional typicality logic for extending rational consequence Booth, Richard ; ; in Trends in Belief Revision and Argumentation Dynamics (2013) Detailed reference viewed: 8 (0 UL)Einleitung und Überblick ; ; Samuel, Robin et al in Bildung – Arbeit – Erwachsenwerden (2012) Detailed reference viewed: 29 (0 UL)Bildung – Arbeit – Erwachsenwerden ; ; et al Book published by Springer VS (2012) Der Übergang von der Schule ins Erwachsenen- und Erwerbsleben ist eine entscheidende und kritische Lebensphase. Vieles deutet darauf hin, dass diese Transition in modernen Gesellschaften länger ... [more ▼] Der Übergang von der Schule ins Erwachsenen- und Erwerbsleben ist eine entscheidende und kritische Lebensphase. Vieles deutet darauf hin, dass diese Transition in modernen Gesellschaften länger, anforderungsreicher, ... [less ▲] Detailed reference viewed: 58 (10 UL)A general family of preferential belief removal operators Booth, Richard ; ; in Journal of Philosophical Logic (2012), 41(4), 711-733 Most belief change operators in the AGM tradition assume an underlying plausibility ordering over the possible worlds which is transitive and complete. A unifying structure for these operators, based on ... [more ▼] Most belief change operators in the AGM tradition assume an underlying plausibility ordering over the possible worlds which is transitive and complete. A unifying structure for these operators, based on supplementing the plausibility ordering with a second, guiding, relation over the worlds was presented in Booth et al. (Artif Intell 174:1339–1368, 2010). However it is not always reasonable to assume completeness of the underlying ordering. In this paper we generalise the structure of Booth et al. (Artif Intell 174:1339–1368, 2010) to allow incomparabilities between worlds. We axiomatise the resulting class of belief removal functions, and show that it includes an important family of removal functions based on finite prioritised belief bases. [less ▲] Detailed reference viewed: 42 (0 UL)PTL: A propositional typicality logic Booth, Richard ; ; in 13th Conference on Logics in Artificial Intelligence (JELIA 2012) (2012) Detailed reference viewed: 26 (1 UL)Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. ; ; Noor, Fozia et al in Journal of applied toxicology : JAT (2011), 31(3), 191-205 In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art ... [more ▼] In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art bioanalytical methods and sensors is reviewed. The focus is on hESC-derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring critical cardiotoxicity parameters are highlighted, together with aspects of data evaluation and validation. Finally, recommendations for further research are given. [less ▲] Detailed reference viewed: 20 (0 UL) |
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