References of "Ebnet, Klaus"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailJAM-C is an apical surface marker for neural stem cells.
Stelzer, Sandra; Worlitzer, Maik M. A.; Bahnassawy, Lamia A et al

in Stem Cells & Development (2012), 21(5), 757-66

Junctional adhesion molecule-C (JAM-C) is an adhesive cell surface protein expressed in various cell types. JAM-C localizes to the apically localized tight junctions (TJs) between contacting endothelial ... [more ▼]

Junctional adhesion molecule-C (JAM-C) is an adhesive cell surface protein expressed in various cell types. JAM-C localizes to the apically localized tight junctions (TJs) between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesions. Just as those epithelial cells, also neural stem cells are highly polarized along their apical-basal axis. The defining feature of all stem cells, including neural stem cells (NSCs) is their ability to self renew. This self-renewal depends on the tight control of symmetric and asymmetric cell divisions. In NSCs, the decision whether a division is symmetric or asymmetric largely depends on the distribution of the apical membrane and cell fate determinants on the basal pole of the cell. In this study we demonstrate that JAM-C is expressed on neural progenitor cells and neural stem cells in the embryonic as well as the adult mouse brain. Furthermore, we demonstrate that in vivo JAM-C shows enrichment at the apical surface and therefore is asymmetrically distributed during cell divisions. These results define JAM-C as a novel surface marker for neural stem cells. [less ▲]

Detailed reference viewed: 100 (2 UL)
Full Text
Peer Reviewed
See detailJAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
Stelzer, Sandra; Ebnet, Klaus; Schwamborn, Jens Christian UL

in BMC Neuroscience (2010), 11

BACKGROUND: Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where ... [more ▼]

BACKGROUND: Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. RESULTS: So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. CONCLUSIONS: Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. [less ▲]

Detailed reference viewed: 105 (0 UL)