References of "Caberlotto, Laura"
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See detailCrowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Allen, Genevera; Amoroso, Nicola; Anghel, Catalina et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2016), 12(6), 645-653

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See detailSystems biology integration of proteomic data in rodent models of depression reveals involvement of the immune response and glutamatergic signalling
Carboni, Lucia; Nguyen, Thanh Phuong UL; Caberlotto, Laura

in PROTEOMICS – Clinical Applications (2016)

Purpose The pathophysiological basis of major depression is incompletely understood. Recently, numerous proteomic studies have been performed in rodent models of depression to investigate the molecular ... [more ▼]

Purpose The pathophysiological basis of major depression is incompletely understood. Recently, numerous proteomic studies have been performed in rodent models of depression to investigate the molecular underpinnings of depressive-like behaviours with an unbiased approach. The objective of the study was to integrate the results of these proteomic studies in depression models to shed light on the most relevant molecular pathways involved in the disease. Experimental design Network analysis was performed integrating pre-existing proteomic data from rodent models of depression. The IntAct mouse and the HRPD were used as reference protein-protein interaction databases. The functionality analyses of the networks were then performed by testing over-represented GO biological process terms and pathways. Results Functional enrichment analyses of the networks revealed an association with molecular processes related to depression in humans, such as those involved in the immune response. Pathways impacted by clinically effective antidepressants were modulated, including glutamatergic signalling and neurotrophic responses. Moreover, dysregulations of proteins regulating energy metabolism and circadian rhythms were implicated. The comparison with protein pathways modulated in depressive patients revealed significant overlapping. Conclusions and clinical relevance This systems biology study supports the notion that animal models could contribute to the research into the biology and therapeutics of depression. [less ▲]

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See detailNovel drug target identification for the treatment of dementia using multi-relational association mining
Nguyen, Thanh Phuong UL; Priami, Corrado; Caberlotto, Laura

in Scientific Reports (2015), 5

Dementia is a neurodegenerative condition of the brain in which there is a progressive and permanent loss of cognitive and mental performance. Despite the fact that the number of people with dementia ... [more ▼]

Dementia is a neurodegenerative condition of the brain in which there is a progressive and permanent loss of cognitive and mental performance. Despite the fact that the number of people with dementia worldwide is steadily increasing and regardless of the advances in the molecular characterization of the disease, current medical treatments for dementia are purely symptomatic and hardly effective. We present a novel multi-relational association mining method that integrates the huge amount of scientific data accumulated in recent years to predict potential novel targets for innovative therapeutic treatment of dementia. Owing to the ability of processing large volumes of heterogeneous data, our method achieves a high performance and predicts numerous drug targets including several serine threonine kinase and a G-protein coupled receptor. The predicted drug targets are mainly functionally related to metabolism, cell surface receptor signaling pathways, immune response, apoptosis, and long-term memory. Among the highly represented kinase family and among the G-protein coupled receptors, DLG4 (PSD-95), and the bradikynin receptor 2 are highlighted also for their proposed role in memory and cognition, as described in previous studies. These novel putative targets hold promises for the development of novel therapeutic approaches for the treatment of dementia. [less ▲]

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See detailInference of Autism-Related Genes by Integrating Protein-Protein Interactions and miRNA-Target Interactions
Tran, Dang Hung; Nguyen, Thanh Phuong UL; Caberlotto, Laura et al

in Knowledge and Systems Engineering (2014)

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See detailNetwork analysis of neurodegenerative disease highlights a role of toll-like receptor signaling
Nguyen, Thanh Phuong UL; Caberlotto, Laura; Morine, Melissa J. et al

in BioMed Research International (2014), 2014

Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions ... [more ▼]

Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions between diseases are not always entirely clear. We present an efficient computationalmethod based on protein-protein interaction network (PPI) tomodel the functional network of NDs. The aim of this work is fourfold: (i) reconstruction of a PPI network relating to the NDs, (ii) construction of an association network between diseases based on proximity in the disease PPI network, (iii) quantification of disease associations, and (iv) inference of potentialmolecularmechanisminvolved in the diseases.The functional links of diseases not only showed overlap with the traditional classification in clinical settings, but also offered new insight into connections between diseases with limited clinical overlap. To gain an expanded view of the molecular mechanisms involved in NDs, both direct and indirect connector proteins were investigated. The method uncovered molecular relationships that are in common apparently distinct diseases and provided important insight into the molecular networks implicated in disease pathogenesis. In particular, the current analysis highlighted the Toll-like receptor signaling pathway as a potential candidate pathway to be targeted by therapy in neurodegeneration. [less ▲]

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See detailA systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy
Caberlotto, Laura; Nguyen, Thanh Phuong UL

in BMC Systems Biology (2014), 8(1), 65

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See detailThe central role of AMP-kinase and energy homeostasis impairment in Alzheimer’s disease: a multifactor network analysis
Caberlotto, Laura; Lauria, Mario; Nguyen, Thanh Phuong UL et al

in PLoS ONE (2013)

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